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Denis Kudryavtsev Anastasia Isaeva Daria Barkova Ekaterina Spirova Renata Mukhutdinova Igor Kasheverov Victor Tsetlin 《Molecules (Basel, Switzerland)》2021,26(5)
Slow-channel congenital myasthenic syndromes (SCCMSs) are rare genetic diseases caused by mutations in muscle nicotinic acetylcholine receptor (nAChR) subunits. Most of the known SCCMS-associated mutations localize at the transmembrane region near the ion pore. Only two SCCMS point mutations are at the extracellular domains near the acetylcholine binding site, α1(G153S) being one of them. In this work, a combination of molecular dynamics, targeted mutagenesis, fluorescent Ca2+ imaging and patch-clamp electrophysiology has been applied to G153S mutant muscle nAChR to investigate the role of hydrogen bonds formed by Ser 153 with C-loop residues near the acetylcholine-binding site. Introduction of L199T mutation to the C-loop in the vicinity of Ser 153 changed hydrogen bonds distribution, decreased acetylcholine potency (EC50 2607 vs. 146 nM) of the double mutant and decay kinetics of acetylcholine-evoked cytoplasmic Ca2+ rise (τ 14.2 ± 0.3 vs. 34.0 ± 0.4 s). These results shed light on molecular mechanisms of nAChR activation-desensitization and on the involvement of such mechanisms in channelopathy genesis. 相似文献
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V. Ya. Popkova L. E. Vinogradova L. A. Leites V. K. Osmanov 《Russian Chemical Bulletin》1991,40(10):2075-2078
The reaction of ammonia with 2-chloroperfluoro-1-cyclohexene-1-thiocyanate leads to 2-amino-7-iminoperfluoro-4,5,6-trihydrobenzo-1,3-thiazole (II) due to intramolecular heterocyclization in the Thorpe reaction with the concurrent exoiminization. Analysis of the IR spectra of (II) in CCl4 and in the solid phase indicated that molecules of (II) in the crystal form hydrogen-bonded centrosymmetric dimers (D), which are in equilibrium with free molecules of (II) in solution.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 10, pp. 2366–2370, October, 1991.The authors express their gratitude to D. I. Zagorevskii for taking the mass spectrum of (II) and to L. S. German for a useful discussion of this work. 相似文献
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In this paper experimental study and mathematical modelling of newly designed vibro-impact moling rig are presented. The design is based on electro-mechanical interactions of a conductor with an oscillating magnetic field. The rig consists of a metal bar placed within a solenoid which is connected to an RLC circuit, and an obstacle block positioned nearby. Both the solenoid and the block are attached to a base board. Externally supplied alternating voltage causes the bar to oscillate and hit the block resulting in the forward motion of the base board mimicking a mole penetration through the soil. By varying the excitation voltage and the capacitance in the circuit, a variety of system responses can be obtained.In the paper the rig design and experimental procedure are explained in detail, and the mathematical modelling of the rig is described. Then the obtained coupled electro-mechanical equations of motion are integrated numerically, and a comparison between experimental results and numerical predictions is presented. 相似文献
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Methods of preparing diverse metallosupramolecular polymers containing 2,2′-bipyridine and 2,2′:6′,2″-terpyridine moieties in main chains and their properties have been considered and analyzed. It has been shown that these polymers offer new possibilities for the design of materials possessing valuable specific characteristics. 相似文献
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T. P. Pogrebnaya V. G. Solomonik V. N. Vinogradova M. I. Godneva 《Theoretical and Experimental Chemistry》1987,22(6):693-697
The geometric structure, force fields, and vibrational spectra of M2O and MOH (M=Li, Na) molecules have been investigated. The size of the d basis on the oxygen atom has a significant influence only on the frequency of the deformation vibration 3. Experimentally unknown constants of the molecules considered have been evaluated.Translated from Teoreticheskaya i Éksperimental'naya Khimiya, Vol. 22, No. 6, pp. 724–728, November–December, 1986. 相似文献
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I. B. Rabinovich N. V. Karyakin É. S. Dzharimova S. A. Siling I. I. Ponomarev S. V. Vinogradova 《Russian Chemical Bulletin》1984,33(4):716-723
Conclusions The reaction of phthalonitrile condensation with m-phenylenediamine is thermodynamically allowed at temperatures from 250° to 500°K, and its equilibrium is almost completely shifted toward the formation of the macroheterocycle.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 4, pp. 779–787, April, 1984. 相似文献