全文获取类型
收费全文 | 722篇 |
免费 | 37篇 |
国内免费 | 1篇 |
专业分类
化学 | 552篇 |
晶体学 | 11篇 |
力学 | 22篇 |
数学 | 52篇 |
物理学 | 123篇 |
出版年
2022年 | 6篇 |
2021年 | 15篇 |
2020年 | 18篇 |
2019年 | 21篇 |
2018年 | 13篇 |
2017年 | 23篇 |
2016年 | 35篇 |
2015年 | 20篇 |
2014年 | 52篇 |
2013年 | 63篇 |
2012年 | 41篇 |
2011年 | 41篇 |
2010年 | 24篇 |
2009年 | 32篇 |
2008年 | 38篇 |
2007年 | 29篇 |
2006年 | 31篇 |
2005年 | 30篇 |
2004年 | 26篇 |
2003年 | 19篇 |
2002年 | 15篇 |
2001年 | 7篇 |
2000年 | 4篇 |
1999年 | 4篇 |
1997年 | 4篇 |
1996年 | 7篇 |
1995年 | 6篇 |
1994年 | 5篇 |
1993年 | 4篇 |
1990年 | 6篇 |
1988年 | 7篇 |
1987年 | 7篇 |
1986年 | 4篇 |
1985年 | 5篇 |
1984年 | 5篇 |
1983年 | 4篇 |
1982年 | 9篇 |
1981年 | 7篇 |
1980年 | 10篇 |
1979年 | 4篇 |
1978年 | 7篇 |
1977年 | 7篇 |
1976年 | 4篇 |
1975年 | 3篇 |
1973年 | 4篇 |
1972年 | 3篇 |
1947年 | 2篇 |
1942年 | 2篇 |
1939年 | 2篇 |
1938年 | 2篇 |
排序方式: 共有760条查询结果,搜索用时 375 毫秒
1.
Synthesis of Small‐Sized,Porous, and Low‐Toxic Magnetite Nanoparticles by Thin POSS Silica Coating 下载免费PDF全文
Dr. Swee Kuan Yen D. Prathyusha Varma Wei Mei Guo Dr. Vincent H. B. Ho Dr. Vimalan Vijayaragavan Dr. Parasuraman Padmanabhan Prof. Kishore Bhakoo Prof. Subramanian Tamil Selvan 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(10):3914-3918
In this communication, we report the synthesis of small‐sized (<10 nm), water‐soluble, magnetic nanoparticles (MNPs) coated with polyhedral oligomeric silsesquioxanes (POSS), which contain either polyethylene glycol (PEG) or octa(tetramethylammonium) (OctaTMA) as functional groups. The POSS‐coated MNPs exhibit superparamagnetic behavior with saturation magnetic moments (51–53 emu g?1) comparable to silica‐coated MNPs. They also provide good colloidal stability at different pH and salt concentrations, and low cytotoxicity to MCF‐7 human breast epithelial cells. The relaxivity data and magnetic resonance (MR) phantom images demonstrate the potential application of these MNPs in bioimaging. 相似文献
2.
Palladium-catalysed three component coupling of an alkenylbromide, isonitrile and an amine or alkoxide/phenoxide affords α,β-unsaturated-amidines and -imidates. 相似文献
3.
4.
Kishore K Tiwari Girdhar L Mundhara Manish K Rai Vinay K Gupta 《Analytical sciences》2006,22(2):259-262
The results of a study and application of leucocrystal violet for the determination of antimony in parts per million levels is described here. The proposed method is based on the reaction of antimony(III) with acidified potassium iodate to liberate iodine. The liberated iodine selectively oxidizes leucocrystal violet to crystal violet dye. The formed dye shows maximum absorbance at 590 nm. The color system obeys Beer's law in the concentration range from 0.4 - 3.6 microg antimony per 25 ml of final solution. The molar absorptivity and Sandell's sensitivity were found to be 7.32 x 10(5) l mol(-1) cm(-1) and 0.0016 microg cm(-2), respectively. All variables were studied in order to optimize the reaction. The proposed method is satisfactorily applicable for the analysis of antimony in various environmental and biological samples. The method is simple, highly sensitive, accurate and reliable. 相似文献
5.
