排序方式: 共有26条查询结果,搜索用时 312 毫秒
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Sanford TW Allshouse GO Marder BM Nash TJ Mock RC Spielman RB Seamen JF McGurn JS Jobe D Gilliland TL Vargas M Struve KW Stygar WA Douglas MR Matzen MK Hammer JH De Groot JS Eddleman JL Peterson DL Mosher D Whitney KG Thornhill JW Pulsifer PE Apruzese JP Maron Y 《Physical review letters》1996,77(25):5063-5066
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If the potential of a scalar field phi which currently provides the "dark energy" of the Universe has a minimum at phi = -M(0)(4)<0, then quantum-mechanical fluctuations could nucleate a bubble of phi at a negative value of the potential. This bubble would then expand at the speed of light. Given that no such bubble enveloped us in the past, we find that any minimum in V(phi) must be separated from the current phi value by more than min[1.5M(0),0.21M(Pl)], where M(Pl) is the Planck mass. We also show that vacuum decay renders a cyclic or ekpyrotic universe with M(0)(4) > or approximately 10(-10)M(4)(Pl) untenable. 相似文献
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A. Panchaud C. Reichard N. A. Orlow E. Gabutti Anton Altan Wald Hille H. M. Gordin W. Bickern Albert Beitter Georg Heyl H. F. Moschkowitsch Léger Farr Wright Barral Garsed Ed. Dowzard E. Rupp O. Schweissinger Busse Fränkel und Karl Dieterich 《Fresenius' Journal of Analytical Chemistry》1907,46(6-7):463-476
Ohne Zusammenfassung 相似文献
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An integral equation formulation for buoyancy-driven convection problems is developed and illustrated. Buoyancy-driven convection in a bounded cylindrical geometry with a free surface is studied for a range of aspect ratios and Nusselt numbers. The critical Rayleigh number, the nature of the cellular motion, and the heat transfer enhancement are computed using linear theory. Green's functions are used to convert the linear problem into linear Fredholm integral equations. Theorems are proved which establish the properties of the eigenvalues and eigenfunctions of the linear integral operator which appears in these equations. 相似文献
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Georg Heyl 《Analytical and bioanalytical chemistry》1918,57(11-12):584-584
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Figueroa H Peddi D Osborne JM Wilson BM Pesaru RR Kurva B Ramaraju S Milletti MC Heyl DL 《Journal of chemical information and modeling》2012,52(5):1298-1307
Human islet amyloid polypeptide (hIAPP) forms cytotoxic fibrils in type-2 diabetes and insulin is known to inhibit formation of these aggregates. In this study, a series of insulin-based inhibitors were synthesized and assessed for their ability to slow aggregation and impact hIAPP-induced membrane damage. Computational studies were employed to examine the underlying mechanism of inhibition. Overall, all compounds were able to slow aggregation at sufficiently high concentrations (10× molar excess); however, only two peptides showed any inhibitory capability at the 1:1 molar ratio (EALYLV and VEALYLV). The results of density functional calculations suggest this is due to the strength of a salt bridge formed with the Arg11 side chain of hIAPP and the inhibitors' ability to span from the Arg11 to past the Phe15 residue of hIAPP, blocking one of the principal amyloidogenic regions of the molecule. Unexpectedly, slowing fibrillogenesis actually increased damage to lipid membranes, suggesting that the aggregation process itself, rather than the fibrilized peptide, may be the cause of cytotoxicity in vivo. 相似文献