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High‐performance alternating current electroluminescent layers solution blended with mechanically and electrically robust nonradiating polymers 下载免费PDF全文
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This work investigates the problem of detecting gravitational wave (GW) events based on simulated damped sinusoid signals contaminated with white Gaussian noise. It is treated as a classification problem with one class for the interesting events. The proposed scheme consists of the following two successive steps: decomposing the data using a wavelet packet, representing the GW signal and noise using the derived decomposition coefficients; and determining the existence of any GW event using a convolutional neural network (CNN) with a logistic regression output layer. The characteristic of this work is its comprehensive investigations on CNN structure, detection window width, data resolution, wavelet packet decomposition and detection window overlap scheme. Extensive simulation experiments show excellent performances for reliable detection of signals with a range of GW model parameters and signal-to-noise ratios. While we use a simple waveform model in this study, we expect the method to be particularly valuable when the potential GW shapes are too complex to be characterized with a template bank. 相似文献
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Nithiyanandan Krishnan Devanathan Perumal Siriki Atchimnaidu Kaloor S. Harikrishnan Murali Golla Nilima Manoj Kumar Jemshiya Kalathil Jithu Krishna Dileep K. Vijayan Dr. Reji Varghese 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(5):1037-1041
High aspect ratio, sugar-decorated 2D nanosheets are ideal candidates for the capture and agglutination of bacteria. Herein, the design and synthesis of two carbohydrate-based Janus amphiphiles that spontaneously self-assemble into high aspect ratio 2D sheets are reported. The unique structural features of the sheets include the extremely high aspect ratio and dense display of galactose on the surface. These structural characteristics allow the sheet to act as a supramolecular 2D platform for the capture and agglutination of E. coli through specific multivalent noncovalent interactions, which significantly reduces the mobility of the bacteria and leads to the inhibition of their proliferation. Our results suggest that the design strategy demonstrated here can be applied as a general approach for the crafting of biomolecule-decorated 2D nanosheets, which can perform as 2D platforms for their interaction with specific targets. 相似文献
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Design and Development of a Non-Enzymatic Electrochemical Biosensor for the Detection of Glutathione
Shrute Kannappan Lakshmishri Prabakaran Noel Nesakumar K. Jayanth Babu Arockia Jayalatha Kulandaisamy Prof. John Bosco Balaguru Rayappan 《Electroanalysis》2023,35(1):e202100650
Glutathione (GSH-reduced form) is a tripeptide that plays a vital role as an antioxidant to remove xenobiotics in the human body and changes in GSH levels are a marker for the progression of various diseases. In this context, a highly sensitive non-enzymatic electrochemical biosensor for the detection of GSH has been developed using reduced graphene oxide Manganese oxide (rGMnO) nanocomposite as the nano-interface. Initially, graphene oxide was synthesized by Hummer's method and then thermally reduced in the presence of MnO2 in a blast furnace to obtain rGMnO nanocomposite. The nanocomposite was characterized to validate its structure and morphological properties via Scanning electron microscopy (SEM), X-ray diffraction (XRD), Raman, and X-ray photoelectron spectroscopy (XPS). Cyclic voltammetry and amperometry studies showed that upon the addition of GSH, the Pt/rGMnO modified working electrode exhibited a linear response in the range of 1–100 μM at an input voltage of −0.62 V. The developed sensor was found to have a sensitivity of 0.3256 μA μM−1 and LOD of 970 nM with a recovery of 92–104 % in real blood serum samples. 相似文献
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Design and Synthesis of High‐Affinity Dimeric Inhibitors Targeting the Interactions between Gephyrin and Inhibitory Neurotransmitter Receptors 下载免费PDF全文
Dr. Hans Michael Maric Vikram Babu Kasaragod Dr. Linda Haugaard‐Kedström Dr. Torben Johann Hausrat Prof. Dr. Matthias Kneussel Prof. Dr. Hermann Schindelin Prof. Dr. Kristian Strømgaard 《Angewandte Chemie (International ed. in English)》2015,54(2):490-494
Gephyrin is the central scaffolding protein for inhibitory neurotransmitter receptors in the brain. Here we describe the development of dimeric peptides that inhibit the interaction between gephyrin and these receptors, a process which is fundamental to numerous synaptic functions and diseases of the brain. We first identified receptor‐derived minimal gephyrin‐binding peptides that displayed exclusive binding towards native gephyrin from brain lysates. We then designed and synthesized a series of dimeric ligands, which led to a remarkable 1220‐fold enhancement of the gephyrin affinity (KD=6.8 nM ). In X‐ray crystal structures we visualized the simultaneous dimer‐to‐dimer binding in atomic detail, revealing compound‐specific binding modes. Thus, we defined the molecular basis of the affinity‐enhancing effect of multivalent gephyrin inhibitors and provide conceptually novel compounds with therapeutic potential, which will allow further elucidation of the gephyrin–receptor interplay. 相似文献
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First Stereoselective Synthesis of the Cytotoxic Polyketide (4R)‐1‐(3,5‐Dihydroxyphenyl)‐4‐hydroxypentan‐2‐one 下载免费PDF全文
Kothakonda Rajendra Prasad Sudina Purushotham Reddy Katragadda Suresh Babu Janaswamy Madhusudana Rao 《Helvetica chimica acta》2015,98(1):143-147
The first stereoselective synthesis of the cytotoxic polyketide (4R)‐1‐(3,5‐dihydroxyphenyl)‐4‐hydroxypentan‐2‐one ( 1 ) was achieved from readily available propylene oxide and 3,5‐dimethoxybenzyl alcohol. The synthesis involves Jacobsen's hydrolytic kinetic resolution (HKR) and Grignard reaction as key steps. 相似文献
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Juan de Torres Petru Ghenuche Satish Babu Moparthi Victor Grigoriev Jérôme Wenger 《Chemphyschem》2015,16(4):782-788
Zero‐mode waveguides (ZMWs) can confine light into attoliter volumes, which enables single molecule fluorescence experiments at physiological micromolar concentrations. Of the fluorescence spectroscopy techniques that can be enhanced by ZMWs, Förster resonance energy transfer (FRET) is one of the most widely used in life sciences. Combining zero‐mode waveguides with FRET provides new opportunities to investigate biochemical structures or follow interaction dynamics at micromolar concentrations with single‐molecule resolution. However, prior to any quantitative FRET analysis on biological samples, it is crucial to establish first the influence of the ZMW on the FRET process. Here, we quantify the FRET rates and efficiencies between individual donor–acceptor fluorophore pairs that diffuse into aluminum zero‐mode waveguides. Aluminum ZMWs are important structures thanks to their commercial availability and the large amount of literature that describe their use for single‐molecule fluorescence spectroscopy. We also compared the results between ZMWs milled in gold and aluminum, and found that although gold has a stronger influence on the decay rates, the lower losses of aluminum in the green spectral region provide larger fluorescence brightness enhancement factors. For both aluminum and gold ZMWs, we observed that the FRET rate scales linearly with the isolated donor decay rate and the local density of optical states. Detailed information about FRET in ZMWs unlocks their application as new devices for enhanced single‐molecule FRET at physiological concentrations. 相似文献