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1.
Hettiarachchi K Green CE Ramanathan-Girish S Wu B Jackson CJ Ridge S Salem MA Lanser ME 《Journal of chromatography. A》2001,924(1-2):471-481
This paper describes a pharmacokinetic study performed in Sprague-Dawley rats after i.v. administration of a single 6-mg/kg dose of 2beta-carbomethoxy-3beta-(4-fluorophenyl)-N-(3-iodo-E-allyl)nortropane (Altropane). Plasma samples were collected from the retro-orbital sinus at times up to 3 h after drug administration, extracted by solid-phase extraction, and the drug levels determined by capillary electrophoresis (CE). Pharmacokinetic parameters were determined by a standard noncompartmental model using WinNonlin version 1.5. The maximum plasma concentrations, clearances of the drug, and areas under the curve for male and female rats were 5.74 and 7.26 microg/ml, 135.7 and 98.5 ml/kg x min, and 44.23 and 60.92 microg x min/ml, respectively. The drug was cleared very rapidly from the systemic circulation, with a terminal t(1/2) of 7 to 10 min and a mean residence time of about 11 min for both sexes. The volume of distribution was approximately 1 l/kg. No metabolites were detected when the samples were analyzed individually. However, after samples were pooled and concentrated, traces of two unknown peaks that may represent metabolites were detected in concentrates from the last two timepoints. Part I of this work [J. Chromatogr. A, 895 (2000) 87] describes validation of CE methods for the analysis of aqueous and plasma samples of Altropane, including its solid-phase extraction from rat plasma. 相似文献
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3.
Jeffrey M. Spraggins Julie A. Lloyd Murray V. Johnston Julia Laskin Douglas P. Ridge 《Journal of the American Society for Mass Spectrometry》2009,20(9):1579-1592
The gas-phase fragmentation reactions of singly charged angiotensin II (AngII, DR+VYIHPF) and the ozonolysis products AngII+O (DR+VY*IHPF), AngII+3O (DR+VYIH*PF), and AngII+4O (DR+VY*IH*PF) were studied using SID FT-ICR mass spectrometry, RRKM modeling, and molecular dynamics. Oxidation of Tyr (AngII+O)
leads to a low-energy charge-remote selective fragmentation channel resulting in the b
4
+O fragment ion. Modification of His (AngII+3O and AngII+4O) leads to a series of new selective dissociation channels. For
AngII+3O and AngII+4O, the formation of [MH+3O]
+
−45 and [MH+3O]
+
−71 are driven by charge-remote processes while it is suggested that b
5
and [MH+3O]
+
−88 fragments are a result of charge-directed reactions. Energy-resolved SID experiments and RRKM modeling provide threshold
energies and activation entropies for the lowest energy fragmentation channel for each of the parent ions. Fragmentation of
the ozonolysis products was found to be controlled by entropic effects. Mechanisms are proposed for each of the new dissociation
pathways based on the energies and entropies of activation and parent ion conformations sampled using molecular dynamics. 相似文献
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L. Pelet L. Grand R. Haller T. B. Bright E. Knecht Eva Hibbert C. Birtwell D. A. Clibbens B. P. Ridge W. D. Bancroft W. M. Clark und W. O. Snelling 《Fresenius' Journal of Analytical Chemistry》1937,109(5-6):235-238
Ohne Zusammenfassung 相似文献
6.
Ridge Michael P. Ylagan Eric Jaewon Lee Dr. Daniela E. Negru Dr. Paolo Ricci Bohyun Park Haram Ryu Prof. Dr. Mu-Hyun Baik Prof. Dr. P. Andrew Evans 《Angewandte Chemie (International ed. in English)》2023,62(23):e202300211
An enantioselective rhodium(I)-catalyzed Pauson–Khand reaction (PKR) using 1,6-chloroenynes that contain challenging 1,1-disubstituted olefins is described. In contrast to the previous studies with these types of substrates, which are only suitable for a single type of tether and alkyne substituent, the new approach results in a more expansive substrate scope, including carbon and heteroatom tethers with polar and non-polar substituents on the alkene. DFT calculations provide critical insight into the role of the halide, which pre-polarizes the alkyne to lower the barrier for metallacycle formation and provides the proper steric profile to promote a favorable enantiodetermining interaction between substrate and chiral diphosphine ligand. Hence, the chloroalkyne enables the efficient and enantioselective PKR with 1,6-enynes that contain challenging 1,1-disubstituted olefins, thereby representing a new paradigm for enantioselective reactions involving 1,6-enynes. 相似文献
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The reaction kinetics of ammonium bisulfate clusters with dimethylamine (DMA) gas were investigated using Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS). Clusters ranged in size from 1 to 10 bisulfate ions. Although displacement of the first several ammonium ions by DMA occurred with near unit efficiency, displacement of the final ammonium ion was cluster size dependent. For small clusters, all ammonium ions are exposed to incoming DMA molecules, allowing for facile exchange ("surface" exchange). However, with increasing cluster size, an ammonium ion can be trapped in an inaccessible region of the cluster ("core" exchange), thereby rendering exchange difficult. DMA was also observed to add onto existing dimethylaminium bisulfate clusters above a critical size, whereas ammonia did not add onto ammonium bisulfate clusters. The results suggest that as the cluster size increases, di-dimethylaminium sulfate formation becomes more favorable. The results of this study give further evidence to suggest that ambient sub-3 nm diameter particles are likely to contain aminium salts rather than ammonium salts. 相似文献
9.
J. Barritt R. T. Mease F. Garelli B. Saladini M. Harris H. A. Neville W. C. Fritz . Phillips A. P. Mathews A. Itkina Plechan H. Pauly E. Mönch M. C. Marsh A. P. Sakoschtschikow R. Smith J. Ph. Peper T. Dokkum S. N. Schoorl D. A. Clibbens B. P. Ridge F. RSiefert H. Wolff und K. Lindner 《Fresenius' Journal of Analytical Chemistry》1936,105(5-6):222-240
Ohne Zusammenfassung 相似文献
10.
The present study demonstrates the feasibility of the eta5-cyclopentadienylcobalt ion (CpCo*+) as a suitable cationization reagent for saturated hydrocarbon analysis by mass spectrometry. Ion/molecule reactions of CpCo*+ and three medium chain-length n-alkanes were examined using Fourier-transform ion cyclotron resonance mass spectrometry. Second-order rate constants and reaction efficiencies were determined for the reactions studied. Loss of two hydrogen molecules from the CpCo-alkane ion complex was found to dominate all reactions ( > or = 80%). Furthermore, this dehydrogenation reaction efficiency increases with increasing chain length. These preliminary results suggest that the CpCo*+ ion may be a promising cationization reagent of longer chain saturated hydrocarbons and polyolefins. 相似文献