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排序方式: 共有212条查询结果,搜索用时 31 毫秒
1.
7‐(2‐Oxoalkoxy)coumarins: Synthesis and Anti‐Inflammatory Activity of a Series of Substituted Coumarins 下载免费PDF全文
Juri Timonen Katriina Vuolteenaho Tiina Leppänen Riina Nieminen Eeva Moilanen Paula Aulaskari Janne Jänis 《Journal of heterocyclic chemistry》2015,52(5):1286-1295
A series of 7‐(2‐oxoalkoxy)coumarins have been synthesized by conjugating substituted 7‐hydroxycoumarins with different chloroketones. The anti‐inflammatory properties of 7‐(2‐oxoalkoxy)coumarins were studied in LPS‐induced inflammatory response in J774 macrophages. Western blot was used to determine the expression of iNOS and COX‐2, NO was determined by measuring its metabolite nitrite by Griess reaction and IL‐6 was measured by ELISA. Seventeen of the studied compounds inhibited NO and IL‐6 production over 50% at 100 μM concentrations. IC50 values of the best inhibitors were 21 μM/24 μM (NO/IL‐6) for compound 12 and 30 μM/10 μM (NO/IL‐6) for compound 20 . The main result was that the substitution with 7‐(2‐oxoalkoxy) group improved the anti‐inflammatory properties of most of the investigated 7‐hydroxycoumarins. 相似文献
2.
Annihilation characteristics are calculated for positrons trapped in clean and impurity decorated vacancy clusters in Au. The positron lifetime depends strongly on the structure of the clusters. In a strongly relaxed vacancy cluster, the lifetime can become smaller than the lifetime in a single vacancy. The substitution of some neighbour atoms of a vacancy cluster by Fe atoms has only a minor effect on the positron lifetimes. 相似文献
3.
Myriam E. Rodriguez Ping Zhang Kashif Azizuddin Grace B. Delos Santos Song-mao Chiu Liang-yan Xue Jeffery C. Berlin Xinzhan Peng Hongqiao Wu Minh Lam Anna-Liisa Nieminen Malcolm E. Kenney Nancy L. Oleinick 《Photochemistry and photobiology》2009,85(5):1189-1200
The phthalocyanine photosensitizer Pc 4 has been shown to bind preferentially to mitochondrial and endoplasmic reticulum membranes. Upon photoirradiation of Pc 4-loaded cells, membrane components, especially Bcl-2, are photodamaged and apoptosis, as indicated by activation of caspase-3 and cleavage of poly(ADP-ribose) polymerase, is triggered. A series of analogs of Pc 4 were synthesized, and the results demonstrate that Pcs with the aminopropylsiloxy ligand of Pc 4 or a similar one on one side of the Pc ring and a second large axial ligand on the other side of the ring have unexpected properties, including enhanced cell uptake, greater monomerization resulting in greater intracellular fluorescence and three-fold higher affinity constants for liposomes. The hydroxyl-bearing axial ligands tend to reduce aggregation of the Pc and direct it to lysosomes, resulting in four to six times more killing of cells, as defined by loss of clonogenicity, than with Pc 4. Whereas Pc 4-PDT photodamages Bcl-2 and Bcl-xL, Pc 181-PDT causes much less photodamage to Bcl-2 over the same dose–response range relative to cell killing, with earlier cleavage of Bid and slower caspase-3-dependent apoptosis. Therefore, within this series of photosensitizers, these hydroxyl-bearing axial ligands are less aggregated than is Pc 4, tend to localize to lysosomes and are more effective in overall cell killing than is Pc 4, but induce apoptosis more slowly and by a modified pathway. 相似文献
4.
Katarina Dimic-Misic Antti Puisto Patrick Gane Kaarlo Nieminen Mikko Alava Jouni Paltakari Thaddeus Maloney 《Cellulose (London, England)》2013,20(6):2847-2861
The influence of swelling on the rheological and dewatering properties of high consistency nanocellulose based furnishes is considered. Different consistencies of suspensions (1–4 %) and furnishes (5–15 %) were prepared made of two distinctly different grades of nanocellulose containing, micro fibrillated (MFC) and nanofibrillated (NFC) cellulose, and systematic comparison between the rheological and dewatering parameters was conducted. The characterization of the rheological and dewatering properties was performed with a stress controlled rheometer combined with an immobilization cell in parallel plate geometry, as well as with an independent gravimetric dewatering device. The surface charge of nanofibrillated cellulose was found to influence the rheological and dewatering properties of the evaluated suspensions and furnishes due to its impact on swelling and effectively bound water. Due to the complex behavior of the novel materials, the immobilization times were difficult to determine from the changes in the damping factor, as often used for coating colors. Instead, we propose a modified method for determination of immobilization times based on a rheological analysis adopting the rate of change in viscoelastic loss factor over time, d(tan δ = G′′/G′)/dt, describing the critical point(s) in the ratio of the viscous to elastic stress response moduli. With this approach we show that it is possible to characterize immobilization of these materials incorporating the concept of the combined physical interactions of the components and the non-removable bound water, without requiring a direct measure of the nanocellulose surface swelling. Based on the results, we hypothesize that fibrillar swelling impacts the dewatering of MFC and NFC suspensions, and furnishes containing them, by an interfiber pore connectivity blocking/sealing mechanism, which effectively defines the immobilization of the material matrix at the end point of free water extraction caused by the physical blocking imposed by the remaining bound water. 相似文献
5.
