Random Copolymers of 1,5-Dioxepan-2-one

ABSTRACT

Copolymers of 1,5-dioxepan-2-one (DXO) and e-caprolactone (?-CL), δ-valerolactone (δ-VL) or L-lactide (LLA) have been synthesized and characterized. High molecular weight copolymers were obtained using stannous-2-ethyl hexanoate as catalyst in bulk. Reactivity ratios for the copolymerization of DXO and δ-VL were determined at 110°C as r_VL=0.5 and r_DXO=2.3. At high conversion, depolymerization of δ-VL occurred, resulting in lower molecular weight and variations in the copolymer composition.

Physical properties, such as crystallinity and melting temperature of the DXO-copolymers proved to be strongly dependent on the choice of comonomer and on the molar composition of the copolymers. DXO appears to be incorporated into the poly-?-caprolactone (PCL) crystals and to some extent into the poly-δ-valerolactone (PVL) crystals, resulting in a more gradual decrease in crystallinity with increasing amount of DXO.     

Nanoporous polyimide film from poly(ethylene glycol-co-imide) using a one-step heat calcination process

Polyamic acid (PAA) made from 3,3, 4,4-biphenyltetracarboxylic dianhydride and 4,4-diaminodiphenyl ether was synthesized and used as the backbone of nanoporous polyimide. Thermally labile polyethylene glycol (PEG) at 10, 20 or 30 wt% was introduced to the end group of PAA. Self-assembled PAA-b-PEG micelle-like nanoparticles could be formed as a result of amphiphilic characteristics of hydrophobic PAA and hydrophilic PEG. Thermal imidization and degradation of spin-coated amphiphilic PAA-b-PEG film were performed sequentially through one-step heat treatment to obtain polyimide film with nanopores. Pore sizes decreased with increasing amount of PEG block and their dielectric constants decreased from 2.71 ± 0.13 to 2.38 ± 0.11.     

Determination of PF‐04620110, a novel inhibitor of diacylglycerol acyltransferase‐1, in rat plasma using liquid chromatography–tandem mass spectrometry and its application in pharmacokinetic studies

In this study, we developed a method for the determination of PF‐04620110 (2‐{(1r,4r)‐4‐[4‐(4‐amino‐5‐oxo‐7,8‐dihydropyrimido[5,4‐f][1,4]oxazepin‐6(5H)‐yl)phenyl]cyclohexyl}acetic acid), a novel diacylglycerol acyltransferase 1 (DGAT‐1) inhibitor, in rat plasma and validated it using liquid chromatography–tandem mass spectrometry (LC‐MS/MS). Rat plasma samples were processed following a protein precipitation method by using acetonitrile and were then injected into an LC‐MS/MS system for quantification. PF‐04620110 and imipramine (internal standard) were separated using a Hypersil Gold C₁₈ column, with a mixture of acetonitrile and 10 mm ammonium formate (90:10, v/v) as the mobile phase. The ion transitions monitored in positive‐ion mode [M + H]⁺ of multiple‐reaction monitoring were m/z 397.0 → 260.2 for PF‐04620110 and m/z 280.8 → 86.0 for imipramine. The detector response was specific and linear for PF‐04620110 at concentrations within the range 0.05–50 µg/mL and the signal‐to‐noise ratios for the samples were ≥10. The intra‐ and inter‐day precision and accuracy of the method matched the acceptance criteria for assay validation. PF‐04620110 was stable under various processing and/or handling conditions. PF‐04620110 concentrations in the rat plasma samples could be measured up to 24 h after intravenous or oral administration of PF‐04620110, suggesting that the assay is useful for pharmacokinetic studies in rats. Copyright © 2013 John Wiley & Sons, Ltd.     

Study on the BODIPY-triazine-based tripod fluorescent systems: various structures from similar procedure

We report a small library of fluorophore-triazine tripod fluorescent system that can accommodate a combination of three different functional groups, such as fluorophore (BODIPY), ligand (or ligands) and auxiliary group. Syntheses, photophysical properties as well as binding properties towards metal ions of these BODIPY-triazine derivatives are described.