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CH Oxidation of Ingenanes Enables Potent and Selective Protein Kinase C Isoform Activation 下载免费PDF全文
Dr. Yehua Jin Dr. Chien‐Hung Yeh Dr. Christian A. Kuttruff Dr. Lars Jørgensen Dr. Georg Dünstl Dr. Jakob Felding Dr. Swaminathan R. Natarajan Prof. Dr. Phil S. Baran 《Angewandte Chemie (International ed. in English)》2015,54(47):14044-14048
Ingenol derivatives with varying degrees of oxidation were prepared by two‐phase terpene synthesis. This strategy has allowed access to analogues that cannot be prepared by semisynthesis from natural ingenol. Complex ingenanes resulting from divergent C? H oxidation of a common intermediate were found to interact with protein kinase C in a manner that correlates well with the oxidation state of the ingenane core. Even though previous work on ingenanes has suggested a strong correlation between potential to activate PKCδ and induction of neutrophil oxidative burst, the current study shows that the potential to activate PKCβII is of key importance while interaction with PKCδ is dispensable. Thus, key modifications of the ingenane core allowed PKC isoform selectivity wherein PKCδ‐driven activation of keratinocytes is strongly reduced or even absent while PKCβII‐driven activation of neutrophils is retained. 相似文献
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建立了微波等离子体原子发射光谱法(MP-AES)测定地质样品中的常量和微量元素的方法,四酸(盐酸+硝酸+高氯酸+氢佛酸)消解样品,得出了使用4200 MP-AES仪分析地化认证参考物质中常规金属元素(Ag,Cu,Ni,Pb和Zn)的结果,测定样品结果的相对标准偏差落在±10%范围内,另外,IEC和FLIC模型可成功校正光谱干扰。MP-AES仪无需使用乙炔等危险气体,极大提高了实验室安全性并显著降低了运行成本。MP-AES仪已成功应用于地化样品的分析中,结果准确可靠。 相似文献
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Dr. Tian Qin Dr. Lara R. Malins Jacob T. Edwards Rohan R. Merchant Alexander J. E. Novak Jacob Z. Zhong Riley B. Mills Ming Yan Dr. Changxia Yuan Dr. Martin D. Eastgate Prof. Phil S. Baran 《Angewandte Chemie (International ed. in English)》2017,56(1):260-265
Two named reactions of fundamental importance and paramount utility in organic synthesis have been reinvestigated, the Barton decarboxylation and Giese radical conjugate addition. N ‐hydroxyphthalimide (NHPI) based redox‐active esters were found to be convenient starting materials for simple, thermal, Ni‐catalyzed radical formation and subsequent trapping with either a hydrogen atom source (PhSiH3) or an electron‐deficient olefin. These reactions feature operational simplicity, inexpensive reagents, and enhanced scope as evidenced by examples in the realm of peptide chemistry. 相似文献
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We review the process of star formation, detailing the theories underlying the stability of molecular clouds and their collapse to protostars, and discussing the empirical evidence and models which inform them. We give emphasis to the role that the magnetic field plays in influencing the stability of molecular clouds and hence the star formation rate. The end result of star formation is a mass function which appears constant within our Galaxy. A relative abundance of low mass stars is observed over high mass stars and most of the stars that do form are found to exist as members of a binary system. The origin of binarity is reviewed as is the discovery, formation and observations of some of the lowest mass stars known, the brown dwarfs. 相似文献
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Triphenylphosphine/carbon tetrachloride and triphenyl-phosphine/N-bromosuccinimide were found to be very effective for β-lactam formation from β-amino acids in acetonitrile. 相似文献
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