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谢孟峡  徐晓云  王英典  刘媛 《化学学报》2005,63(22):2055-2062
应用紫外吸收光谱、荧光光谱和红外光谱等方法对人血清白蛋白(HSA)与4',5,7-三羟基二氢黄酮(naringenin,NAR)相互作用的机理进行了研究.紫外光谱显示,在生理pH下NAR分子中A环7位的酚羟基发生部分解离,7位酚羟基的解离使A环与B环上羰基形成的共轭体系的紫外吸收峰发生明显红移;药物与蛋白质的相互作用使该谱带发生了进一步的红移,说明该共轭体系参与了与蛋白质的相互作用.在药物与蛋白质浓度比(cNAR/cHSA)为0.1~10的范围内,NAR在HSA上只有一个结合位点(可能位于site I),结合常数为1.27×105L·mol~(-1)(n=5,RSD小于5%).研究了不同pH值条件下药物对蛋白质荧光猝灭的影响,发现药物分子中的没有解离的活性基团在结合过程中发挥着主导作用.在缓冲水溶液和重水溶液中分别测定了与药物作用前后蛋白质二级结构的变化.随着药物浓度的增加,NAR和HSA之间的相互作用使HSA的α-螺旋结构的含量明显降低,而β-折叠和β-转角结构的含量增加,无轨结构在药物浓度较高时也有少量的增加.结合紫外吸收光谱、荧光光谱和红外光谱结果,探讨了HSA与NAR相互作用的模式.  相似文献
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氮气氛中合成杂氮球烯,碳纳米管及纳米晶体的研究   总被引:1,自引:1,他引:0  
氮气氛中合成杂氮球烯、碳纳米管及纳米晶体的研究詹梦熊,余荣清,王育煌,杨士姚,程大典,刘朝阳,郑兰荪(厦门大学化学系,厦门,361005)关键词杂氮球烯,碳纳米管,纳米晶体,氮气氛自球烯及碳纳米管常规制备方法问世以来[1,2],制备方法的改进一直成为...  相似文献
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刘殿丽  刘颖 《分析化学》2006,34(4):554-556
建立了一种用电子捕获检测器气相色谱法(GC-ECD)测定大气及空气分离装置液空、液氧中N2O的测定方法。通过选择性条件试验,确定了用GC-ECD法测定大气及空气分离装置液空、液氧中N2O含量的最佳色谱柱为不锈钢填充柱,固定相为GDX-103(0.154~0.18 mm粒径);最佳载气流速为18 mL/m in,最佳分离的柱温为30℃。方法具有较高的灵敏度,检出限为:当进样量为0.5mL时,可测准至N2O浓度0.1μL/L的气体,检出限为0.014μL/L。方法的准确度较高,以峰面积定量,其标准偏差为0.013;相对标准偏差为3.74%。  相似文献
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The recurrence of acute gout attacks remains an unsolved problem in clinical therapy. In order to tackle this problem, poly(ε‐caprolactone) (PCL)/gelatin composite fibrous devices loaded with luteolin are presented via electrospinning for the therapy of gout and its recurrence. The luteolin‐loaded fibrous device has the capability of inhibiting metabolic activities and reducing inflammation‐associated cytokine productions (TNF‐a, IL‐1β, IL‐6) that are secreted by lipopolysaccharide stimulated RAW 264.7 macrophages. The device can also suppress the reaction activities of xanthine oxidase for 7 d in vitro. In vivo, acute gout model is established by injecting monosodium urate (MSU) crystals into New Zealand rabbits' knees, then the luteolin‐loaded PCL/gelatin (5:5) nanofiber device is implanted near the gout sites. The results show that the device can alleviate the acute gouty arthritis. In the mean time, the luteolin‐loaded PCL fiber device with a longer drug release profile is implanted in a recurrent gout model, which is constructed by injecting MSU crystals into rabbits' knees three times. The results on day 21 reveal that this device has the potential to overcome the recurrence of gout. Therefore, the drug‐loaded polymer fiber device can be an inspiration for potential gout therapy to overcome recurrent attacks.

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5.
We introduce the principle and applications of one‐photon absorption (OPA) and two‐photon absorption (TPA) controlled by external electric fields. The physical mechanism of OPA and TPA are firstly introduced, which can visually promote thoroughly understanding of principle and physical analysis. Secondly, the applications of different molecules in OPA and TPA with and without external electric field are introduced in detail. The effect of the external electric field on the charge transfer during the absorption process is also exemplified. Furthermore, the external electric field on the molecular orbital wave function is visualized through the charge transfer process in the excited state transitions. The purpose of this review is to deepen the understanding of the types of charge transfer under linear and non‐linear absorption in different systems.  相似文献
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Water‐soluble diblock copolymer, poly(N‐isopropylacrylamide)‐block‐poly(N‐vinyl‐2‐pyrroridone) (PNIPAMmb‐PNVPn), was found to associate with fullerene (C60), and thus C60 can be solubilized in water. The 63C60/PNIPAMmb‐PNVPn micelle formed a core‐shell micelle‐like aggregate comprising a C60/PNVP hydrophobic core and a thermoresponsive PNIPAM shell. The C60‐containing polymer micelle formation and its thermoresponsive behavior were characterized using light scattering and 1H NMR techniques. The hydrodynamic radius (Rh) of the C60‐bound polymer micelle increased with increasing temperature, which was ascribed to the hydrophobic association between dehydrated PNIPAM shells above lower critical solution temperature (LCST). 1H NMR data suggest that the motion of the PNIPAM block is restricted above LCST due to the dehydration of the PNIPAM shell in water. The generation of singlet oxygen by photosensitization by the C60‐bound polymer micelle was confirmed from photooxidation of 9,10‐anthracenedipropionic acid. Furthermore, DNA was found to be cleaved by visible light irradiation in the presence of the C60‐bound polymer micelle. Therefore, there may be a hope for a pharmaceutical application of the C60‐bound polymer micelle to cancer photodynamic therapy. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011.  相似文献
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