4-(Isoindolin-5-yl)amino-4-oxobutyryl-β-alkoxyphenyl-β-alanines, new RGDF mimetics. Synthesis, affinity to fibrinogen receptors, antiaggregatory properties, and their correlation with the hydrophobicity

A new series of RGDF mimetics, derivatives of 4-(isoindolin-5-yl)amino-4-oxobutanoic acid, was synthesized. The compounds obtained inhibit efficiently the thrombocytes aggregation in experiments in vitro; their biological targets are fibrinogen receptors. The antiaggregatory activity and the affinity correlate with the hydrophobicity of the compounds.     

On the problem of describing pairs of commuting Hankel complex matrices

Solutions of two partial problems arising in the course of classifying pairs of commuting Hankel complex matrices are presented.     

Corrosion Behavior of Quasi-Crystalline Alloys of the Al–Cu–Fe–Cr System in Alkaline Media

Russian Journal of Electrochemistry - The electrochemical behavior of three alloys of different composition in the system Al65Cu25Fe10 – хCrх is studied by the potentiodynamic...     

Generation of Electric Fields and Currents in the Earth's Ionosphere Within the Framework of the Planetary-Generator Model

We present a solution for the problem of generation of electric fields and currents in the lower ionosphere of the Earth due to the nonuniform rotation of the magnetized planet and its plasma envelope with inhomogeneous conductivity (the planetary generator model). The angular velocity _p(r,) and the conductivity profile (r) of the plasma envelope are specified taking into account the experimental data. It is shown that under these conditions, the current system of the planetary generator is a single current loop localized mainly in a narrow layer corresponding to the high-conductivity region at heights h₁100 km. The thickness of this layer is about the conductivity scale. Within the framework of this model, we estimate the total current circulating in the ionosphere and the current flowing in the planet and calculate the characteristic values of the electric fields generated. Comparison between the calculation results and the experimental data shows that the considered mechanism of current generation can be significant for analyzing current systems in the lower ionosphere of the Earth.     

Global magnetospheric perturbations stimulated by the plasma wave discharge in the lower ionosphere

In this paper we discuss a new method of controlled stimulation of global perturbations and the diagnostics of plasma physical processes in the ionosphere and the magnetosphere of the Earth. The method was realized with a series of rocket experiments by means of excitation of the radio frequency plasma wave discharge in the near field of the dipole antenna [1–4]. We focus considerable attention on the results obtained in these experiments testifying to the wide choice and diversity of potentialities of this new method.Radiophysical Research Institute. Nizhny Novgorod, Russia. Published in Izvestiya Vysshikh Uchebnykh Zavedenii, Radiofizika, Vol. 37, No. 6, pp. 799–806, June, 1994.