Newtonian plane Couette flow with dynamic wall slip

Meccanica - The occurrence of slip complicates the estimation of the viscosity in rheometric flows. Thus, special analyses and experimental protocols are needed in order to obtain reliable...     

A far-red emitting probe for unambiguous detection of mobile zinc in acidic vesicles and deep tissue

Imaging mobile zinc in acidic environments remains challenging because most small-molecule optical probes display pH-dependent fluorescence. Here we report a reaction-based sensor that detects mobile zinc unambiguously at low pH. The sensor responds reversibly and with a large dynamic range to exogenously applied Zn²⁺ in lysosomes of HeLa cells, endogenous Zn²⁺ in insulin granules of MIN6 cells, and zinc-rich mossy fiber boutons in hippocampal tissue from mice. This long-wavelength probe is compatible with the green-fluorescent protein, enabling multicolor imaging, and facilitates visualization of mossy fiber boutons at depths of >100 μm, as demonstrated by studies in live tissue employing two-photon microscopy.     

Heat transfer due to harmonic variation in the free stream temperatures in a flat plate exposed on both sides

The heat transfer through an infinite flat plate is studied when the temperatures of the two free streams surrounding it are varying harmonically with time and out of phase, with a delay period τ_d. The configuration is a simplified model for the heat transfer through the separating wall in the isochoric counter-current heat exchanger. The results show that apart from the τ_d effect, the perturbation parameters depend mainly on the cavity passing frequency f. At the thick plate solution, the combined passing frequency–delay time influences are significant only when the dimensionless frequency is smaller than 10. Within this range τ_d affects seriously not only the temperature perturbation amplitudes (which determine the thermal stresses) but also the heat fluxes and the accumulated energy ones. When f ≥ 10, the plate behaves as two separate semi-infinite slabs. Heat penetration delays greater than one cavity passing period may be possible.     

Rational Design and Synthesis of AT1R Antagonists

Hypertension is one of the most common diseases nowadays and is still the major cause of premature death despite of the continuous discovery of novel therapeutics. The discovery of the Renin Angiotensin System (RAS) unveiled a path to develop efficient drugs to fruitfully combat hypertension. Several compounds that prevent the Angiotensin II hormone from binding and activating the AT1R, named sartans, have been developed. Herein, we report a comprehensive review of the synthetic paths followed for the development of different sartans since the discovery of the first sartan, Losartan.     

ABC Triblock Copolymer Micelles: Spherical Versus Worm‐Like Micelles Depending on the Preparation Method

Well‐defined ABC triblock copolymers based on two hydrophilic blocks, A and C, and a hydrophobic block B are synthesized and their self‐assembly behavior is investigated. Interestingly, at the same solvent, concentration, pH, and temperature, different shape micelles are observed, spherical and worm‐like micelles, depending on the preparation method. Specifically, spherical micelles are observed with bulk rehydration while both spherical and worm‐like micelles are observed with film rehydration.