A Spectrophotometric Study of the Complexation of Magnesium(II) with a Number of Amino Acids in Aqueous Solutions

Russian Journal of General Chemistry - A spectrophotometric study of the complexation of magnesium(II) with glycine, L-aspartic, and L-glutamic amino acids in an aqueous solution at 298.15 K was...     

Multicomponent transformation of salicylaldehydes, 2-aminoprop-1-ene-1,1,3-tricarbonitrile,and pyrazolin-5-ones into substituted 2,4-diamino-5-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-5H-chromeno[2,3-b]pyridine-3-carbonitriles

Russian Chemical Bulletin - A new multicomponent reaction, namely, a one-pot transformation of salicylaldehydes, 2-aminoprop-1-ene-1,1,3-tricarbonitrile, and 2-pyrazolin-5-ones in the presence of...     

Multicomponent assembling of salicylaldehydes,kojic acid and malonic acid derivatives

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PASE facile and efficient multicomponent approach to the new type of 5-C-substituted 2,4-diamino-5H-chromeno[2,3-b]pyridine scaffold

The new multicomponent reaction comprises the triethylamine catalyzed assembling of salicylaldehydes, 2-aminoprop- 1-ene-1,1,3-tricarbonitrile and 3-methyl-2-pyrazolin-5-one in small amount of propanol, which affords substituted 2,4-diamino-5-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-5Hchromeno[2,3-b]pyridine-3-carbonitriles in 63–98% yields. This process is in agreement with PASE principles and opens the way to new chromeno[2,3-b]pyridine scaffold containing 3-methyl-2-pyrazolin-5-one fragment, which is promising for various biomedical applications.