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1.
Quantitative determination of omega-6 and omega-3 polyunsaturated fatty acids in human plasma and urine with high accuracy and precision provides significant information to monitor the underlying etiology of several diseases. In this regard, liquid chromatography-mass spectrometry is a good choice owing to its great selectivity and sensitivity. Additionally, the hybrid quadrupole–time of flight–mass spectrometer systems provides easy identification of target compounds with superior mass measurements. In this study, an analytical method has been developed for simple, accurate and simultaneous determination of linoleic acid, arachidonic acid, docosahexaenoic acid and eicosapentaenoic acid in a short chromatographic analysis period. The developed method is suitable for the quantitative detection of these four compounds with detection limits ranging between 1.1–3.0 ng ml−1 and its applicability was assessed in human urine and plasma samples. As a result, acceptable accuracy (between 83 and 111%) and good precision (<6%) were obtained for target compounds using matrix matching calibration strategy. 相似文献
2.
This paper describes a novel approach to detect Cd(II) using the combination of the differential pulse anodic stripping voltammetry and magnetic nanoparticle based dispersive solid phase microextraction as an efficient, green and accurate method. Currents of Cd(II) increased linearly in the range from 75 to 2000 ng L−1 Cd(II) with a detection limit of 21.6 ng L−1. The RSD values of 2.6 and 6.0 % for 1.00 and 0.10 μg L−1 respectively showed that proposed method has an acceptable repeatability. Recovery values between 92.3 and 98.6 % showed that this approach can be successfully used for determination of Cd(II) in water samples. 相似文献
3.
Ilkay Bak?rta? 《International Journal of Non》2005,40(6):785-793
In the present work, treating the artery as a tapered, thin walled, long and circularly conical prestressed elastic tube and using the longwave approximation, we have studied the propagation of weakly non-linear waves in such a fluid-filled elastic tube by employing the reductive perturbation method. By considering the blood as an incompressible inviscid fluid, the evolution equation is obtained as the Korteweg-de Vries equation with a variable coefficient. It is shown that this type of equation admits a solitary wave-type solution with variable wave speed. It is observed that, the wave speed decreases with distance for positive tapering while it increases for negative tapering. It is further observed that, the progressive wave profile for expanding tubes (a>0) becomes more steepened whereas for narrowing tubes (a<0) it becomes more flattened. 相似文献
4.
B. Bak 《Molecular physics》2013,111(4):373-375
By means of microwave spectra of six isotopic pyridines and dipole moment and proton magnetic resonance data the magnitude of the charges on the carbon atoms of pyridine is estimated. Each of the ortho carbon atoms has a charge of ca. +0·08 e, the meta atoms are uncharged, while the para carbon atom has a charge of ca. 0·04 e. The result is in rough agreement with quantum-mechanical estimates. 相似文献
5.
6.
Masoud Behzad Karel Samec Sang-In Bak Yacine Kadi Claudio Tenreiro Seung-Woo Hong Jong-Seo Chai 《Journal of Radioanalytical and Nuclear Chemistry》2014,299(2):1001-1006
A worldwide challenge in the near future will be to find a way of producing radioisotopes in sufficient quantity without relying on research reactors. The motivation for this innovative work on targets lies in the accelerator-based production of radioisotopes using a neutron converter target as in the transmutation by adiabatic resonance crossing concept. Thermal analysis of a multi-channel helium cooled device is performed with the computational fluid dynamics code CFX. Different boundary conditions are taken into account in the simulation process and many important parameters such as maximum allowable solid target temperature as well as uniform inlet velocity and outlet pressure changes in the channels are investigated. The results confirm that the cooling configuration works well; hence such a solid target could be operated safely and may be considered for a prototype target. 相似文献
7.
8.
Electrical properties of TiO<Subscript>2</Subscript>: equilibrium vs dynamic electrical conductivity
The present work reports semiconducting properties of high purity TiO2 determined in the gas/solid equilibrium, as well as during controlled heating and cooling in the range 300–1,273 K. The activation
energy of the electrical conductivity is considered in terms of the activation enthalpy of the formation of ionic defects
and the activation enthalpy of the mobility of electronic defects. These data, determined from the dynamic electrical conductivity
experiments, are compared to the electrical conductivity data determined in equilibrium. It is shown that only the equilibrium
electrical conductivity data for high-purity TiO2 are well defined. It is shown that the activation energy of the electrical conductivity determined in equilibrium differs
substantially from that for the dynamic electrical conductivity data during cooling and heating. It is concluded that the
formation enthalpy term determined from the dynamic conductivity data is determined by the heating/cooling rate rather than
materials’ properties. 相似文献
9.
Attila Makó Zsolt Rapi György Keglevich Áron Szöllősy László Drahos László Hegedűs Péter Bakó 《Tetrahedron: Asymmetry》2010,21(8):919-925
The chiral monoaza-15-crown-5 lariat ethers annellated to methyl-4,6-O-benzylidene-α-d-glucopyranoside-1 or mannopyranoside 2 have been applied as phase-transfer catalysts in the epoxidation of substituted chalcones and chalcone analogues with tert-butylhydroperoxide resulting in significant asymmetric induction. It was found that the position of the substituents in the aromatic ring of the chalcone had an influence both on the chemical yields and enantiomeric excesses. The lowest enantioselectivities (62–83% ee) were found in the case of ortho-substituted model compounds. The highest ee values (ee of 83–97%) were obtained in the case of para-substituted models. From among the chalcone analogues, the maximum ee (90–92%) was detected for the model compound having α-tert-butyl- and β-aryl groups. Using glucose-based crown ether 1, formation of the (?)-enantiomer was preferred, while applying mannose-based 2 as the catalyst, the (+)-enantiomer was in excess. 相似文献
10.
Erick Kindt Sandra Bak Mueller Christine Castle Carine M. Boustany‐Kari 《Biomedical chromatography : BMC》2010,24(7):752-758
Biomarkers are an increasingly important constituent of the drug development process, offering the potential of increased efficiency through reduced compound attrition and earlier proof of mechanism and/or efficacy. Assays developed for compound screening that can be directly translated for clinical trials are especially valuable, but their successful adoption requires a careful balance between assay performance and implementation costs. One such ‘fit‐for‐purpose’ biomarker assay, the indirect measurement of pharmacological modulation of sphingolipid biosynthesis and disposition, is presented here. Among spingolipids, numerous ceramide species are readily detectable in different lipoprotein fractions of mammalian plasma, but their parallel quantification can be prohibitively expensive and time consuming. Ceramides differ in their fatty acid moiety, which is readily removed by hydrolysis, yielding a common sphingosine derivative, the measurement of which serves as an indicator of total ceramide. When followed by liquid chromatography tandem mass spectrometry (LC/MS/MS) for detection, robust analyte quantification becomes relatively straightforward. The practical utility of a method developed to be fit for the purpose of rapidly and quantitatively measuring treatment‐induced variations in total ceramide from hamster plasma and individual lipoprotein fractions is described. With a linear calibration range from 0.003 to 33.4 μm sphingosine, precision and accuracy error in plasma‐based quality controls spiked with ceramides was less than 15%. The specificity of the assay for ceramides was also assessed. The simplicity of the method would allow for its potential translation to other preclinical species, as well as for clinical applications in later‐stage drug development. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献