全文获取类型
收费全文 | 327篇 |
免费 | 5篇 |
国内免费 | 2篇 |
专业分类
化学 | 233篇 |
晶体学 | 3篇 |
力学 | 10篇 |
数学 | 24篇 |
物理学 | 64篇 |
出版年
2023年 | 2篇 |
2022年 | 1篇 |
2021年 | 12篇 |
2020年 | 12篇 |
2019年 | 6篇 |
2018年 | 2篇 |
2017年 | 2篇 |
2016年 | 20篇 |
2015年 | 5篇 |
2014年 | 5篇 |
2013年 | 10篇 |
2012年 | 14篇 |
2011年 | 22篇 |
2010年 | 11篇 |
2009年 | 17篇 |
2008年 | 14篇 |
2007年 | 31篇 |
2006年 | 20篇 |
2005年 | 11篇 |
2004年 | 8篇 |
2003年 | 10篇 |
2002年 | 10篇 |
2001年 | 9篇 |
2000年 | 5篇 |
1999年 | 6篇 |
1998年 | 5篇 |
1997年 | 3篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 8篇 |
1993年 | 4篇 |
1992年 | 7篇 |
1991年 | 3篇 |
1990年 | 2篇 |
1989年 | 3篇 |
1988年 | 1篇 |
1986年 | 1篇 |
1985年 | 6篇 |
1984年 | 8篇 |
1983年 | 1篇 |
1978年 | 1篇 |
1977年 | 2篇 |
1976年 | 1篇 |
1975年 | 2篇 |
1974年 | 5篇 |
1973年 | 1篇 |
1948年 | 1篇 |
1903年 | 1篇 |
1902年 | 1篇 |
排序方式: 共有334条查询结果,搜索用时 31 毫秒
1.
2.
Enrica Bortolamiol Giacomo Isetta Isabella Caligiuri Dr. Nicola Demitri Prof. Dr. Stefano Paganelli Prof. Dr. Flavio Rizzolio Dr. Thomas Scattolin Prof. Dr. Fabiano Visentin 《欧洲无机化学杂志》2023,26(22):e202300084
A general synthetic entryway into novel cationic Pd(II) indenyl complexes bearing one alkyl/aryl phosphine and one N-heterocyclic carbene is reported. All metal complexes have been exhaustively characterized by spectroscopic and structural analyses, highlighting that the indenyl fragment has an hapticity intermediate between η3 and η5. Most of the target complexes are stable in solid state and in solution for a long time. Two different applications of these organopalladium compounds are proposed. Firstly, they have been tested as antiproliferative agents towards three different ovarian cancer cell lines, showing a cytotoxicity significantly higher than that of cisplatin, with a clear dependence on the nature of the coordinated phosphine. Moreover, the similar cytotoxicity towards cisplatin-sensitive and cisplatin-resistant cell lines suggests that these new palladium derivatives act with a different mechanism of action with respect to classical platinum-based drugs. Finally, the water-soluble palladium complexes bearing 1,3,5-triaza-7-phosphaadamantane (PTA) have demonstrated interesting catalytic performances in Suzuki–Miyaura coupling in aqueous media, being, inter alia, readily and efficiently recyclable. 相似文献
3.
4.
5.
6.
7.
The N, N′-dimethylformamide solvated crystal of the drug nitrofurantoin has been prepared and analysed by single-crystal X-ray diffraction. The two co-crystallized molecules, in the 1 : 1 stoichiometric ratio, are linked by a medium/strong N–H···O hydrogen bond (N···O is 2.759 (3) Å) and a weaker C–H···O interaction to form isolated supramolecular adducts, that in turn are packed into the lattice framework mainly through C–H···O hydrogen bonds. Two-dimensional fingerprint plots of Hirshfeld surfaces are used to visualize, analyze and compare intermolecular interactions found in the title compound and in similar structures. 相似文献
8.
9.
Marta Colombo Rosella Ferretti Leo Zanitti Roberto Cirilli 《Journal of separation science》2020,43(13):2589-2593
Ramosetron is an enantiopure active pharmaceutical ingredient marketed in Japan since 1996 and later in a few Southeast Asian countries predominantly as an antiemetic for patients receiving chemotherapy. In this study, a simple and rapid high‐performance liquid chromoatography method for the separation of ramosetron and its related enantiomeric impurity by using hydrophilic interaction liquid chromatography mode is presented. Chiral resolution was performed on an analytical column (100 mm × 4.6 mm id) packed with 3 μm particles of cellulose‐based Chiralpak IC‐3 chiral stationary phase. Using a mobile phase containing acetonitrile–water–diethylamine (100:10:0.1, v/v/v) and setting the column temperature at 35°C, the resolution value was 7.35. At a flow rate of 1 mL/min, the enantioseparation was completed within 5 min. The proposed method was partially validated and it has proven to be sensitive with limit of detection and limit of quantitation of the (S)‐enantiomer impurity of 44.5 and 133.6 ng/mL. 相似文献
10.
Rosella Ferretti Bruno GallinellaFrancesco La Torre Leo ZanittiLuciana Turchetto Antonina MoscaRoberto Cirilli 《Journal of chromatography. A》2009,1216(28):5385-5390
High-performance liquid chromatography (HPLC) enantioseparation of terazosin (TER) was accomplished on the immobilised-type Chiralpak IC chiral stationary phase (CSP) under both polar organic and reversed-phase modes. A simple analytical method was validated using a mixture of methanol–water–DEA 95:5:0.1 (v/v/v) as a mobile phase. Under reversed-phase conditions good linearities were obtained over the concentration range 8.76–26.28 μg mL−1 for both enantiomers. The limits of detection and quantification were 10 and 30 ng mL−1, respectively. The intra- and inter-day assay precision was less than 1.66% (RSD%). The optimised conditions also allowed to resolve chiral and achiral impurities from the enantiomers of TER. The proposed HPLC method supports pharmacological studies on the biological effects of the both forms of TER and analytical investigations of potential drug formulations based on a single enantiomer. At the semipreparative scale, 5.3 mg of racemic sample were resolved with elution times less than 12 min using a mobile phase consisting of methanol–DEA 100:0.1 (v/v) and both enantiomers were isolated with a purity of ≥99% enantiomeric excess (ee). The absolute configuration of TER enantiomers was assigned by comparison of the measured specific rotations with those reported in the literature. 相似文献