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Richard J. Sundberg D. J. Dahlhausen G. Manikumar B. Mavunkel Atanu Biswas V. Srinivasan Fred King Philip Waid 《Journal of heterocyclic chemistry》1988,25(1):129-137
A series of substituted 2-aryl imidazo[1,2-a]pyridines has been prepared in which a variety of substituents are introduced on the 4′-position of the phenyl ring and on the 3, 5 , 6 or 7 position of the heterocyclic ring. Most examples have acetamido, bromo, cyano, or formyl substituents at the 4′-position. Analogous imidazo-[2,1-b]fhiazoles and imidazo[1,2-a]pyrimidines have also been prepared. Another series of compounds consisting of 4′-formylphenoxymethyl derivatives of imidazole, the three positional isomers of pyridine, thiazole, benzimidazole and ring-substituted imidazo[1,2-a]pyridines has been prepared. 2-(4′-Formylphenylethenyl) derivatives of imidazole and imidazo[1,2-a]pyridine were also prepared. 相似文献
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Perumattam John Chakravarty Sarvajit McEnroe Glenn A. Goehring R. Richard Mavunkel Babu Suravajjala Sandhya Smith Whitney W. Chen Baili 《Molecular diversity》1997,3(2):121-128
A simple and general approach to the synthesis of chemical libraries based on a universal anhydride template allows the preparation
of large number of compounds. Various cyclic/acyclic amines, primary/secondary amines, differentially protected bifunctional
amines were used as nucleophiles to react with anhydrides. The free carboxylic acid generated was then coupled with solid-bound
amines. The facile and rapid generation of compounds through this multi-component assembly can be accomplished in a combinatorial
parallel synthesis.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
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