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This paper reports the results of gossypol effects on the testicular mitochondrial ultrastructures and functions. A hypothesis of mechanism of gossypol action based on our experimental data was postulated.Electron microscopic observations confirmed further our previous studies that the mitoehondria of the target germ cells were the most sensitive and the most severely damaged among cellular organelles in response to gossypol. The damages included the swelling, vacuolation, crista depletion, lysis, granular accumulation in matrix and the process of intact mitochondria disintegration. The activity of the mitochondrial marker enzyme, the LDH-X of human spermatozoa, was markedly decreased or suppressed completely after gossypol treatment.The functions of isolated testieular mitochondria determined by Warburg manometric and oxygen electrode polarographic methods indicated that gossypol stimulated respiration but inhibited slightly the oxidative phosphorylation at low concentrations (20-40μM) in vitro. With  相似文献   
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本文报道棉酚对睾丸线粒体功能及超微结构的影响,并根据实验结果提出棉酚作用机理假说。 电镜观察证明生精细胞线粒体是对棉酚最敏感和损伤最严重的细胞器,呈现由肿胀、空泡化、嵴突缺损、溶解,到整体崩解等损伤过程。精子线粒体特异的乳酸脱氢酶同功酶(LDH-X)在服棉酚后明显受到抑制。 用Warburg呼吸器和Clark氧电极测定结果表明棉酚到达一定浓度后可完全抑制离体睾丸线粒体的呼吸(300μM)和氧化磷酸化(80μM)过程,其解偶联作用与剂量大小成正相关。大鼠口服棉酚后分离的睾丸线粒体的P/O值亦同样呈现非常明显的降减。 ~(14)C-棉酚对精子线粒体有较高亲和性,其分布量较其他亚细胞组分高2—3倍.与~(3)H-哇巴因一起示踪定位亦得到类似的结果。 对棉酚的亚细胞作用位点及其中断精子发生的分子作用机理以及不同细胞类型对棉酚的敏感性等问题进行了分析和讨论。  相似文献   
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