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Chua-anusorn Wanida Mun Hyang-Ran Webb John Gorham Nicole T. Pierre Timothy G. St. 《Hyperfine Interactions》2002,144(1-4):279-288
Hyperfine Interactions - Horse spleen apoferritin was reconstituted with varying numbers of iron atoms per protein shell at 25 and 50°C. Samples with mean particle sizes ranging from... 相似文献
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Won Kon Kim Hyang-Ran Hwang Do Hyung Kim Phil Young Lee Yu Jung In Hye-Young Ryu Sung Goo Park Kwang-Hee Bae Sang Chul Lee 《Experimental & molecular medicine》2008,40(6):677-685
Atopic dermatitis (AD) is an inflammatory skin disorder that is both uncomfortable and distressing to patients, and its prevalence has been steadily increasing. It is obvious that the identification of efficient markers of AD in plasma would offer the possibility of effective diagnosis, prevention, and treatment strategies. In this study, a proteomic approach was used to analyze plasma glycoproteins from both children with AD and healthy child donors. Several protein spots showing significant quantitative changes in the AD patients were identified. Through sequential studies, it was confirmed that CD5L and ApoE were significantly up-regulated or down-regulated, respectively, in the plasma from AD patients compared with that from healthy donors. In addition, we suggest that the up-regulated CD5L in AD patients causes eosinophilia by inhibiting apoptosis or promoting the proliferation of eosinophils either in combination with or without IL-5. The glycoproteomic data in this study provides clues to understanding the mechanism of atopic alterations in plasma and suggests AD-related proteins can be used as candidate markers for AD. 相似文献
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