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1.
Monomeric sarcosine oxidase (mSOx) fusion with the silaffin peptide, R5, designed previously for easy protein production in low resource areas, was used in a biosilification process to form an enzyme layer electrode biosensor. mSOx is a low activity enzyme (10–20 U/mg) requiring high amounts of enzyme to obtain an amperometric biosensor signal, in the clinically useful range <1 mM sarcosine, especially since the Km is >10 mM. An amperometric biosensor model was fitted to experimental data to investigate dynamic range. mSOx constructs were designed with 6H (6×histidine) and R5 (silaffin) peptide tags and compared with native mSOx. Glutaraldehyde (GA) cross‐linked proteins retained ~5 % activity for mSOx and mSOx‐6H and only 0.5 % for mSOx‐R5. In contrast R5 catalysed biosilification on (3‐mercaptopropyl) trimethoxysilane (MPTMS) and tetramethyl orthosilicate (TMOS) particles created a ‘self‐immobilisation’ matrix retaining 40 % and 76 % activity respectively. The TMOS matrix produced a thick layer (>500 μm) on a glassy carbon electrode with a mediated current due to sarcosine in the clinical range for sarcosinemia (0–1 mM). The mSOx‐R5 fusion protein was also used to catalyse biosilification in the presence of creatinase and creatininase, entrapping all three enzymes. A mediated GC enzyme linked current was obtained with dynamic range available for creatinine determination of 0.1–2 mM for an enzyme layer ~800 nm. 相似文献
2.
Elizabeth S. Senger 《School science and mathematics》1997,97(3):139-149
Thirteen fifth graders were given an assignment to invent their own numeration systems, following a unit on bases and a look at early events in the history of numbers. The task presented options that required the students to make decisions (such as whether to use a base, which base to use, design of symbols, etc.), and build a rationale for the elements of their system. Analyses of patterns embedded in their invented systems provided an assessment of student understanding of numeration. The progression of more and less complex thinking related to the student's choice of a base other than 10, consistency of logic throughout the system in words and symbols, rationale for change, and perception of real life examples that would change if the system was adopted. The invention task is presented as another way to make connections. 相似文献
3.
Peixiang Xing Gilles P. Robertson Michael D. Guiver Serguei D. Mikhailenko Serge Kaliaguine 《Journal of polymer science. Part A, Polymer chemistry》2004,42(12):2866-2876
A series of sulfonated poly(aryl ether ketone)s (SPAEKs) were prepared by aromatic nucleophilic polycondensation of 2,6‐dihydroxynaphthalene with 5,5′‐carbonyl‐bis(2‐fluorobenzenesulfonate) and 4,4′‐difluorobenzophenone. The structure and degree of sulfonation (DS) of the SPAEKs were characterized using 1H NMR spectroscopy. The experimentally observed DS values were close to the expected values derived from the starting material ratios. The thermal stabilities of the SPAEKs were characterized by thermogravimetric analysis, which showed that in acid and sodium salt forms they were thermally stable in air up to about 240 and 380 °C, respectively. Transparent membranes cast from the directly polymerized SPAEKs exhibited good mechanical properties in both dry and hydrated states. The dependence of water uptake and of membrane swelling on the DS at different temperatures was studied. SPAEK membranes with a DS from 0.72 to 1.60 maintained adequate mechanical properties after immersion in water at 80 °C for 24 h. The proton conductivity of SPAEK membranes with different degrees of sulfonation was measured as a function of temperature. The proton conductivity of the SPAEK films increased with increased DS, and the highest room temperature conductivity (4.2 × 10?2 S/cm) was recorded for a SPAEK membrane with a DS of 1.60, which further increased to 1.1 × 10?1 S/cm at 80 °C. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 2866–2876, 2004 相似文献
4.
Accreditation and Quality Assurance - 相似文献
5.
Elizabeth Wulcan 《Arkiv f?r Matematik》2007,45(1):157-178
With a given holomorphic section of a Hermitian vector bundle, one can associate a residue current by means of Cauchy–Fantappiè–Leray
type formulas. In this paper we define products of such residue currents. We prove that, in the case of a complete intersection,
the product of the residue currents of a tuple of sections coincides with the residue current of the direct sum of the sections. 相似文献
6.
Frank H.G.M. Wijnands Charles G. Crookes Paul M. Charles Richard M. Ash Ian F. Lealman Michael J. Robertson Anthony E. Kelly Kevin A. Williams Aeneas B. Massara Richard V. Penty Ian H. White 《Optical and Quantum Electronics》2002,34(10):959-973
An anomalous modulation in the wavelength spectrum has been observed in lasers with spot-size converters. This intensity modulation is shown to be caused by beating between the fundamental lasing mode and radiation modes in the taper. This results in a periodic modulation in the net gain spectrum, which causes wavelength jumps between adjacent net gain maxima, and a drive current dependent spectral width that is expected to affect system performance. The amplitude of this spectral modulation is reduced significantly by either using an angled rear-facet which reflects the beating radiation modes away from the laser axis, or by using a nonlinear, adiabatic taper. 相似文献
7.
8.
Motivated by the central limit problem for convex bodies, we study normal approximation of linear functionals of high-dimensional
random vectors with various types of symmetries. In particular, we obtain results for distributions which are coordinatewise
symmetric, uniform in a regular simplex, or spherically symmetric. Our proofs are based on Stein’s method of exchangeable
pairs; as far as we know, this approach has not previously been used in convex geometry. The spherically symmetric case is
treated by a variation of Stein’s method which is adapted for continuous symmetries.
This work was done while at Stanford University. 相似文献
9.
Radical reaction of a series of N-(2-bromoallyl)arylcarboxamides led to the production of 4-arylpyrrolidin-2-ones and directly reduced materials in comparable yields. A cascade process, involving sequential 5-exo-trig spirocyclisation, β-scission, and 5-endo-trig cyclisation of the resulting acyl radical, is proposed to explain the pyrrolidinone products. 相似文献
10.