Hybrid (ND-Co3O4/EG) nanoliquid through a permeable cylinder under homogeneous-heterogeneous reactions and slip effects

Journal of Thermal Analysis and Calorimetry - Modeling and computations are performed to study the ND-Co3O4/EG hybrid nanoliquid mixed convective flow past a vertical porous cylinder. The flow...     

A dried blood spot assay with HPLC–MS/MS for the determination of larotrectinib in mouse blood and its application to a pharmacokinetic study

Larotrectinib is a first-generation tropomyosin kinase inhibitor, approved for the treatment of solid tumors. In this paper, we present a validated dried blood spot (DBS) method for the quantitation of larotrectinib from mouse blood using HPLC–MS/MS, which was operated under multiple reaction monitoring mode. To the DBS disc cards, acidified methanol enriched with internal standard (IS; enasidenib) was added and extracted using tert-butyl methyl ether as an extraction solvent with sonication. Chromatographic separation of larotrectinib and the IS was achieved on an Atlantis dC₁₈ column using 10 mm ammonium formate–acetonitrile (30:70, v/v) delivered at a flow-rate of 0.80 ml/min. Under these optimized conditions, the retention times of larotrectinib and the IS were ~0.93 and 1.37 min, respectively. The total run time was 2.50 min. Larotrectinib and the IS were analyzed using positive ion scan mode and parent–daughter mass to charge ion (m/z) transitions of 429.1 → 342.1 and 474.1 → 267.1, respectively, were used for the quantitation. The calibration range was 1.06–5,080 ng/ml. No matrix effect or carryover was observed. Hematocrit did not influence DBS larotrectinib concentrations. All of the validation parameters met the acceptance criteria. The applicability of the validated method was shown in a mouse pharmacokinetic study.     

Ferromagnetism at 300 K in spin-coated films of Co doped anatase and rutile-TiO2

Thin films of Ti_1−xCo_xO₂ (x=0 and 0.03) have been prepared on sapphire substrates by spin-on technique starting from metalorganic precursors. When heat treated in air at 550 and 700 °C, respectively, these films present pure anatase and rutile structures as shown both by X-ray diffraction and Raman spectroscopy. Optical absorption indicate a high degree of transparency in the visible region. Such films show a very small magnetic moment at 300 K. However, when the anatase and the rutile films are annealed in a vacuum of 1×10⁻⁵ Torr at 500 and 600 °C, respectively, the magnetic moment, at 300 K, is strongly enhanced reaching 0.36μ_B/Co for the anatase sample and 0.68μ_B/Co for the rutile one. The ferromagnetic Curie temperature of these samples is above 350 K.     

Quest for inosito-inositols: synthesis of novel, annulated and conformationally locked inositols

A new family of annulated inositols (inosito-inositols) has been conceptualized. Naphthalene has been elaborated into novel cyclohexa-annulated neo- and chiro-inositols, with two additional hydroxyl functionalities, through a series of stereoselective oxyfunctionalization protocols. The trans-ring fusion present in these new annulated inositols ensures conformational locking.     

Contact hypersurfaces of Kaehler manifolds

Contact hypersurfaces of a Kaehler manifold have been characterized and classified, assuming the second fundamental form to be Codazzi (in particular, parallel). We have also discussed the special cases when the ambient space is a (i) Calabi-Yau manifold and (ii) a complex space-form.     

PIV studies of large scale structures in the near field of small aspect ratio elliptic Jets

The near flow field of small aspect ratio elliptic turbulent free jets (issuing from nozzle and orifice) was experimentally studied using a 2D PIV Two point velocity correla tions in these jets revealed the extent and orientation of the large scale structures in th e major and minor planes. The spatial filtering of the instantaneous velocity field using Gaussian convolution kernel shows that while a single large vortex ring circumscribing the jet seems to be present at the exit of nozzle, the orifice jet exhibited a number of smaller vortex ring pairs close to jet exit. The smaller length scale observed in the case of the orifice jet is rep resentative of the smaller azimuthal vor tex rings that generate axial vortex field as they are convected. This results in the axis-switching in th e case of orifice jet and may have a mechanism differ ent from the self induction process as observed in the case of contoured nozzle jet flow.     

Polyazamacrocycles VI. Homo-trimetallic copper(II) and nickel(II) complexes with a new tri-cavity macrocycle

Summary A new tri-cavity decaaza macrocycle (TCM) has been synthesised by the condensation of tetra(aminopropyl)-cyclam with diethanolamine. The new macrocyclic ligand forms tri-nuclear complexes, [Cu₃(TCM)(H₂O)₂]-(ClO₄)₆ and [Ni₃(TCM)(H₂O)₂](ClO₄)₆.     

Nitric oxide concentration measurements in atmospheric pressure flames using electronic-resonance-enhanced coherent anti-Stokes Raman scattering

We report the application of electronic-resonance-enhanced coherent anti-Stokes Raman scattering (ERE-CARS) for measurements of nitric oxide concentration ([NO]) in three different atmospheric pressure flames. Visible pump (532 nm) and Stokes (591 nm) beams are used to probe the Q-branch of the Raman transition. A significant resonance enhancement is obtained by tuning an ultraviolet probe beam (236 nm) into resonance with specific rotational transitions in the (v’=0, v”=1) vibrational band of the A²Σ⁺–X²Π electronic system of NO. ERE-CARS spectra are recorded at various heights within a hydrogen-air flame producing relatively low concentrations of NO over a Hencken burner. Good agreement is obtained between NO ERE-CARS measurements and the results of flame computations using UNICORN, a two-dimensional flame code. Excellent agreement between measured and calculated NO spectra is also obtained when using a modified version of the Sandia CARSFT code for heavily sooting acetylene-air flames (φ=0.8 to φ=1.6) on the same Hencken burner. Finally, NO concentration profiles are measured using ERE-CARS in a laminar, counter-flow, non-premixed hydrogen-air flame. Spectral scans are recorded by probing the Q₁ (9.5), Q₁ (13.5) and Q₁ (17.5) Raman transitions. The measured shape of the [NO] profile is in good agreement with that predicted using the OPPDIF code, even without correcting for collisional effects. These comparisons between [NO] measurements and predictions establish the utility of ERE-CARS for detection of NO in flames with large temperature and concentration gradients as well as in sooting environments. PACS 07.88.+y; 42.62.Fi; 42.65.Dr     

Sorption and concentration of51Cr(VI) traces on TiO2 and ZrO2 by radioindicator study

The carrier technique has been used to concentrate Cr(VI) radiometrically by studying the carrying efficiency as a function of pH of aqueous medium, added ions, carrying capacity, amount of carrier and subsequent desorption of the activity adsorbed under optimum experimental conditions. The study shows that under optimum experimental conditions, 0.15 g of ZrO₂ and 0.25 g of TiO₂ carry 0.01 mg and 0.001 mg of chromium respectively. Further, the activity carried under the specified conditions can be recovered more or less quantitatively by leaching the carrier.     

MEASUREMENT OF CONTACT ANGLE IN A CLEARANCE-FIT PIN-LOADED HOLE

A simple experimental technique using an instrumented pin was developed for the measurement of the load-contact variation in a clearance-fit, pin-loaded hole. The method is applicable to both conducting and nonconducting materials.