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1.
In this paper, we design a Branch and Bound algorithm based on interval arithmetic to address nonconvex robust optimization problems. This algorithm provides the exact global solution of such difficult problems arising in many real life applications. A code was developed in MatLab and was used to solve some robust nonconvex problems with few variables. This first numerical study shows the interest of this approach providing the global solution of such difficult robust nonconvex optimization problems.
相似文献2.
Buono Francesco De Santis Emilio Longobardi Maria Spizzichino Fabio 《Methodology and Computing in Applied Probability》2022,24(3):1987-2008
Methodology and Computing in Applied Probability - The family of the multivariate conditional hazard rate functions often reveals to be a convenient tool to describe the joint probability... 相似文献
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da Silva Andre Luis Ferreira Salas Ruben Andres Silva Emilio Carlos Nelli 《Meccanica》2021,56(2):417-437
Meccanica - Fiber reinforced materials are used in assorted engineering application and for this reason, new additive manufacturing technologies have been developed for this type of materials. With... 相似文献
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Mejía Hugo Fernando Giraldo Jiménez-Piqué Emilio Valdés Matías Procaccini Raúl Pellice Sergio 《Journal of Solid State Electrochemistry》2020,24(10):2451-2460
Journal of Solid State Electrochemistry - A novel material was developed using sol-gel chemistry and an environmental-friendly grafting process of clay nanoparticles. In a previous work of our... 相似文献
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Mireia Casasampere Eduardo Izquierdo Josefina Casas Jos Luís Abad Xiao Liu Ruijuan Xu Cungui Mao Young-Tae Chang Antonio Delgado Gemma Fabrias 《Chemical science》2020,11(48):13044
The use of intact cells in medical research offers a number of advantages over employing cell-free systems. In diagnostics, cells isolated from liquid biopsies can be directly used, speeding up the time of analysis and diminishing the risk of protein degradation by sample manipulation. In drug discovery, studies in live cells take into account aspects neglected in cell-free systems, such as uptake, metabolization, and subcellular concentration by compartmentalization of potential drug candidates. Therefore, probes for studies in cellulo are of paramount importance. Acid ceramidase (AC) is a lysosomal enzyme that hydrolyses ceramides into sphingoid bases and fatty acids. The essential role of this enzyme in the outburst and progress of several diseases, some of them still incurable, is well sustained. Despite the great clinical relevance of AC as a biomarker and therapeutic target, the specific monitoring of AC activity in live cells has remained elusive due to the concomitant existence of neutral and alkaline ceramidases. In this work, we report that 1-deoxydihydroceramides are exclusively hydrolysed by AC. Using N-octanoyl-18-azidodeoxysphinganine as a probe and a BODIPY-substituted bicyclononyne, we show the click-reliant predominant staining of lysosomes, with extra-lysosomal labeling also occurring in some cells. Importantly, using pharmacological and genetic tools together with high resolution mass spectrometry, we demonstrate that both lysosomal and extra-lysosomal staining are AC-dependent. These findings are translated into the specific flow cytometry monitoring of AC activity in intact cells, which fills an important gap in the field of diseases linked to altered AC activity.The use of intact cells in medical research offers a number of advantages over employing cell-free systems. 相似文献
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ABSTRACTA class of semilinear parabolic reaction diffusion equations with multiple time delays is considered. These time delays and corresponding weights are to be optimized such that the associated solution of the delay equation is the best approximation of a desired state function. The differentiability of the mapping is proved that associates the solution of the delay equation to the vector of weights and delays. Based on an adjoint calculus, first-order necessary optimality conditions are derived. Numerical test examples show the applicability of the concept of optimizing time delays. 相似文献
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Catalytic Asymmetric Reactions of 4‐Substituted Indoles with Nitroethene: A Direct Entry to Ergot Alkaloid Structures 下载免费PDF全文
Simone Romanini Emilio Galletti Dr. Lorenzo Caruana Prof. Andrea Mazzanti Prof. Fahmi Himo Dr. Stefano Santoro Prof. Mariafrancesca Fochi Prof. Luca Bernardi 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(49):17578-17582
A domino Friedel–Crafts/nitro‐Michael reaction between 4‐substituted indoles and nitroethene is presented. The reaction is catalyzed by BINOL‐derived phosphoric acid catalysts, and delivers the corresponding 3,4‐ring‐fused indoles with very good results in terms of yields and diastereo‐ and enantioselectivities. The tricyclic benzo[cd]indole products bear a nitro group at the right position to serve as precursors of ergot alkaloids, as demonstrated by the formal synthesis of 6,7‐secoagroclavine from one of the adducts. DFT calculations suggest that the outcome of the reaction stems from the preferential evolution of a key nitronic acid intermediate through a nucleophilic addition pathway, rather than to the expected “quenching” through protonation. 相似文献