Synthesis and Antiproliferative Activity of Novel Hydrazono Thiazolidene and Thiazole Derivatives Bearing Rhodanine Moiety

Russian Journal of General Chemistry - Some new fluoro-heterocyclic compounds containing thiazole and pyridine moities have been synthesized and studied for their antiproliferative activity....     

Synthesis and characterization studies of 3-formyl chromone Schiff base complexes and their application as antitumor,antioxidant and antimicrobial

A novel Schiff base namely (E)-3-((2,6-dihydroxypyrimidin-4-ylimino)methyl)-4H-chromen-4-one and its Co (II), N (II)i, Cu (II) and Cd (II) complexes have been synthesized and proved by elemental analysis, molar conductance, thermal analysis (TGA), Inductive Coupled plasma (ICP), magnetic moment measurements, X-ray powder diffraction, IR, EI-mass,¹H NMR, ¹³C NMR,UV–Vis. and ESR spectral studies. On the basis of these data, it is evident that the Schiff base acts as bidentate via oxygen atom of carbonyl group and azomethine nitrogen atom for Co (II) complex; monobasic bidentate ligand for Ni (II), Cu (II) and Cd (II) complexes via oxygen atom of hydroxyl group and nitrogen atom of pyrimidine ring. The results showed all complexes have octahedral geometry. The average particle size of the ligand and its complexes were found to be 1.010–0.343 nm. The pharmacological action (antioxidant, antimicrobial and anticancer) of the prepared compounds is studied. The antitumor activity of the ligand and its metal complexes is evaluated against human liver carcinoma (HEPG2) cell. The data displayed the Co (II) complexes strong cytotoxicity where IC₅₀ values of Co (II) complex and 5-fluorouracil (stander drug) are 9.33 and 7.86 μg/ml respectively. The Co (II) and Cd (II) complexes have antibacterial activity more than ampicillin (stander drug). The interaction of the synthesized compounds with calf-thymus DNA (CT-DNA) has been performed via absorption spectra and viscosity technique. The DNA- binding constants have been determined.     

Numerical algorithm for solving multi-pantograph delay equations on the half-line using Jacobi rational functions with convergence analysis

A new spectral Jacobi rational-Gauss collocation (JRC) method is proposed for solving the multi-pantograph delay differential equations on the half-line. The method is based on Jacobi rational functions and Gauss quadrature integration formula. The main idea for obtaining a semi-analytical solution for these equations is essentially developed by reducing the pantograph equations with their initial conditions to systems of algebraic equations in the unknown expansion coefficients. The convergence analysis of the method is analyzed. The method possesses the spectral accuracy. Numerical results indicating the high accuracy and effectiveness of this algorithm are presented. Indeed, the present method is compared favorably with other methods.     

A strict topology on Orlicz spaces

Let φ be a Young function, Ω be a locally compact space, and μ be a positive Radon measure on Ω. We consider a strict topology (in the sense of Sentilles‐Taylor) on the Orlicz function space and investigate various properties of this locally convex topology. We also study the Orlicz space of a locally compact group G with a left Haar measure under the strict topology and certain other natural locally convex topologies. Finally we present some results on various continuity properties of convolution operators on under the topology and other natural ones.     

Synthesis of star-shaped CuO nanoparticles supported on magnetic functionalized graphene: Catalytic and antibacterial activity

In this study, graphene oxide was modified during consecutive functionalization steps with 1,4-diphenylamine, cyanuric chloride, and ethylenediamine. Then, star-shaped CuO nanoparticles were synthesized on modified graphene oxide using the seed-mediated growth method in which nucleation, growth stages, and reduction of graphene oxide to graphene occurred simultaneously. After ensuring successful synthesis of CuO nanoparticles and to facilitate recycling, a magnetization process was utilized by adding iron oxide nanoparticles. This nanocomposite was characterized by transmission electron microscopy, X-ray powder diffraction, scanning electron microscopy, and Fourier transform infrared spectroscopy. The prepared heterogeneous catalyst was investigated for the reduction of organic dyes in the presence of NaBH₄ as a reducing reagent. The kinetic data obtained for the reduction of methyl orange (MO), methylene blue (MB), 4-nitrophenol (4-NP), and rhodamine 6G (Rh6G) were fitted to first-order rate equations, and the calculated rate constants for the reduction of MO, MB, 4-NP and Rh6G were as follows: −0.091, −0.071, −0.045, and 0.040, respectively. As star-shaped CuO nanoparticles showed a higher antibacterial effect compared to spherical-shaped CuO nanoparticles, the antibacterial activity of star-shaped CuO nanoparticles immobilized on magnetic functionalized graphene was evaluated against Gram-positive and Gram-negative bacteria through an agar well diffusion assay and demonstrated more antibacterial activity against gram-positive bacteria.     

