Zinc‐containing ionic liquid as a dual solvent‐catalyst in base‐free condensations under ultrasonic irradiation

In this study, natural‐based ionic liquid (IL) using caffeine (Caff), trietahnolamine (TEA) and ZnBr₂, [Caff‐TEA]⁺[ZnBr₃]^?, which features high catalytic activity and environmentally‐friendly nature was synthesized with melting point of 76 °C by a facile method. The synthesized [Caff‐TEA]⁺[ZnBr₃]^? has high catalytic activity as both of catalyst and solvent in condensation reactions for the synthesis of benzylidenes, bis‐hydroxyenones and xanthenes. Synthesized IL was characterized by proton nuclear magnetic resonance (¹HNMR), Fourier transform infrared spectroscopy (FT‐IR), X‐ray diffraction (XRD) and Energy‐dispersive X‐ray spectroscopy (EDX) analysis. Also synthesized heterocycles were characterized by FT‐IR, proton nuclear magnetic resonance (¹HNMR) and carbon nuclear magnetic resonance (¹³CNMR).     

Sulfonic acid-functionalized Fe3O4-supported magnetized graphene oxide quantum dots: A novel organic-inorganic nanocomposite as an efficient and recyclable nanocatalyst for the synthesis of dihydropyrano[2,3-c]pyrazole and 4H-chromene derivatives

In this research, the main emphasis has been focused on the preparation of a novel Fe₃O₄-supported propane-1-sulfonic acid-grafted graphene oxide quantum dots (Fe₃O₄@GOQD-O-(propane-1-sulfonic acid)) that it was readily synthesized via a five-step procedure as a hitherto unreported magnetic nanocatalyst. This newly prepared Fe₃O₄@GOQD-O-(propane-1-sulfonic acid) nanocomposite was structurally well-established by different analytical techniques including Fourier transform infrared (FT-IR), X-ray diffraction (XRD), energy-dispersive X-ray (EDX), thermal gravimetric analysis (TGA), field emission gun-scanning electron microscope (FESEM), high-resolution transmission electron microscopy (HRTEM) and vibrating sample magnetometer (VSM) analyses. The high catalytic performance of this nanocomposite was exhibited in one-pot synthesis of dihydropyrano[2,3-c]pyrazole and 4H-chromene derivatives under mild conditions. Low reaction times, excellent yields of the products, benignity of the catalyst, easy reaction work-up and magnetic recyclability of the catalyst are the main advantages of the present protocol. Also, our research indicated that the Fe₃O₄@GOQD-O-(propane-1-sulfonic acid) could be reused up to five times without considerable loss of catalytic activity.     

Copper-immobilized ionic liquid as an alternative to organic solvents in the one-pot synthesis of bioactive dihydropyrano[2,3-c]pyrazole derivatives

In this study, a novel Cu-immobilized ionic liquid (IL)was designed, characterized, and employed as both promoter and solvent in the synthesis of some dihydropyrano[2,3-c]pyrazoles. The synthesized ionic liquid was characterized by ¹H NMR, ¹³C NMR, FTIR, ICP and EDX analysis and showed high catalytic activity to proceed the synthesis of bioactive dihydropyrano[2,3-c]pyrazole derivatives. This method has the advantage of using the IL as a green medium for the synthesize of the products in high to excellent yields within short reaction times.     

Use of two-dimensional liquid fractionation for separation of proteins from cell lysates without the presence of methionine oxidation

A novel two-dimensional (2D) chromatographic method is developed to separate proteins from malignant breast cancer whole cell lysates. Protein mixtures are first separated according to their pIby chromatofocusing followed by an orthogonal non-porous reversed-phase separation. An important advantage of this 2D chromatographic method is that, unlike gel-based methods, it does not result in methionine oxidation. The lack of methionine oxidation during separation is demonstrated by the analysis of protein tryptic digests using matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) MS. Our novel 2D chromatographic method used in combination with on-target light-induced methionine oxidation provides a means for studying methionine-containing peptides. Methionine residues in peptide sequences are partially oxidized with light exposure. Neither the location nor the modification of methionine in the peptide sequence affects the oxidation. As a result, multiple peaks are observed in MALDI-TOF-MS spectra after light exposure. Sequence information derived from light-induced methionine can be applied to enhance the database search results obtained through peptide mass fingerprinting.     