Panu T. Vesanen Jaakko O. Nieminen Koos C.J. Zevenhoven Yi-Cheng Hsu Risto J. Ilmoniemi 《Magnetic resonance imaging》2014
Electric current density can be measured noninvasively with magnetic resonance imaging (MRI). Determining all three components of the current density, however, requires physical rotation of the sample or current injection from several directions when done with conventional methods. However, the emerging technology of ultra-low-field (ULF) MRI, in which the signal encoding and acquisition is conducted at a microtesla-range magnetic field, offers new possibilities. The low applied magnetic fields can even be switched off completely within the pulse sequence, increasing the flexibility of the available sequences. In this article, we present a ULF-MRI sequence designed for obtaining all three components of a current-density pattern without the need of sample rotations. The sequence consists of three steps: prepolarization of the sample, signal encoding in the current-density-associated magnetic field without applying any MRI fields, and spatial encoding in a microtesla-range field using any standard ULF-MRI sequence. The performance of the method is evaluated by numerical simulations. The method may find applications, e.g., in noninvasive conductivity imaging of tissue. 相似文献
6.
Two strong simultaneous resonances of scattering – double-resonant extremely asymmetrical scattering (DEAS) – are predicted in two parallel, oblique, periodic Bragg arrays separated by a gap, when the scattered wave propagates parallel to the arrays. One of these resonances is with respect to frequency (which is common to all types of Bragg scattering), and another is with respect to phase variation between the arrays. The diffractional divergence of the scattered wave is shown to be the main physical reason for DEAS in the considered structure. Although the arrays are separated, they are shown to interact by means of the diffractional divergence of the scattered wave across the gap from one array into the other. It is also shown that increasing separation between the two arrays results in a broader and weaker resonance with respect to phase shift. The analysis is based on a recently developed new approach allowing for the diffractional divergence of the scattered wave inside and outside the arrays. Physical interpretations of the predicted features of DEAS in separated arrays are also presented. Applicability conditions for the developed theory are derived. 相似文献
7.
M. Marlo-Helle A. Harju R.M. Nieminen 《Physica E: Low-dimensional Systems and Nanostructures》2005,26(1-4):286
We study ground states and far-infrared spectra (FIR) of two electrons in four-minima quantum-dot molecule in magnetic field by exact diagonalization. Ground states consist of altering singlet and triplet states, whose frequency, as a function of magnetic field, increases with increasing dot–dot separation. When the Zeeman energy is included, only the two first singlet states remain as ground states. In the FIR spectra, we observe discontinuities due to crossing ground states. Non-circular symmetry induces anticrossings, and also an additional mode above ω+ in the spin-triplet spectrum. In particular, we conclude that electron–electron interactions cause only minor changes to the FIR spectra and deviations from the Kohn modes result from the low-symmetry confinement potential. 相似文献
8.
A. Kankainen G. K. Vorobjev S. A. Eliseev W. Huang J. Huikari A. Jokinen A. Nieminen Yu. N. Novikov H. Penttilä A. V. Popov S. Rinta-Antila H. Schatz D. M. Seliverstov Yu. P. Suslov J. Äystö 《The European Physical Journal A - Hadrons and Nuclei》2005,25(3):355-363
Decay properties of neutron-deficient exotic nuclei close to A=80 have been investigated at the IGISOL facility. The studied nuclei, 81Y, 81Sr, 81mKr, 85Nb, 85Zr, 86Mo and 86Nb, were produced by a 32S beam from the Jyv?skyl? isochronous cyclotron on 54Fe and natNi targets. The internal conversion coefficient for a 190.5 keV isomeric transition in 81mKr has been measured and the internal transition rate has been determined. The internal transition rate has been used to estimate
a neutrino capture rate on 81Br, which yields a log ft of 5.13±0.09 for the reaction 81Br( ν, e
-)81mKr. A new isomer with a half-life of 3.3±0.9 s has been observed in 85Nb. The existence of an earlier reported isomer with a half-life of 56 s in 86Nb has not been confirmed. 相似文献
9.
10.
Electronic properties of model quantum-dot structures in zero and finite magnetic fields 总被引:1,自引:0,他引:1
H. Saarikoski E. Räsänen S. Siljamäki A. Harju M.J. Puska R.M. Nieminen 《The European Physical Journal B - Condensed Matter and Complex Systems》2002,26(2):241-252
We have computed electronic structures and total energies of circularly confined two-dimensional quantum dots and their lateral
dimers in zero and finite uniform external magnetic fields using different theoretical schemes: the spin-density-functional
theory (SDFT), the current-and-spin-density-functional theory (CSDFT), and the variational quantum Monte Carlo (VMC) method.
The SDFT and CSDFT calculations employ a recently-developed, symmetry-unrestricted real-space algorithm allowing solutions
which break the spin symmetry. Results obtained for a six-electron dot in the weak confinement limit and in zero magnetic
field as well as in a moderate confinement and in finite magnetic fields enable us to draw conclusions about the reliability
of the more approximative SDFT and CSDFT schemes in comparison with the VMC method. The same is true for results obtained
for the two-electron quantum dot dimer as a function of inter-dot distance. The structure and role of the symmetry-breaking
solutions appearing in the SDFT and CSDFT calculations for the above systems are discussed.
Received 16 October 2001 and Received in final form 17 January 2002 相似文献