Synthetic studies in the field of the porphyrins. synthesis of a mesoporphyrin and of a diacetyldeuteroporhyrin

A method is proposed for the synthesis of porphyrins based on the cyclization of a tetrapyrrole system with methyl and formyl groups at the ends of the molecule. The synthesis of mesoporphyrin IX and diacetyldeuteroporphyrin IX has been effected.     

New test tools for determination of trace metals using polydentate cellulose

New test tools have been developed for the rapid determination of trace metals: Ag, Cd, Co, Cu(II), Fe(II,III), Hg(II), Pd and Zn, using polydentate irregular α-celluloses, containing in the 6 position the fragments heterylformazane or heterylhydrazone, with a pocket device for preconcentration. Received: 17 June 1997 / Revised: 1 November 1997 / Accepted: 6 November 1997     

Synthesis and spectrophotometric study of some amino derivatives of thiophene analogs of chalcone

Eight amino derivatives of thiophene analogs of chalcone were obtained by reduction of the corresponding nitro derivatives with stannous chloride in concentrated hydrochloric acid, and their UV absorption spectra in dioxane were measured. The long-wave band was assigned to the corresponding fragments of the molecule on the basis of a comparison of the absorption curves of the investigated compounds with the curves of simpler compounds — aminoacetophenone, aminobenzalacetone, acetothienone, etc.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 198–203, February, 1977.     

Matter-wave gap solitons in atomic band-gap structures

We demonstrate that a Bose-Einstein condensate in an optical lattice forms a reconfigurable matter-wave structure with a band-gap spectrum, which resembles a nonlinear photonic crystal for light waves. We study in detail the case of a two-dimensional square optical lattice and show that this atomic band-gap structure allows nonlinear localization of atomic Bloch waves in the form of two-dimensional matter-wave gap solitons.     

Ferrocene‐modified thiopyrimidines: synthesis,enantiomeric resolution,antitumor activity

Ferrocenylalkyl thiopyrimidines ( 6a–d to 9a–d ) were prepared via the reaction of the α‐(hydroxy)alkyl ferrocenes, FcCHR(OH) ( 1a–d ; Fc = ferrocenyl; R = H, Me, Et, Ph), with 2‐thiopyrimidines ( 2 – 5 ) in acetone at room temperature in the presence of TFA, yielding 50–95%. The resulting enantiomers were resolved using HPLC on modified cellulose as chiral selector. The antitumor activities of S‐ferrocenylethyl 2‐thiopyrimidine ( 6b ) against two murine solid tumor models, carcinoma 755 (Ca755) and Lewis lung carcinoma (LLC) were evaluated in vivo. The strong antitumor effect of compound 6b on Ca755 and LLC was demonstrated. The index of tumor growth inhibition on Ca755 equaled 95% in comparison with control. Copyright © 2010 John Wiley & Sons, Ltd.