Summary The problem of the construction of an equilibrium surface taking the surface tension into account leads to Laplace-Young equation which is a nonlinear elliptic free-boundary problem. In contrast to Orr et al. where an iterative technique is used for direct solution of the equation for problems with simple geometry, we propose here an alternative approach based on shape optimization techniques. The shape of the domain of the liquid is varied to attain the optimality condition. Using optimal control theory to derive expressions for the gradient, a numerical scheme is proposed and simple model problems are solved to validate the scheme. 相似文献
6.
Vishwakarma Santosh L. Bagul Milind S. Rajani M. Goyal Ramesh K. 《平面色谱法杂志一现代薄层色谱法》2004,17(2):128-131
JPC – Journal of Planar Chromatography – Modern TLC - Swertiamarin is a secoiridoid glucoside present in members of the Gentianaceae family, including Swertia chirata (Wall) Clarke, S.... 相似文献
7.
A. Lakshmi Sailaja K. Kishore Kumar D. V. R. Ravi Kumar C. Mohan Kumar N. M. Yugandhar G. Srinubabu 《Chromatographia》2007,65(5-6):359-361
A simple, rapid, and sensitive high-performance liquid chromatographic method for estimation of efavirenz in human plasma
has been developed and validated. Chromatography was performed with C18 analytical column and 50:50 acetonitrile–phosphate buffer (pH 3.5) as mobile phase. Compounds were monitored by UV detection
at 247 nm. The retention time for efavirenz was 6.45 min and that for the internal standard, nelfinavir, was 2.042 min. Response
was a linear over the concentration range of 0.1 μg–10 μg mL−1 in human plasma. The method was simple, specific, precise and accurate and was useful for bioequivalence and pharmacokinetic
studies of efavirenz. 相似文献
8.
The direct oxidation of chiral amide enolates to optically active mandelic acid using 2-sulfonyloxaziridine is described. The diastereoselectivity is counterion dependent. 相似文献
9.
Cytochrome P-450 isozymes represent a critical component of nature’s spectrum of detoxification catalysts that could be exploited
for bioremediation. The ethanol-inducible human cytochrome P-450 2E1 serves as a model eukaryotic P-450 that complements the
bacterial P-450 cam in dehalogenation and detoxification of environmental pollutants. We explored the construction of novel
chimeric P-450s using cytochrome P-450 camC and 2E1 genes. For construction of chimera 1 (478 amino acids, 55.14 kDa), 145 amino acids from the N-terminus of P-450 2E1 protein
(493 amino acids, 56.84 kDa) were replaced with 130 amino acids from the N-terminus of P-450 camC protein (415 amino acids,
46.66 kDa). In chimera 2 (525 amino acids, 60.24 kDa) the strategy involves replacement of 28 amino acids in the C-terminus
of chimera 1 with 75 amino acids from the C-terminus of P-450 camC gene. Homology models of both the chimeric proteins were
developed using SWISS-MODEL based on the known crystal structure of cytochrome P-450 camC, BM-3, 1DT6A, and 2C17A. The models
indicated that the proposed heme-binding site was intact, which is inevitable for catalytic activity of cytochrome P-450s.
The expression of chimera 1 and 2 genes in Escherichia coli DH5α was evident from light-pink cell pellets, protein band in sodium dodecyl sulfate polyacrylamide gel electrophoresis,
and diagnostic carbon monoxide-difference spectra. Our studies show that strategies can be developed to exploit the natural
diversity of the P-450 superfamily to generate chimeric biocatalysts that would provide new templates amenable to directed
evolution. 相似文献
10.
Densities and apparent molar volumes of aqueous 2-chloroethanol were determined at temperatures from 15.0 to 34.4°C using digital densimetry. The results of the volumetric measurements have been used to calculate the following thermodynamic quantites at 25°C: V
2
o = 55.05 ± 0.02 cm3-mol–1, (V
2
o/T)p = 0.01486 ± 0.00318 cm3-K–1-mol–1, and (2
V
2
o/T
2)p = 0.02972 ± 0.00318 cm3-K–2-mol–1. Partial molar volumes of transfer from water to 1 mol-dm–3 2-chloroethanol have also been determined for L-glycine, L-alanine, L-serine, L-glutamic acid, and L-aspartic acid at 35.0°C. The transfer results have been explained in terms of the nature of the interactions of the groups in the solute and solvent. Hydration numbers of L-glycine and L-alanine have also been calculated in aqueous 2-chloroethanol. 相似文献