Single-Pot Synthesis Method of 2-Hydroxybenzylidene-4-[(aza,thio)xanthenyl]anilines and Their Plant Growth Regulator Activity

Russian Journal of General Chemistry - The synthesis of 2-hydroxybenzylidene-4-[(aza, thio)xantenyl]anilines has been carried out via the reaction of 2-hydroxybenzaldehyde, aniline, and (aza,...     

Synthesis of 4-Methyl-2,6-di(9H-thioxanthen-9-yl)aniline

Russian Journal of Organic Chemistry - 4-Methyl-2,6-di(9H-thioxanthen-9-yl)aniline was synthesized by the reaction of 4-methylaniline with N-thioxanthenylpyridinium perchlorate in a 1: 3 ratio at...     

Amination of 5-Spiro-Substituted 3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones

The 3-hydroxy-1,5-dihydro-2H-pyrrol-2-one motif is a valuable scaffold in drug discovery. The replacement of the 3-oxy fragment in 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones-based compounds with a 3-amino one (3-amino analogs of 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones, 3-amino-1,5-dihydro-2H-pyrrol-2-ones) can play a crucial role in their biological effect. Thus, approaches to 3-amino-1,5-dihydro-2H-pyrrol-2-ones are of significant interest. We developed an approach to 5-spiro-substituted 3-amino-1,5-dihydro-2H-pyrrol-2-ones that could not be obtained using previously reported approaches (reactions of 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones with amines). The developed approach is based on the thermal decomposition of 1,3-disubstituted urea derivatives of 5-spiro-substituted 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones, which were prepared via their reaction with carbodiimides.