Einwirkung von p-Nitroso-dimethylanilin auf Brenztraubensäure und ihre Derivate, 6. Mitt.: Kondensation der Phenylbrenztraubensäure mit primären aromatischen Aminen

Phenylpyruvic acid reacts with p-nitroaniline to yield the 3-hydroxypyrrolinone2a, and with anilines bearing+M substituents in the p-position to yield the 3-enaminopyrrolinones1b-1e.

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5. Mitt.:M. Ruse, E. Hamburg undM. Petri, Chem. Ber.103, 3727 (1970).     

On the Effects of UV Radiation on the Release Ability of Glucose Embedded in Hydroxypropyl Cellulose Films

New drug delivery systems based on hydroxypropyl cellulose (HPC) and different percents of glucose were prepared and characterized to check their suitability as UV resistant patches. The spectral absorption properties of the HPC and HPC-glucose blends before and after UV irradiation were analyzed. The surface polarity and hydrophilicity were correlated with the morphology of the films and analyzed with respect to the UV exposure time and the embedded amount of glucose. The effects of UV radiation on in vitro evaluation of glucose release from the HPC films are reported. The mechanism involved in the drug release process, evaluated using the Korsmeyer-Peppas equation, was dependent on the introduced amount of glucose and less on the UV exposure time. A more polar, smoother, and less dense surface releases the glucose over larger periods of time, making the system with lower percents of glucose more adequate for the pursued purpose.     

Affinity capillary electrophoresis to evaluate the complex formation between poliovirus and nanobodies

It was demonstrated that nanobodies with an in vitro neutralizing activity against poliovirus type 1 interact with native virions. Here, the use of capillary electrophoresis was investigated as an alternative technique for the evaluation of the formation of nanobody–poliovirus complexes, and therefore predicting the in vitro neutralizing activity of the nanobodies. The macromolecules are preincubated offline in a specific nanobody‐to‐virus ratio and analyzed by capillary electrophoresis with UV detection. At low nanobody‐to‐virus ratios, a clear shift in migration time of the viral peak was observed. A broad peak was obtained, indicating the presence of a heterogeneous population of nanobody–virion complexes, caused by the binding of different numbers of nanobodies to the virus particle. At elevated nanobody‐to‐virus ratios, a cluster of peaks appeared, showing an additional increase in migration times. It was shown that, at these high molar excesses, aggregates were formed. The developed capillary electrophoresis method can be used as a rapid, qualitative screening for the affinity between poliovirus and nanobodies, based on a clearly visible and measurable shift in migration time. The advantages of this technique include that there is no need for antigen immobilization as in enzyme‐linked immunosorbent assays or surface plasmon resonance for the use of radiolabeled virus or for the performance of labor‐ and time‐intensive plaque‐forming neutralization assays.     

Wastes from Wood Extraction Used in Composite Materials: Behavior after Accelerated Weathering

New materials were obtained by incorporating in polypropylene (PP) matrix 60% wood wastes resulting after extraction with supercritical carbon dioxide, water, and ethanol. Structural, mechanical, thermal, and rheological characterizations, as well as moisture uptake of the composites, were evaluated before and after accelerated weathering. It was found that the extraction method influenced the composite properties due to the hydrophilic-hydrophobic balance. The addition of extracted fibers results in an increase in hardness and tensile properties and a decrease of impact strength as compared to PP.     

Gold layers on untreated and plasma-treated substrates of quaternized polysulfones

Thin gold layers were sputtered on the quaternized polysulfones (containing different tertiary amines—N,N-dimethylethylamine and N,N-dimethyloctylamine, respectively) surfaces unmodified and modified by low-pressure and high-frequency plasma treatment. Adhesion and morphological aspects of complex structures were studied for different gold sputtering and plasma treatment times. Water contact angle, atomic force microscopy, and surface properties reveal that adhesion increases with gold sputtering and plasma treatment times. Values of the mean adhesion force between cantilever and the studied surfaces, measured from AFM investigation, were correlated with quaternized polysulfone structures, modification of hydrophobicity after plasma treatment, and gold deposition on polymer surfaces.     

Study of 19Na at SPIRAL

The excitation function for the elastic-scattering reaction p( ¹⁸Ne, p) ¹⁸Ne was measured with the first radioactive beam from the SPIRAL facility at the GANIL laboratory and with a solid cryogenic hydrogen target. Several broad resonances have been observed, corresponding to new excited states in the unbound nucleus ¹⁹Na. In addition, two-proton emission events have been identified and are discussed.     

Beta-decay of 71Co and 73Co

A decay spectroscopy study of the neutron-rich cobalt isotopes has been performed using fragmentation of a ⁸⁶Kr³⁶⁺ beam and the new LISE2000 spectrometer at GANIL. For ⁷¹Co and ⁷³Co, the -delayed radiation has been observed for the first time, and the half-lives were found to be 79(5) ms and 41(4) ms, respectively. Features of the decay are discussed qualitatively in terms of nuclear models.