Effect of astrocyte on synchronization of thermosensitive neuron-astrocyte minimum system

Astrocytes have a regulatory function on the central nervous system (CNS), especially in the temperature-sensitive hippocampal region. In order to explore the thermosensitive dynamic mechanism of astrocytes in the CNS, we establish a neuron-astrocyte minimum system to analyze the synchronization change characteristics based on the Hodgkin-Huxley model, in which a pyramidal cell and an interneuron are connected by an astrocyte. The temperature range is set as 0 ℃-40 ℃ to juggle between theoretical calculation and the reality of a brain environment. It is shown that the synchronization of thermosensitive neurons exhibits nonlinear behavior with changes in astrocyte parameters. At a temperature range of 0 ℃-18 ℃, the effects of the astrocyte can provide a tremendous influence on neurons in synchronization. We find the existence of a value for inositol triphosphate (IP₃) production rate and feedback intensities of astrocytes to neurons, which can ensure the weak synchronization of two neurons. In addition, it is revealed that the regulation of astrocytes to pyramidal cells is more sensitive than that to interneurons. Finally, it is shown that the synchronization and phase transition of neurons depend on the change in Ca²⁺ concentration at the temperature of weak synchronization. The results in this paper provide some enlightenment on the mechanism of cognitive dysfunction and neurological disorders with astrocytes.     

Delannoy数与Schröder数的一些和式公式

研究了Delannoy数与Schr?der数.利用分析方法和组合技巧,建立了任意多个Delannoy数乘积的一些和式公式,并对Schroder数的和式公式进行了类似的研究.     

基于DNA酶催化的卟啉金属化检测锌

利用G-四链体DNA（T30695）催化Zn²⁺插入到中卟啉IX（MPIX）中，引起荧光偏移的特点，建立了检测Zn²⁺的方法。在40μmol/L MPIX、0.6μmol/L Pb²⁺、5μmol/L T30695和1%Triton的最优实验条件下，该方法在Zn²⁺浓度为0.5～5μmol/L范围内呈现良好的线性关系，相关系数R²=0.95，检出限为73.5 nmol/L。离子选择性实验表明该方法对Zn²⁺具有较好的选择性，用于实际样品测定，回收率在94.7%～100.4%之间。     

Identification of Residue Involved in Nucleotidyltransferase Activity of LinA from Staphylococci by Site-directed Mutagenesis

The lincosamide class of antibacterials is widely used for the treatment of a broad spectrum of infections, and one prevalent route of resistance to lincosamides in pathogenic gram-positive cocco is antibiotic modification. Enzymes encoded by lin genes, belonging to nucleotidyltransferase superfamily, catalyze adenylylation to inactivate lincosamides. LinA can adenylylate lincosamides at either 3?-or 4?-OH of the methylthiolincosamide sugar. The crystal structure of LinA/lincomycin has confirmed its active site. However, the residue interacting with nucleotidyl donors remains elusive. Here, we modeled the complex structure of LinA/lincomycin/Mg~(2+)/AMPCPP to reveal a putative pocket for nucleotidyl donors and suggested the residue R45 in this pocket involved in the recognition of donor substrates NTP and catalysis. ITC and enzyme activity assays show that the mutation of residue R45 impairs LinA nucleotidyltransferase activity in vitro. This work provides insights into the molecular mechanism of the nucleotide binding and transferring activity of antibiotic NTases.     

基于有限元-时域分段自适应算法的围岩衬砌耦合渐进分析

以开挖时间、一衬时间、二衬时间划分时间区段，考虑围岩与衬砌为弹性/粘弹性介质，将围岩的“位移/应力释放不完全”、开挖等影响模拟为载荷的渐进释放，提出一个有限元-时域分段自适应算法，求解围岩衬砌耦合问题，并通过数值算例对算法进行了验证。所提方法给出了各时间区段的关联条件；可更准确描述各变量随时间的变化；同时将原时空耦合问题转化为一系列空间问题，并利用有限元方法递推求解；当步长变化时可通过自适应计算保证稳定的计算精度。此外，还建立了一个载荷渐进参数的反问题数值求解模型，并给出了相关算例。     

基于近似解析法的超导储能磁体设计

降低超导储能磁体的研制成本一直是控制超导磁储能系统(Superconducting Magnetic Energy Storage, SMES) 总成本的重要手段之一. 本文考虑在一定磁体结构参数范围内, 磁体产生的最大磁场值可以采用级数进行 表示, 磁体的电感值可以采用线性函数表示, 给出了超导储能磁体磁场能量的近似解析表达式, 提出了一种基于近 似解析法的超导储能磁体设计方法. 该方法以储能磁体的线材用量最小作为设计目标, 在给定超导线材参数和临界电流特性曲线, 以及磁体储能总量要求的情况下, 依据此方法可快速的得到成本最优时所对应的磁体结构参数.将近似解析法优化和采用传统的有限元软件 Ansys 仿真优化进行对比分析, 结果表明采用近似解析法进行磁体优化更加方便快捷, 节省了大量计算时间.     

关于一道反常积分习题的探讨

对华东师范大学数学系编写的数学分析教材以及陈纪修等编写的数学分析教材课后一道反常积分习题给出反例,并通过增加条件,得到正确结论.     

等离子体激励器的静特性与高速特性仿真研究

A parametric study of high-frequency plasma jet actuator was carried out, using the experiment- tally measured energy distribution law of arc discharge as an ideal heat source. The influence of the exit angle of the actuator on the flow field was explored. The jet flow field characteristics of the spark discharge actuator under supersonic flow (Ma0=2.0) were investigated. The results show that the energy density of heat flux increases and the jet front and forward shock wave moves faster with the decrease of discharge region, and the smaller the exit angle of the jet is, the stronger the momentum injection ability of the actuator along the flow direction is. The rule still applies under high-speed air flow conditions. Compared to the static condition, the momentum injection capability of the jet is stronger and the influence domain is larger under supersonic flow conditions.