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排序方式: 共有427条查询结果,搜索用时 16 毫秒
1.
Separation of cannabinoids on three different mixed‐mode columns containing carbon/nanodiamond/amine‐polymer superficially porous particles 下载免费PDF全文
Chuan‐Hsi Hung Janusz Zukowski David S. Jensen Andrew J. Miles Clayton Sulak Andrew E. Dadson Matthew R. Linford 《Journal of separation science》2015,38(17):2968-2974
Three mixed‐mode high‐performance liquid chromatography columns packed with superficially porous carbon/nanodiamond/amine‐polymer particles were used to separate mixtures of cannabinoids. Columns evaluated included: (i) reversed phase (C18), weak anion exchange, 4.6 × 33 mm, 3.6 μm, and 4.6 × 100 mm, 3.6 μm, (ii) reversed phase, strong anion exchange (quaternary amine), 4.6×33 mm, 3.6 μm, and (iii) hydrophilic interaction liquid chromatography, 4.6 × 150 mm, 3.6 μm. Different selectivities were achieved under various mobile phase and stationary phase conditions. Efficiencies and peak capacities were as high as 54 000 N/m and 56, respectively. The reversed phase mixed‐mode column (C18) retained tetrahydrocannabinolic acid strongly under acidic conditions and weakly under basic conditions. Tetrahydrocannabinolic acid was retained strongly on the reversed phase, strong anion exchange mixed‐mode column under basic polar organic mobile phase conditions. The hydrophilic interaction liquid chromatography column retained polar cannabinoids better than the (more) neutral ones under basic conditions. A longer reversed phase (C18) mixed‐mode column (4.6 × 100 mm) showed better resolution for analytes (and a contaminant) than a shorter column. Fast separations were achieved in less than 5 min and sometimes 2 min. A real world sample (bubble hash extract) was also analyzed by gradient elution. 相似文献
2.
Juan Pablo Vielma Iain Dunning Joey Huchette Miles Lubin 《Mathematical Programming Computation》2017,9(3):369-418
In this paper we consider the use of extended formulations in LP-based algorithms for mixed integer conic quadratic programming (MICQP). Extended formulations have been used by Vielma et al. (INFORMS J Comput 20: 438–450, 2008) and Hijazi et al. (Comput Optim Appl 52: 537–558, 2012) to construct algorithms for MICQP that can provide a significant computational advantage. The first approach is based on an extended or lifted polyhedral relaxation of the Lorentz cone by Ben-Tal and Nemirovski (Math Oper Res 26(2): 193–205 2001) that is extremely economical, but whose approximation quality cannot be iteratively improved. The second is based on a lifted polyhedral relaxation of the euclidean ball that can be constructed using techniques introduced by Tawarmalani and Sahinidis (Math Programm 103(2): 225–249, 2005). This relaxation is less economical, but its approximation quality can be iteratively improved. Unfortunately, while the approach of Vielma, Ahmed and Nemhauser is applicable for general MICQP problems, the approach of Hijazi, Bonami and Ouorou can only be used for MICQP problems with convex quadratic constraints. In this paper we show how a homogenization procedure can be combined with the technique by Tawarmalani and Sahinidis to adapt the extended formulation used by Hijazi, Bonami and Ouorou to a class of conic mixed integer programming problems that include general MICQP problems. We then compare the effectiveness of this new extended formulation against traditional and extended formulation-based algorithms for MICQP. We find that this new formulation can be used to improve various LP-based algorithms. In particular, the formulation provides an easy-to-implement procedure that, in our benchmarks, significantly improved the performance of commercial MICQP solvers. 相似文献
3.
J.P. Miles 《Journal of the mechanics and physics of solids》1973,21(3):145-162
An analysis is presented of an eigenstate that may be significant in deformation processes where part of the surface of a body is subjected to loading by uniform fluid pressure. The ‘fluid-pressure eigenstate’ is a configuration in which quasi-static incremental deformation is possible under surface traction-rates that are related to the instantaneous velocity field in a certain way, the fluid pressure being momentarily stationary. Deformation processes exist such that, given certain rate boundary-conditions, uniqueness of the incremental deformation is guaranteed at every instant up to a fluid-pressure eigenstate. For a cylindrical specimen, of arbitrary cross-section, of elastic/plastic or incompressible, finite elastic material it is shown that the first fluid-pressure eigenstate to be reached on a path of uniform stretching corresponds to the instant at which the ‘effective load’ reaches a maximum. No fluid-pressure eigenstates are reached in isotropic Cauchy-elastic solids under all-round fluid pressure loading provided the physically reasonable conditions that the instantaneous bulk and shear moduli remain positive are satisfied. 相似文献
4.
