Natural relations between the Cabibbo angle and quark masses in SU(2) L ×U(1) with four flavours

A complete classification of all possible natural relations between the Cabibbo angleΘ _c and quark masses is given which follow from an arbitrary horizontal symmetryH (discrete or continuous) and the standard gauge group SU(2) _L ×U(1) with four quark flavours. It is shown that such relations depend basically only on the dimensions of the fermion and Higgs representations and that they are therefore identical for allH with representations of the same dimensions and with the same Clebsch-Gordan series for the relevant Kronecker products. IfΘ _c depends on quark masses only, then eitherΘ _c ?m _d /m _s or \(\Theta _C \simeq m_d /\sqrt {2 m_s } \) . In particular, the phenomenologically successful relation \(\Theta _C \simeq \sqrt {m_d /m_s } \) cannot be obtained in a natural way in the 4-flavour SU(2) _L ×U(1) model for any horizontal symmetry.     

Empowering pharmacoinformatics by linked life science data

With the public availability of large data sources such as ChEMBLdb and the Open PHACTS Discovery Platform, retrieval of data sets for certain protein targets of interest with consistent assay conditions is no longer a time consuming process. Especially the use of workflow engines such as KNIME or Pipeline Pilot allows complex queries and enables to simultaneously search for several targets. Data can then directly be used as input to various ligand- and structure-based studies. In this contribution, using in-house projects on P-gp inhibition, transporter selectivity, and TRPV1 modulation we outline how the incorporation of linked life science data in the daily execution of projects allowed to expand our approaches from conventional Hansch analysis to complex, integrated multilayer models.     

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Isospin violation in epsilon'

On the basis of a next-to-leading-order calculation in chiral perturbation theory, the first complete analysis of isospin breaking for direct CP violation in K0-->2 pi decays is performed. We find a destructive interference between three different sources of isospin violation in the CP violation parameter epsilon'. Within the uncertainties of large-N(c) estimates for the low-energy constants, the isospin violating correction for epsilon' is below 15%.