Uniqueness of uniform norm and C*-norm in L p (G, ω)

Let G be a locally compact abelian group with a fixed Haar measure and ω be a weight on G. For 1 < p < ∞, we study uniqueness of uniform and C*-norm properties of the invariant weighted algebra L ^p (G, ω).     

New Numerical Approach for Fractional Variational Problems Using Shifted Legendre Orthonormal Polynomials

This paper reports a new numerical approach for numerically solving types of fractional variational problems. In our approach, we use the fractional integrals operational matrix, described in the sense of Riemann–Liouville, with the help of the Lagrange multiplier technique for converting the fractional variational problem into an easier problem that consisting of solving an algebraic equations system in the unknown coefficients. Several numerical examples are introduced, combined with their approximate solutions and comparisons with other numerical approaches, for confirming the accuracy and applicability of the proposed approach.     

Novel Syntheses and Reactions of Polynuclear Heterocyclic Derivatives Derived From Thioxopyridopyrimidine,With a New Ring System

Pyridopyrimidine derivatives 2 reacted with hydrazonoylchloride derivatives and yielded triazolopyridopyrimidines 6a–f. Compound 4b reacted with aliphatic acids and afforded triazolo-pyridopyrimidines 7a,b, and the reaction with carbon disulfide afforded 10-mercapto-triazolopyridopyrimidine (10). Moreover, the reaction of 4b with β -ketoesters afforded 10-pyrazolyl-pyridopyrimidines derivatives 11, 13, 14, and 15. Compound 4b reacted with nitrous acid to give tetrazolopyridopyrimidine 16, which reduced to 10-amino-derivative 17. On the other hand, the reaction of 4b with aromatic aldehydes afforded arylidines derivatives 18a–c, which were later cyclized to triazolo-pyridopyrimidines deivatives 19a–c. Finally, 4b reacted with α-haloketones to give triazines derivativrs 20, with new ring systems.     

SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME NEW 8-HYDROXYQUINOLINE SULPHONAMIDE DERIVATIVES

Abstract

Some new derivatives containing both 8-hydroxyquinoline and sulphonylamino β-lactams and thiazolidinones have been prepared. These compounds were synthesized from the corresponding 8-hydroxyquinoline sulphonylhydrazide (1) by converting it to hydrazones (2). The latter hydrazones (2) were easily transformed to β-lactams (3) and thiazolidinones (4) by cyclocondensation reaction with chloroacetyl chloride and/or mercaptoacetic acid. Some metal chelates with Fe³⁺. Co²⁺+, Ni²⁺, Cu²⁺ and Cd²⁺ have been prepared for some of the compounds and screened in vitro for their biological activity.     

Calculation of viscosity–temperature curves for glass obtained from four wastewater treatment plants in Egypt

This article establishes the relationship between the chemical composition, temperature and viscosity of glasses obtained from the four sludge treatment plants of urban and industrial wastewater from the Nile Delta in Egypt. In order to determine the working conditions of these glasses and their growth temperature, different techniques have been used: differential thermal analysis, hot stage microscopy and dilatometry. We used a prototype of hot stage microscopy, with the help of an image analysis programme developed in the present study. The chemical composition of major oxides sludge ranging from: SiO₂ (36–48 wt%), Al₂O₃ (9–16 wt%), CaO (5–25 wt%), P₂O₅ (1.5–11 wt%), and Fe₂O₃ (~9 wt%), this composition is close to a basalt rock, being necessary to incorporate some raw materials to adjust it to the basalt rock that has a good viscosity-temperature curve. The glass transition temperatures of the four glasses obtained vary between 650 and 725 °C and the growth occurs between 938 and 1,033 °C. We also obtained the viscosity–temperature curves with the aid of the hot stage microscopy that has allowed us to determine the working temperatures of the four glasses, ranging from 926 to 1,419 °C, depending on the type of forming process used.