DETECTION OF DNA-PSORALEN PHOTOADDUCTS in situ

Abstract— An immunological method, with the use of specific immune serum, has been developed for detection of 8-methoxypsoralen (8-MOP) photoadducts to DNA, formed in situ in cell nuclei, after combined treatment with 8MOP and UV-A irradiation (Zarçbska et al. , 1978). Lymphocytes fixed on slides or in suspension, and cryostat sections of different mammalian tissues, served as antigenic substrate, after treatment with 8-MOP and UV-A in vitro. Specific fluorescence in these substrates was detected in the nuclei after treatment with 30 ˜ 140 kJ/m² UV-A in the presence of 0.1-0.3 μg/cm² 8-MOP. PHA-stimulated-lymphocytes appeared to be the most sensitive substrate.
However, hairless mice treated with high doses of UV-A in vivo , 70 ˜ 360 kJ/m² did not reveal a specific fluorescence of epidermal nuclei, unless a high local concentration of 8-MOP was attained.
The apparent discrepancy in the level of photoadduct detection between the in vitro and in vivo treated specimens was explained by the low number of DNA-8-MOP-photoadducts formed in vivo under these experimental conditions. The relevance of these findings to the role of DNA-8-MOP-photoadducts formed during PUVA photochemotherapy is discussed.     

Deformed Bosons: Combinatorics of Normal Ordering

We solve the normal ordering problem for (A A) ⁿ where A and A are one mode deformed ([A,A ] = [N+1] – [N]) bosonic ladder operators. The solution generalizes results known for canonical bosons. It involves combinatorial polynomials in the number operator N for which the generating function and explicit expressions are found. Simple deformations provide examples of the method.     

The Boson Normal Ordering Problem and Generalized Bell Numbers

For any function F(x) having a Taylor expansion we solve the boson normal ordering problem for $F [(a^\dag)^r a^s]$, with r, s positive integers, $F [(a, a^\dag]=1$, i.e., we provide exact and explicit expressions for its normal form $\mathcal{N} \{F [(a^\dag)^r a^s]\} = F [(a^\dag)^r a^s]$, where in $ \mathcal{N} (F) $ all a's are to the right. The solution involves integer sequences of numbers which, for $ r, s \geq 1 $, are generalizations of the conventional Bell and Stirling numbers whose values they assume for $ r=s=1 $. A complete theory of such generalized combinatorial numbers is given including closed-form expressions (extended Dobinski-type formulas), recursion relations and generating functions. These last are special expectation values in boson coherent states.AMS Subject Classification: 81R05, 81R15, 81R30, 47N50.     

Combinatorial solutions to normal ordering of bosons

We present a combinatorial method of constructing solutions to the normal ordering of boson operators. Generalizations of standard combinatorial notions — the Stirling and Bell numbers, Bell polynomials and Dobinski relations — lead to calculational tools, which allow to find explicitly normally ordered forms for a large class of operator functions. Presented at the International Colloquium “Integrable Systems and Quantum Symmetries”, Prague, 16–18 June 2005.     

Dobiński relations and ordering of boson operators

We introduce a generalization of the Dobiński relation, through which we define a family of Bell-type numbers and polynomials. Such generalized Dobiński relations are coherent state matrix elements of expressions involving boson ladder operators. This may be used in order to obtain normally ordered forms of polynomials in creation and annihilation operators, both if the latter satisfy canonical and deformed commutation relations.     

ON QUOTIENTS OF BRAID GROUPS

ABSTRACT.

Let G be the group ?[t, t ^?1] x ?. By studying the action of the braid group B_n on the set Gⁿ , we obtain representations of B_n into a wreath product of the symmetric group and the general linear group over ?[t, t ^?1]. This in particular recovers the Burau representation of the braid group. Furthermore, some quotients of the braid group are obtained by using the representations found.     

Epitaxial Nd-doped α-(Al(1-x)Ga(x))2O3 films on sapphire for solid-state waveguide lasers

Single-crystal aluminum-gallium oxide films have been grown by molecular beam epitaxy in the corundum phase. Films of the (Al(1-x)Ga(x))(2)O(3) alloys doped with neodymium have favorable properties for solid-state waveguide lasers, including a high-thermal-conductivity sapphire substrate and a dominant emission peak in the 1090-1096 nm wavelength range. The peak position is linearly correlated to the unit cell volume, which is dependent on film composition and stress. Varying the Ga-Al alloy composition during growth will enable the fabrication of graded-index layers for tunable lasing wavelengths and low scattering losses at the interfaces.     

Energetics for the new forms of carbon-clusters

The growth of closedC _n -structures like fullerenes, shelled fullerenes, tubules and capped tubules controlled by the interplay of surface- and bending-energy is studied. Tubules are less stable than corresponding fullerenessC _n , and these are forn>n _c less stable than shelled fullerenes. Growth of fullerenes from graphite sheets requires bond breaking and bond rearrangement to form pentagons and finite temperatures to overcome energy barriers. Thermodynamical arguments are used to discuss the temperature- and size-dependence of the formation of the new forms of carbon. We argue that trapping of foreign atoms or molecules inside the closed structure may be achieved most efficiently by mixing these with carbon clusters before caging occurs.