排序方式: 共有31条查询结果,搜索用时 156 毫秒
1.
To determine the free concentration of a drug (propranolol) in the interstitial space in humans in vivo, seven male students were investigated by microdialysis of the periumbilical subcutaneous tissue. The microdialysis catheters were calibrated in vivo and the propranolol concentration was determined by high-performance liquid chromatography. Ten hours after intake of 80 mg of propranolol, the total plasma and free interstitial propranolol concentrations were 80 +/- 43 and 7 +/- 2 nM, respectively. After a second dose, maximum concentration was reached after 80 +/- 10 min and 98 +/- 12 min, in plasma, and the concentrations in the interstitial water were 594 +/- 138 and 27 +/- 7 nM, respectively. In a second study, microdialysis was performed on the left ventricular wall in six pigs receiving an intravenous injection of 5 mg of propranolol followed by a constant propranolol infusion for 40 min (5 mg propranolol per h). The maximum concentrations of propranolol were 97 +/- 29 and 6 +/- 2 nM in plasma and in interstitial water, respectively. The data suggest that microdialysis is a useful tool for recording the free concentrations of a drug in the interstitial space. 相似文献
2.
K.-M. Källman M. Brenner V.Z. Goldberg T. Lönnroth P. Manngård A.E. Pakhomov V.V. Pankratov 《The European Physical Journal A - Hadrons and Nuclei》2003,16(2):159-169
The excitation function and angular distributions of elastic α-particle scattering on 28Si have been measured in the laboratory energy range 6-28 MeV using a backscattering technique on a thick target, yielding
a continuous energy distribution. More than 200 narrow states are observed, with widths in the range ∼ 30-100 keV at excitation
energies E
* = 13-32 MeV. Angular distributions at backward angles were measured, and angular momentum values of more than 83 states have
been deduced. The analysis gives spin-parities J
π, α-partial widths Γα and reduced widths of the narrow high-lying resonant states in 32S. The experimentally observed states display both the negative- and the positive-parity rotational-like sequences with seemingly
no parity splitting, a finding which is at variance with most potential-model predictions. The deduced effective moment of
inertia indicates a more extended structure than the ground-state configuration. The observed strength of each ℓ-value is
analyzed in terms of an underlying split doorway state of Lorentzian form, which yields an interpretation as fragmented rotational
α + 28Si states.
Received: 26 June 2000 / Accepted: 16 September 2002 / Published online: 4 February 2003
RID="a"
ID="a"e-mail: kkallman@abo.fi
RID="b"
ID="b"Present address: Swedish Polytechnic, FIN-65200 Vasa, Finland.
Communicated by D. Guerreau 相似文献
3.
S. Yu. Torilov K. A. Gridnev V. I. Zherebchevsky M. Brenner L. I. Vinogradov V. Z. Goldberg T. V. Korovitskaya T. Lönnroth N. A. Maltsev M. Mutterer B. G. Novatskii M. Norrby J. M. K. Slotte Yu. G. Sobolev W. H. Trzaska G. P. Tyurin S. V. Khlebnikov 《JETP Letters》2011,94(1):6-10
High-spin states of the 22Ne nucleus in the excitation energy range of 15–30 MeV have been studied. The angular correlation method has been used to determine the spins of excited states. A number of new states with high angular momenta—20.0 MeV (9?), 20.7 MeV (11?), 21.6 MeV (9?), 22.2 MeV (12+), and 25.0 MeV (9?)—have been revealed. They are intensely populated in the reaction 14C(12C, α1)22Ne* → α2 + 18O and correspond to the rotational bands of various structures. 相似文献
4.
T. Weckström B. Fant T. Lönnroth V. Rahkonen A. Källberg C. -J. Herrlander 《Zeitschrift für Physik A Hadrons and Nuclei》1985,321(2):231-241
Excited states in199,200,201Po were populated in the reactions12C+194Pt and12C+195Pt. The subsequentγ-radiation was studied using conventional in-beam spectroscopic methods. States with spins up to (29/2), 18 and ≧35/2?, respectively, were populated in the three nuclides. Three isomeric states with the following half-lives were observed in200Po:T 1/2(8+)=90(15) ns,T 1/2(11?)=120(20) ns andT 1/2(12+)=267(4) ns. The structure of the excited states was interpreted within the framework of the spherical shell model. The three isomers are suggested to be two-quasiparticle states with configurationsπ(h 2 2)8J, π(h9i13/2)11- and v(i 1 3/2 ?2)12+. A self-consistent Hartree-Fock calculation was performed to obtain ground-state deformations of the neighbouring Pb cores. From the results of the experiments and the calculations it was concluded that no appreciable deformations of the cores are manifested in the yrast states of these three Po nuclei. 相似文献
5.
