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1.
Combating Multidrug‐Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials
Dr. Kieron M. G. O'Connell Dr. James T. Hodgkinson Dr. Hannah F. Sore Dr. Martin Welch Prof. George P. C. Salmond Dr. David R. Spring 《Angewandte Chemie (International ed. in English)》2013,52(41):10706-10733
The introduction of effective antibacterial therapies for infectious diseases in the mid‐20th century completely revolutionized clinical practices and helped to facilitate the development of modern medicine. Many potentially life‐threatening conditions became easily curable, greatly reducing the incidence of death or disability resulting from bacterial infections. This overwhelming historical success makes it very difficult to imagine life without effective antibacterials; however, the inexorable rise of antibiotic resistance has made this a very real and disturbing possibility for some infections. The ruthless selection for resistant bacteria, coupled with insufficient investment in antibacterial research, has led to a steady decline in the efficacy of existing therapies and a paucity of novel structural classes with which to replace them, or complement their use. This situation has resulted in a very pressing need for the discovery of novel antibiotics and treatment strategies, the development of which is likely to be a key challenge to 21st century medicinal chemistry. 相似文献
2.
Roy Hodgkinson Václav Jurčík Hans Nedden Andrew Blackaby Martin Wills 《Tetrahedron letters》2018,59(10):930-933
A new route towards a series of tethered η6-arene/Ru(II) catalysts for use in the transfer and pressure hydrogenation of ketones and aldehydes to alcohols is reported. The route proceeds through the formation of an amide from the diamine precursor, followed by reduction, rather than the direct alkylation of the diamine. This has the advantage that dialkylation of the amine is avoided during the synthesis. Through this new route, both racemic and enantiomerically-pure η6-arene/Ru(II) tethered catalysts can be prepared in high yield. 相似文献
3.
Daniel T. W. Toolan Richard Hodgkinson Jonathan R. Howse 《Journal of Polymer Science.Polymer Physics》2014,52(1):17-25
Spin‐coated polymer blends possess a rich variety of accessible non‐equilibrium morphologies, formed through a process of phase separation and self‐assembly, the complexities of which remain incompletely understood. The technique of stroboscopic microscopy has now been developed to allow direct observations of microscopic and mesoscopic morphological development during spin‐coating and has afforded unequivocal information regarding morphological development. The technique so far has three modes of operation providing information on topographical, compositional, and crystal development. In this review, we look at the technique's development, its applications and comment on the future potential for this technique. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014 , 52, 17–25 相似文献
4.
Effects of Quantum Nuclear Delocalisation on NMR Parameters from Path Integral Molecular Dynamics 下载免费PDF全文
Dr. Martin Dračínský Dr. Paul Hodgkinson 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(8):2201-2207
The influence of nuclear delocalisation on NMR chemical shifts in molecular organic solids is explored using path integral molecular dynamics (PIMD) and density functional theory calculations of shielding tensors. Nuclear quantum effects are shown to explain previously observed systematic deviations in correlations between calculated and experimental chemical shifts, with particularly large PIMD‐induced changes (up to 23 ppm) observed for carbon atoms in methyl groups. The PIMD approach also enables isotope substitution effects on chemical shifts and J couplings to be predicted in excellent agreement with experiment for both isolated molecules and molecular crystals. An approach based on convoluting calculated shielding or coupling surfaces with probability distributions of selected bond distances and valence angles obtained from PIMD simulations is used to calculate isotope effects. 相似文献
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W. R. Hodgkinson 《Fresenius' Journal of Analytical Chemistry》1896,35(1):552
Ohne Zusammenfassung 相似文献
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Ohne Zusammenfassung 相似文献
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Ambichiral layered structures can be designed to function reasonably well as rejection filters for elliptical polarization states, although the proposed design strategy is inadequate for linear and quasilinear polarization states. 相似文献
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A kinetic spectrophotometric technique, employing a Q-switched, frequency-doubled ruby laser as the excitation source, has been used to determine the short-lived (S1 → Sp), and long-lived (T1 → Tq) transient absorption spectra of several benzenoid aromatic hydrocarbons. The excited singlet states determined in this way are compared with the singlet states observed by absorption from the ground state (S0 → Sn). Some previously assigned triplet states are reassigned as singlet levels. 相似文献