We present experimental results using Filtered Rayleigh Scattering to make planar measurements of velocity, temperature and
pressure in ambient air and in a Mach 2 free jet. The ambient air measurements are used to identify and calibrate experimental
uncertainties. The Mach 2 measurements demonstrate the usefulness of the technique for making accurate planar measurements
in a high speed flow. The measured values for velocity, temperature and pressure in the Mach 2 jet ranged, through a shock
system, from 205 to 235 m/s, 150 to 170 K and 700 to 1000 torr, with estimated uncertainties of ±5.4 m/s, ±3.2 K and ±38 torr
(±2 to 3%, ±2% and ±4–5%, respectively).
Received: 10 December 1996/Accepted: 14 July 1997 相似文献
5.
6.
The phase transformation from the tetragonal to the hexagonal crystal modification in highly oriented lamellae of poly-butene-1 has been followed by transmission electron microscopy (TEM). It is found that the reaction-controlling step is the nucleation process. No lattice orientation relationship (besides the [001]-direction, which is parallel in both crystal modifications) exists between non-transformed and transformed crystals. The nucleation is strongly enhanced by thermal or external stresses. Crystal growth, nucleated by external stresses, was observed at temperatures as low as — 150°C. The molecular mechanisms of the transformation are discussed. 相似文献
7.
M.R. Trantham C.C. Kuranz G. Malamud M.J. Grosskopf E.S. Myra R.P. Drake A.R. Miles H.-S. Park B.A. Remington 《High Energy Density Physics》2013,9(2):303-308
Future experiments at the National Ignition Facility will be able to generate diagnosable Rayleigh–Taylor instability growth in the presence of locally generated, high radiation fluxes. This interplay of radiative energy transfer and hydrodynamic instability is relevant to many astrophysical systems, such as core-collapse red supergiant supernovae. Previous simulations of high-energy-density Rayleigh–Taylor instabilities in the presence of a hot environment near a radiative shock demonstrate behavior that differs from that found in non-radiative cases. However, these simulations considered only 1D or single wavelength cases. Here we report simulations of an entire experimental system using the CRASH code. These simulations lead to modified predictions, attributed to the effects of radial energy losses. 相似文献
8.
Willem Jespers Dr. Grégory Verdon Dr. Jhonny Azuaje Dr. Maria Majellaro Dr. Henrik Keränen Prof. Xerardo García-Mera Dr. Miles Congreve Dr. Francesca Deflorian Dr. Chris de Graaf Dr. Andrei Zhukov Dr. Andrew S. Doré Dr. Jonathan S. Mason Prof. Johan Åqvist Dr. Robert M. Cooke Prof. Eddy Sotelo Dr. Hugo Gutiérrez-de-Terán 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(38):16679-16686
We present a robust protocol based on iterations of free energy perturbation (FEP) calculations, chemical synthesis, biophysical mapping and X-ray crystallography to reveal the binding mode of an antagonist series to the A2A adenosine receptor (AR). Eight A2AAR binding site mutations from biophysical mapping experiments were initially analyzed with sidechain FEP simulations, performed on alternate binding modes. The results distinctively supported one binding mode, which was subsequently used to design new chromone derivatives. Their affinities for the A2AAR were experimentally determined and investigated through a cycle of ligand-FEP calculations, validating the binding orientation of the different chemical substituents proposed. Subsequent X-ray crystallography of the A2AAR with a low and a high affinity chromone derivative confirmed the predicted binding orientation. The new molecules and structures here reported were driven by free energy calculations, and provide new insights on antagonist binding to the A2AAR, an emerging target in immuno-oncology. 相似文献
9.
10.
As a result of a continuing study utilizing nitrogenous bases2–6, we now wish to report that the base 3-quinuclidinol (13) is useful for the cleavage of β-keto and vinylogous β-keto esters. 相似文献