Determination of bencyclane in human plasma by means of capillary gas chromatography and nitrogen-phosphorus selective detection

A sensitive and specific method for the determination of bencyclane in human plasma is presented. Bencyclane was extracted from human plasma with two 3-ml volumes of isooctane and was shaken for 10 min. The organic phase was separated and evaporated to dryness at 40 degrees C under a nitrogen stream. The residue was dissolved and an aliquot was injected into the gas chromatograph. The separation was performed with a DB-17 column with helium as the carrier gas. Nitrogen-selective detection was performed. The quantification was performed with the signal output. The limit of detection was 1 ng/ml.     

Über die Darstellung von Di(i-propyl)thiosulfonium-Salzen

On the Preparation of Di(i-propyl)thiosulfonium Salts [1] The preparation of the mercaptosulfonium salts (i-C₃H₇)₂SSX⁺SbCl₆^? (X = H, D) and of the chlorothiosulfonium salts (i-C₃H₇)₂SSCl⁺MF₆^? (M = As, Sb) and (i-C₃H₇)₂SSSCl⁺SbCl₆^? is reported. They are formed by reaction of chlorinated or protonated (i-C₃H₇)₂S with excess H₂S or SCl₂ and S₂Cl₂. The thiosulfonium compounds are characterized by vibrational and NMR spectroscopic methods.     

Direktsynthese von orthometallierten Ketonen des Typs RCO (o-C6H4)Mn(CO)4−nLn (R = Alkyl- und Arylrest,n = 0, 1, 2, L = Ligand)

Direct Synthesis of Orthometallated Ketones of the Type RCO(o-C₆H₄)Mn(CO)_4?nL_n (R = Alkyl and Aryl Groups, n = 0, 1, 2, L = Ligand) The starting materials of the type RMn(CO)_5?nL_n und (C₆H₅)₂ Hg react to the products of the type RCO(o-C₆H₄)Mn(CO)_4?nL_n[n = 0, R = Ch₃, C₂H₅, C₃H₇, C₆H₅,CH₂; R = C₆H₅, n = 1, L = E(C₆H₅)₃, E = P, As, Sb; R = C₆H₅, n = 2, L = P(OR′)₃, R′ = C₆H₅, CH₃, C₂H₅, C₃H₇]. Steps of their complex reaction pathway are proposed. These orthometallated substances have been characterized by means of ¹H-n.m.r., i.r. and u.v. spectroscopic measurements. The determination of the molecular structure of the two compounds RCO(o-C₆H₄)Mn(CO)₃L [R = C₂H₅, L = CO; R = C₆H₅, L = As(C₆H₅)₃] show that both contain a planar heterocyclic five-membered ring of the type .     

A Novel Anti-Inflammatory d-Peptide Inhibits Disease Phenotype Progression in an ALS Mouse Model

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterised by selective neuronal death in the brain stem and spinal cord. The cause is unknown, but an increasing amount of evidence has firmly certified that neuroinflammation plays a key role in ALS pathogenesis. Neuroinflammation is a pathological hallmark of several neurodegenerative disorders and has been implicated as driver of disease progression. Here, we describe a treatment study demonstrating the therapeutic potential of a tandem version of the well-known all-d-peptide RD2 (RD2RD2) in a transgenic mouse model of ALS (SOD1*G93A). Mice were treated intraperitoneally for four weeks with RD2RD2 vs. placebo. SOD1*G93A mice were tested longitudinally during treatment in various behavioural and motor coordination tests. Brain and spinal cord samples were investigated immunohistochemically for gliosis and neurodegeneration. RD2RD2 treatment in SOD1*G93A mice resulted not only in a reduction of activated astrocytes and microglia in both the brain stem and lumbar spinal cord, but also in a rescue of neurons in the motor cortex. RD2RD2 treatment was able to slow progression of the disease phenotype, especially the motor deficits, to an extent that during the four weeks treatment duration, no significant progression was observed in any of the motor experiments. Based on the presented results, we conclude that RD2RD2 is a potential therapeutic candidate against ALS.     

Eine Meßapparatur zur Untersuchung des Kriech- und Relaxationsverhaltens von Polymeren unter Torsion

Zusammenfassung Zur experimentellen Bestimmung der Kriechfunktion J(t) und der Relaxationsfunktion G(t) unter Torsionsbelastung der Probe wurde eine Meßapparatur entwickelt. Das mechanisch-elektrische Meßprinzip sowie eine Prozeßrechnerkopplung gestatten einen weitgehend automatischen Meßbetrieb. Änderungen an den physikalischen Versuchsbedingungen können rein Software-seitig durchgeführt werden.Das entsprechende Auswerteprogramm liefert neben numerischen Werten eine Zeichnung der entsprechenden Masterkurven, die mit Hilfe der WLF-Gleichung konstruiert werden.Messungen an kommerziellem PMMA zeigen einen Meßz bereich fürJ(t) von 10^–9 bis 10^–5 m²/N und für G(t) von 10° bis N 10⁵ N/m² ; das zugängliche Temperaturintervall liegt zwischen –180 °C und 200 °C. Damit ist der für die meisten Polymere erforderliche Bereich erfaßt.Mit 9 Abbildungenjetzt: KFA Jülich GmbH, Institut für Festkörperforschung (IFF).     

Inclusive production of non-strange resonances inK − p interactions at 32 GeV/c

New data on the inclusive production of the non-strange resonances ?⁰(770), ω(783), ?(1020) andf(1270) inK ^? p interactions at 32 GeV/c are presented. The inclusive production cross sections are equal to (4.32±0.72) mb, (3.7±1.4) mb, (0.65±0.10) mb and (0.91±0.35) mb respectively. Estimates of the topological cross sections are also obtained. The invariant and non-invariantx-distributions for the vector mesons ?⁰ and ? indicate the prevalence of forward resonance production in the c.m. system. For the tensorf-meson the rapidity andx-distributions are presented. Thet′-distributions for ?⁰, ?, andf have exponential slopes of 0.6±0.1 GeV^?2, 1.2±0.2 GeV^?2, and 0.8±0.5 GeV^?2 respectively. The exponential slope ofp _T ² -distribution of thef-meson is equal to (2.3±0.5) GeV^?2.     

Holography through fog. A new version

Seeing through fog is better with holography than with ordinary photography or human vision. This has to do with the Doppler effect, which is imparted on the light that is scattered by moving fog droplets. Experiments of this type are known since about ten years. So far, these experiments were always performed with off-axis holography, while we now propose to use on-axis holography. The new approach is better matched to the capabilities of the electronic components that are needed for hologram reconstruction in real-time. Advantages in resolution and dynamic range are predicted and verified experimentally.