The effect of an axial external magnetic field on the output power of a small-bore CuBr laser

In this work, the effect of an axial external moveable magnetic field on the output power of a CuBr laser with small-bore tube has been investigated. In all experiments, by applying an EMF along the tube axis, the laser output power has been decreased and by moving the EMF toward the cathode region, more substantial decrease of output power has been observed. The effect is more significant at a magnetic field intensity of 1100 G, Ne gas pressure of 35 Torr, frequency of 19 kHz and voltage of 3.8 kV, such that there was no laser emission when the EMF was placed around the cathode.     

Hindered coarsening of a phase-separating microemulsion due to dispersed colloidal particles

The addition of sterically stabilized colloidal particles to a phase-separating microemulsion leads to dramatic changes in its demixing behavior, especially during the later stages. Our microemulsion is composed of reverse micelles of sodium dodecyl sulfate, pentanol, and water in a dodecane continuous phase which separates into micelle-rich and micelle-poor phases above a lower critical solution temperature. The poly(methyl methacrylate) particles preferentially partition into the less structured, micelle-poor phase. Nucleation of the minority phase or spinodal decomposition close to criticality continue to occur in the presence of particles, albeit with pronounced pretransitional clustering of particles when the micelle-poor phase is in the minority. The coalescence of micelle-poor droplets and the coarsening of micelle-rich domains are both strongly modified due to the presence of colloidal particles. We use our observations of the early stages of phase separation to understand these late stage changes.     

Three hundred years of vibration engineering

Résumé Le problème des vibrations dans la technique moderne, particulièrement dans l'aviation, est un objet de recherches très approfondies auxquelles participent des savants et des ingénieurs de tous les pays. On croirait qu'il s'agit d'un phénomène découvert dans notre siècle, mais, une étude superficielle déjà, comme celle de l'auteur, démontre queGalilée fut le premier à étudier les oscillations d'un pendule simple et que grace a luiHuyghens, Hooke et quelques autres purent inventer des horloges et des montres de précision, munies de pendules soit linéaires soit à torsion. Les contributions deNewton vont davantage au fond de la question, particulièrement dans ses recherches sur la théorie des ondes. L'ère deBernoulli, Fourier etLagrange est discutée brièvement et sert d'introduction aux travaux de LordRayleigh, un des géants de l'acoustique. Les contributions des ingénieurs et physiciens des dernières soixante années sont mentionnées ainsi que des observations sur les phénomènes nonlinéaires. Pour conclure et pour démontrer que les problèmes vibratoires sont universels, l'article se termine par une citation d'un exemple de la physique atomique.      

An approximation of the analytical solution of the Jeffery-Hamel flow by decomposition method

Many researchers have been interested in application of mathematical methods to find analytical solutions of nonlinear equations and for this purpose, new methods have been developed. Since most of fluid mechanics problems due to boundary layer are strongly nonlinear, so analytical solution of them is confronted with some difficulty. In this Letter, the Jeffery-Hamel flow—a nonlinear equation of 3rd order—is studied by Adomian decomposition method. After introducing Adomian decomposition method and the way of obtaining Adomian's polynomial, we solved the problem for divergent and convergent channels. Finally, velocity distribution and shear stress constant is depicted at various Reynolds numbers and comparing our results with some earlier works illustrated their excellent accuracy.     

Studies in molecular structure,symmetry and conformation VI. Crystal and molecular structure of 1-aminocyclopentane carboxylic acid monohydrate

1-aminocyclopentane carboxylic acid monohydrate is monoclinic: space groupP2₁/c,a = 11·24,b = 6·27,c = 11·22 Å and = 97·6 °. The crystal structure was solved by the symbolic addition method and refined to anR factor of 12·1%. The cyclopentane ring is disordered; one of the carbon atoms exists in two alternative sites, leading to two possible conformations both of which are of the envelope type.The authors wish to thank Professor R. Srinivasan for valuable discussions and Professor G. N. Ramachandran for his keen interest. The full-matrix least-squares refinement program used was that of Gantzel, Sparks and Trueblood, modified for the CDC 3600 computer by Zalkin, Lundgren, Liminga and Braenden. The sigma 2 search program used was that of Dr. S. T. Rao. Thanks are due to these individuals for making available their programs. This work was supported in part by Grant NB-05306 to R. Zand from the National Institute of Neurological Diseases and Stroke, National Institute of Health.