Dubrovin valuation rings and Henselization

Supported in part by the National Science Foundation     

Baer orderings with noninvariant valuation ring

We construct division algebras with involution containing a Baer ordering with noninvariant order ring. This gives a negative answer to a question of Holland, whether the order ring is always invariant under inner automorphisms. Furthermore, we give examples of any index. Previously, the only known examples of division algebras containing Baer orderings were of index 2 ⁿ or of indexp forp a prime of the form 4m + 3. Supported in part by the National Science Foundation.     

Possible candidates for discrete gamma rays linking superdeformed and yrast states in an odd nucleus:193Pb

The francium isotopes^200–202Fr were produced in the reaction³⁵Cl+¹⁷⁰Yb using bombarding energies of 4.9–5.3 MeV/nucleon. Fusion products were separated in-flight from the primary beam using a gas-filled recoil separator. An alpha line with the alpha particle energy and half-life of (7468±9) keV and (19 ₋₆ ⁺¹³ ) ms, respectively, was assigned to²⁰⁰Fr. Previously reported decay properties of^201,202Fr were confirmed. Communicated by V. Metag     

Gel-permeation chromatography and cellulose. I. Effect of degree of nitration of cellulose on molecular weight distribution data

Consideration is given to the effect on gel-permeation chromatographic (GPC) data of the extent of substitution in nitrated cellulose. GPC parameters for samples containing 13.55–13.81% nitrogen (14.14% corresponds to complete substitution, DS = 3) were hardly affected by this variation in substitution. Variations that were observed are considered to arise within the samples themselves. Experiments with low molecular weight organic iodides, nitrates, and hydroxyl compounds indicate longer chain lengths than actual; this is attributed to extensive solvation of the substituent groups. The very long chain lengths obtained for cellulose nitrate by the present GPC procedure may arise from such an affect.     

A Resin‐Linker‐Vector Approach to Radiopharmaceuticals Containing 18F: Application in the Synthesis of O‐(2‐[18F]‐Fluoroethyl)‐L‐tyrosine

A Resin‐linker‐vector (RLV) strategy is described for the radiosynthesis of tracer molecules containing the radionuclide ¹⁸F, which releases the labelled vector into solution upon nucleophilic substitution of a polystyrene‐bound arylsulfonate linker with [¹⁸F]‐fluoride ion. Three model linker‐vector molecules 7 a – c containing different alkyl spacer groups were assembled in solution from (4‐chlorosulfonylphenyl)alkanoate esters, exploiting a lipase‐catalysed chemoselective carboxylic ester hydrolysis in the presence of the sulfonate ester as a key step. The linker‐vector systems were attached to aminomethyl polystyrene resin through amide bond formation to give RLVs 8 a – c with acetate, butyrate and hexanoate spacers, which were characterised by using magic‐angle spinning (MAS) NMR spectroscopy. On fluoridolysis, the RLVs 8 a , b containing the longer spacers were shown to be more effective in the release of the fluorinated model vector (4‐fluorobutyl)phenylcarbamic acid tert‐butyl ester ( 9 ) in NMR kinetic studies and gave superior radiochemical yields (RCY≈60 %) of the ¹⁸F‐labelled vector. The approach was applied to the synthesis of the radiopharmaceutical O‐(2‐[¹⁸F]‐fluoroethyl)‐L ‐tyrosine ([¹⁸F]‐FET), delivering protected [¹⁸F]‐FET in >90 % RCY. Acid deprotection gave [¹⁸F]‐FET in an overall RCY of 41 % from the RLV.