Synthesis of oxazolidinedione derived bicalutamide analogs

The synthesis of chiral oxazolidinedione derived bicalutamide analogs has been discussed.     

Synthesis of novel iodo derived bicalutamide analogs

A series of optically active nonsteroidal selective androgen receptor modulators with structures analogous to bicalutamide was prepared by replacing the trifluoromethyl group with iodine and the sulfonyl linker by oxygen.     

PRESSURE-VELOCITY EQUILIBRIUM HYDRODYNAMIC MODELS

This article describes mathematical models for phase separated mixtures of materials that are in pressure and velocity equilibrium but not necessarily temperature equilibrium. General conditions for constitutive models for such mixtures that exhibit a single mixture sound speed are discussed and specific examples are described.     

Atomic force microscopy of Au deposition from aqueous HF onto Si(111)

Non-contact atomic force microscopy (AFM) was employed following emersion to examine Au nanoclusters deposited from aqueous mixtures of HF and 10⁻⁴ M KAu(CN)₂ onto Si(111). As the HF concentration is increased, the growth rates both parallel and perpendicular to the substrate of the approximately oblate Au hemispheroids increase. AFM images were obtained for times at which previously reported in situ second harmonic generation signals from the interface reach a maximum. At the time when the second harmonic enhancement is maximized during deposition from 0.500 (5.00) M HF, the Au nanoclusters have an average diameter of 94 (109) nm and an average height of 3.6 (9.5) nm. These cluster diameters can be understood qualitatively by the shift of the plasmon resonance due to depolarization as the cluster size increases, causing the resonant second harmonic enhancement at 532 nm to pass through a maximum at cluster diameters in the range 90–110 nm.     

A 1D zinc(II) polymer with W-like pentanuclear secondary building blocks constructed by 2,6-pyridine-diacylhydrazone ligand

A 1D zinc(II) coordination polymer with W-like pentanuclear secondary building blocks constructed by 2,6-bis[(3-methoxysalicylidene)hydrazinocarbonyl]pyridine (H₄Bmshp) ligand, {[Zn₅(Bmshp)(CH₃COO)₅Cl(H₂O)₃]·2H₂O} _n , was synthesized and characterized by elemental analysis, IR, X-ray diffraction, and thermogravimetric analyses. It has the highest nuclear unit constructed by one 2,6-pyridine-diacylhydrazone ligand so far. The luminescent property of the compound was studied. It shows an emission with a maximum at 522 nm upon excitation at 450 nm.     

Bis(μ‐phenyl 2‐pyridyl ketone N4,N4‐butane‐1,4‐diylthiosemicarbazonato)bis[chlorocopper(II)]

The title compound, [Cu₂(C₁₇H₁₇N₄S)₂Cl₂], exhibits a dimeric structure related by a centre of symmetry. The monomers are linked to each other by the longest Cu—S apical distance observed to date among Cu^II square‐pyramidal complexes of N⁴‐substituted thio­semicarbazones. Each Cu^II atom deviates from the coordination square plane, which contains the pyrid­yl and imine N atoms, the thiol­ate S atom and the Cl⁻ anion, towards the S atom of the adjacent monomer. The dimers pack in a zigzag manner through the crystal.     

Structural and spectral perspectives of a novel thiosemicarbazone synthesized from di-2-pyridyl ketone and 4-phenyl-3-thiosemicarbazide

A new thiosemicarbazone, HL is synthesized from di-2-pyridyl ketone and 4-phenyl-3-thiosemicarbazide and structurally and spectrochemically characterized. 1H NMR, 13C NMR, COSY, HMQC and IR spectra of the compound are studied and the proton magnetic resonance spectrum reveals some unprecedented observations. The thione form is predominant in the solid state, as supported by the crystal structure and IR data, while a thiol-thione equilibrium is proposed in the solution state by NMR studies. The compound crystallizes into a monoclinic lattice with space group C2/c and the ZE conformation is exhibited by the thiosemicarbazone. Intra- and intermolecular hydrogen-bonding interactions give rise to a two-dimensional packing in the crystal lattice.     

Structural, spectral and antimicrobial studies of copper(II) complexes of 2-benzoylpyridine N(4)-cyclohexyl thiosemicarbazone

Six new copper(II) complexes of 2-benzoylpyridine N(4)-cyclohexyl thiosemicarbazone (HL) have been synthesized and characterized by different physicochemical techniques like molar conductivity measurements, magnetic studies and electronic, infrared and EPR spectral studies. Five of the complexes have been found to possess the stoichiometry [CuLX], where X = Cl (1), Br (2), NO₃ (3), NCS (4), N₃ (5). The complex prepared from copper sulfate has the composition [Cu₂L₂SO₄] · (H₂O)₂ (6). In all the complexes the deprotonated ligand, L and the anion were found to be coordinated to the Cu(II) ion. The terdentate nature of the ligand is evident from the IR spectra. The metal ligand bonding parameters evaluated from the EPR spectra indicate strong in-plane σ and in-plane π bonding. The magnetic and spectroscopic data indicate a square planar geometry for complexes 1, 3, 4 and 5, while the complexes 2 and 6 are assigned a square pyramidal geometry. Crystal structure of the complex [CuLCl] reveals two molecules per asymmetric unit of a monoclinic lattice, with space group symmetry P2₁/n. The complexes [ CuLBr ₂] (2) and [CuLNCS] (4) crystallized into triclinic lattices with space group . Compound 2 exists as a thiolate bridged copper(II) dimer. The antimicrobial activity of the ligand and the copper complexes were tested against five types of bacteria isolated from clinical samples. The complexes were found to be active against Bacillus sp., Vibrio cholera O1, Staphylococcus aurus and Salmonella paratyphi.