V. Z. Goldberg G. V. Rogachev M. Brenner K. -M. Källman T. Lönnroth M. V. Rozhkov S. Torilov W. H. Trzaska R. Wolski 《Physics of Atomic Nuclei》2000,63(9):1518-1526
Excitation functions for 32S+α elastic scattering are measured by a new method based on inverse kinematics and a thick gas target. Data corresponding to the 36Ar excitation range 12–16 MeV are treated within the R-matrix approach. Spin-parity assignments are given for over 40 new levels. 相似文献
6.
T. Lönnroth S. Vajda O. C. Kistner M. H. Rafailovich 《Zeitschrift für Physik A Hadrons and Nuclei》1984,317(2):215-223
Excited states in127, 128Xe were populated in the reaction9Be+122Sn atE lab=38 MeV. The de-excitation of the isomeric states 7/2+ in127Xe and 8? in128Xe was studied using angular distribution and TDPAD methods on molten122Sn targets. The results are $$\begin{gathered} T_{1/2} (7/2^ + ) = 37 \pm 1 ns, g(7/2^ + ) = + 0.241 \pm 0.009 \hfill \\ T_{1/2} (8^ - ) = 83 \pm 2 ns, g(8^ - ) = - 0.036 \pm 0.009. \hfill \\ \end{gathered}$$ The experimentalg-factors suggest the main configurationsvg 7/2 andvh 11/2 g 7/2 for the isomeric states. Detailed analysis of the combined information fromg-factors and transition rates set stringent limits on the admixtures of the wave functions. The quasirotational bands built on the two-quasiparticle 6? and 10+ states are extended to higher spins, (14?) and (16+), respectively, and their structures are analyzed within the framework of the Interacting Boson Model. 相似文献
7.
T. Lönnroth L. Végh K. Wikström B. Fant 《Zeitschrift für Physik A Hadrons and Nuclei》1978,287(3-4):307-317
Using alpha-particles in the energy range 35–51MeV and in-beam gamma ray and conversion electron spectroscopy techniques the reaction205Tl(α, 3n)206Bi was studied. A 15±1ns isomeric 15+ state was found at an excitation energy of 3147keV in206Bi. The main configuration of the isomeric state is suggested to beπh 9/2 vp 1 2/?1 i 13 2/?2 . The isomeric state decays mainly through a stretched cascade of five gamma rays to the previously known 0.88ms 10? state of theπh 9/2 vi 13 2/?1 (j ?2)0+ configuration at an excitation energy of 1045 keV. A shell model calculation of the yrast states has been performed and it is found that the calculation agrees fairly well with the experiments. The average deviation between experimental and calculated energies for the yrast states with angular momenta in the region 6–18 is +4keV and the root mean square deviation is 22 keV. 相似文献
8.
G. Bogaert P. Aguer G. Bastin L. Hildingsson T. Lönnroth L. Nguyen H. Sergolle F. Soramel J. P. Thibaud 《Zeitschrift für Physik A Hadrons and Nuclei》1986,324(1):107-116
Theγ ray continuum structures of the transitional Er isotopes withA~154 are studied using the reaction74Ge(84Kr,xn)158?xEr atE lab=340 MeV. The measurements include energy spectra, total energies, multiplicities, angular distributions and lifetimes using the DSAM method. The analysis of data confirms the previously observed two-bump structure of the continuum radiation. A meticulous subtraction of discrete contributions proves the persistence of the low-energy bump even at high spins, i.e.I>40?. The angular-distribution measurements assign predominant dipole structure to the bump atE γ=0.65 MeV, whereas the bump atE γ=1.3 MeV is of almost pure quadrupole character at high spins. The lifetime measurements give evidence for a strong enhancement of theB(E2) values of the upper bump,B(E2)/B sp>130. Spin-selection studies reveal, in the spin rangeI=30?50? an almost constant energy for the 1.3 MeV bump,ΔE<60 keV. 相似文献
9.
A. Kerek T. Lönnroth K. Honkanen E. der Mateosian P. Thieberger 《Zeitschrift für Physik A Hadrons and Nuclei》1984,317(2):169-171
Excited states in117I,118Xe and119I were populated in the reactions106Pd+16O and108, 110Cd+12C. The groundstate band in118Xe was observed to its (18+) member and the 11/2? bands in117I and119I to their (35/2?) and (43/2?) members, respectively. The structure of the bands in the I isotopes is interpreted as aπ h 11/2 proton coupled to an even-even band structure in Xe, and the band crossings observed in118Xe and119I are interpreted in the Cranked Shell Model framework asAB n ofv h 11/2. 相似文献
10.
H. Sergolle P. Aguer G. Bastin R. Kroth J. P. Thibaud K. Hardt T. Lönnroth F. Beck J. C. Merdinger 《Zeitschrift für Physik A Hadrons and Nuclei》1983,313(4):289-292
Using the reaction175Lu(19F, 6n) theg-factor of the188Hg isomeric state (J π=12+,T 1/2=135 ns) has been measured with the TDPAD method. The experimental value g=?0.168(10) supports the interpretation of an almost pure (vi13/2)?2 configuration for this isomer. 相似文献