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排序方式: 共有43条查询结果,搜索用时 15 毫秒
1.
Friederike A. Sandbaumhüter Claudia Gittel M. Paula Larenza-Menzies Regula Theurillat Wolfgang Thormann Christina Braun 《Electrophoresis》2021,42(17-18):1826-1831
The enantioselectivity of the pharmacokinetics of methadone was investigated in anesthetized Shetland ponies after a single intravenous (0.5 mg/kg methadone hydrochloride; n = 6) or constant rate infusion (0.25 mg/kg bolus followed by 0.25 mg/kg/h methadone hydrochloride; n = 3) administration of racemic methadone. Plasma concentrations of l -methadone and d -methadone and their major metabolites, l - and d -2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), respectively, were analyzed by CE with highly sulfated γ-cyclodextrin as chiral selector and electrokinetic analyte injection from liquid/liquid extracts prepared at alkaline pH. In both trials, the d -methadone concentrations were lower than those of l -methadone and the d -EDDP levels were lower than those of L-EDDP. For the case of a single intravenous bolus injection, the plasma concentration versus time profile of methadone enantiomers was analyzed with a two-compartment pharmacokinetic model. l -methadone showed a slower elimination rate constant, a lower body clearance, and a smaller steady-state volume of distribution than d -methadone. d -methadone and d -EDDP were eliminated faster than their respective l -enantiomers. This is the first study that outlines that the disposition of racemic methadone administered to anesthetized equines is enantioselective. 相似文献
2.
Therapeutic drug monitoring of cefepime with micellar electrokinetic capillary chromatography: Assay improvement,quality assurance,and impact on patient drug levels 下载免费PDF全文
Regula Theurillat Jeannine Joneli Ursula Wanzenried Jeannette Schiess Monika Hurni Thomas Weber Parham Sendi Wolfgang Thormann 《Journal of separation science》2016,39(13):2626-2632
The improvement and performance of a micellar electrokinetic capillary chromatography assay for cefepime in human serum and plasma with a 50 μm id fused‐silica capillary elongated from 40 to 60 cm is reported. Sample preparation with dodecylsulfate protein precipitation at pH 4.5, the pH 9.1 separation medium, and the applied voltage were as reported previously [16]. The change resulted in a significant lower current, higher resolution, and increased detection time intervals. The performance of the assay with multilevel internal calibration was assessed with calibration and control samples. Quality assurance data of a 2‐year period assessed under the new conditions demonstrated the robustness of the assay. In serum samples of patients who received both cefepime and sulfamethoxazole, cefepime could not be detected due to the inseparability of the two compounds. The presence of an interference can be recognized by an increased peak width (width > 0.2 min), the appearance of a shoulder or an unresolved double peak. The patient data gathered during a 3‐year period reveal that introduction of therapeutic drug monitoring led to a 50% reduction of the median drug level. The data suggest that therapeutic drug monitoring can help to minimize the risk of major adverse reactions and to increase drug safety on an individual basis. 相似文献
3.
Walter Renold Regula Nf-Müller Urs Keller Bruno Willhalm Günther Ohloff 《Helvetica chimica acta》1974,57(5):1301-1308
A total of 68 constitutents, mainly aldehydes, ketones and esters, have been identified for the first time in a black tea aroma concentrate using coupled gas-chromatography/mass spectrometry. 相似文献
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In 2,6-di-unsaturated carbonyl compounds, two successive, site-specific hydrogen transfers are necessary to account for the loss of carbon atoms 1, 2, 3 and 4, together with one hydrogen from C-8. The deuterated methyl geranate required for this study was readily converted to pseudo-ionone, in which a similar fission was shown to occur. Previous predictions about the β-ionone mass spectrum2 have been shown to be substantially correct, and its similarity to the mass spectra of benzylidence acetones is pointed out. 相似文献
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While several studies on the public opinion of nanotechnology have pointed to a rather enthusiastic U.S. public, the public
uptake of nanotechnology in Europe is more contained. The results of the Swiss publifocus on nanotechnology reveal a pragmatic attitude of citizens toward the emerging technologies, thus confirming what has been
identified as a “balanced approach” in the NanoJury UK.
相似文献
Regula Valérie BurriEmail: |
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Baldacci A Theurillat R Caslavska J Pardubská H Brenneisen R Thormann W 《Journal of chromatography. A》2003,990(1-2):99-110
γ-Hydroxybutyric acid (GHB), a minor metabolite or precursor of γ-aminobutyric acid (GABA), acts as a neurotransmitter/neuromodulator via binding to GABA receptors and to specific presynaptic GHB receptors. Based upon the stimulatory effects, GHB is widely abused. Thus, there is great interest in monitoring GHB in body fluids and tissues. We have developed an assay for urinary GHB that is based upon liquid–liquid extraction and capillary zone electrophoresis (CZE) with indirect UV absorption detection. The background electrolyte is composed of 4 mM nicotinic acid (compound for indirect detection), 3 mM spermine (reversal of electroosmosis) and histidine (added to reach a pH of 6.2). Having a 50 μm I.D. capillary of 40 cm effective length, 1-octanesulfonic acid as internal standard, solute detection at 214 nm and a diluted urine with a conductivity of 2.4 mS/cm, GHB concentrations ≥2 μg/ml can be detected. Limit of detection (LOD) and limit of quantitation (LOQ) were determined to be dependent on urine concentration and varied between 2–24 and 5–60 μg/ml, respectively. Data obtained suggest that LOD and LOQ (both in μg/ml) can be estimated with the relationships 0.83 κ and 2.1 κ, respectively, where κ is the conductivity of the urine in mS/cm. The assay was successfully applied to urines collected after administration of 25 mg sodium GHB/kg body mass. Negative electrospray ionization ion-trap tandem mass spectrometry was used to confirm the presence of GHB in the urinary extract via selected reaction monitoring of the m/z 103.1→m/z 85.1 precursor–product ion transition. Independent of urine concentration, this approach meets the urinary cut-off level of 10 μg/ml that is required for recognition of the presence of exogenous GHB. Furthermore, data obtained with injection of plain or diluted urine indicate that CZE could be used to rapidly recognize GHB amounts (in μg/ml) that are ≥ 4 κ. 相似文献
10.
From bergamot oil (Citrus bergamia RISSO), (?)-(4S, 8R)-8-epi-α-bisabolol ( 2 ) and (?)-(4R, 8S)-4-epi-β-bisabolol ( 3 ) were isolated. The absolute configuration of their stereoisomers 4 and 5 was established by an enantioselective synthesis starting from (?)-(S)-p-mentha-1,8-dien-4-ol. 相似文献