Multivariate analysis of dynamical processes

The analysis of multi-dimensional biomedical systems requires analysis techniques, which are able to deal with multivariate data consisting of both time series as well as point processes. Univariate and bivariate analysis techniques in the frequency domain for time series and point processes are established and investigated, although the number of investigations is strongly biased towards time series. Actual multivariate techniques for time series or hybrids of time series and point processes are scarcely addressed. Here, we present spectral analysis techniques which are able to analyse point processes as well as time series. Thereby, univariate, bivariate as well as multivariate techniques are discussed. Applications to simulated as well as real-world data reveal the abilities of the proposed techniques.     

A quantitative evaluation of the reliability of calculated decay properties of nuclei in the mass region A=24−28

Electromagnetic transition rates and logft values were calculated for transitions between positive-parity states in theA=24?28 mass region. The wave functions used were taken from a previous paper. In general we found satisfactory agreement with experiment. In order to have a measure of the stability of the results against changes in the Hamiltonian a method was developed for assigning errors to calculated transition properties. The renormalized single-particle matrix elements of theE2 andM 1 transition operators were determined in a phenomenological way. To this end use was made of the errors just mentioned. It was found that good agreement was obtained with bare-nucleonM 1 singleparticle matrix elements and a state independent effective isoscalar charge for theE 2 operator. Predictions for static moments are given.     

An open source protein gel documentation system for proteome analyses

Data organization and data mining represents one of the main challenges for modern high throughput technologies in pharmaceutical chemistry and medical chemistry. The presented open source documentation and analysis system provides an integrated solution (tutorial, setup protocol, sources, executables) aimed at substituting the traditionally used lab-book. The data management solution provided incorporates detailed information about the processing of the gels and the experimental conditions used and includes basic data analysis facilities which can be easily extended. The sample database and User-Interface are available free of charge under the GNU license from http://webber.physik.uni-freiburg.de/~fallerd/tutorial.htm.     

A practical synthesis of gramicidin s and sugar amino Acid containing analogues

A practical gram-scale and high-yielding synthesis of the antimicrobial peptide gramicidin S is presented. An Fmoc-based solid-phase peptide synthesis protocol is employed for the generation of the linear decapeptide precursor, which is cyclized in solution to afford the target compound. The versatility of our method is demonstrated by the construction of eight gramicidin S analogues (15a-h) having nonproteinogenic sugar amino acid residues (4-7) incorporated in the turn regions.     

Coordination mechanisms for inventory control in three-echelon serial and distribution systems

This paper is concerned with the coordination of inventory control in three-echelon serial and distribution systems under decentralized control. All installations in these supply chains track echelon inventories. Under decentralized control the installations will decide upon base stock levels that minimize their own inventory costs. In general these levels do not coincide with the optimal base stock levels in the global optimum of the chain under centralized control. Hence, the total cost under decentralized control is larger than under centralized control. To remove this cost inefficiency, two simple coordination mechanisms are presented: one for serial systems and one for distribution systems. Both mechanisms are initiated by the most downstream installation(s). The upstream installation increases its base stock level while the downstream installation compensates the upstream one for the increase of costs and provides it with a part of its gain from coordination. It is shown that both coordination mechanisms result in the global optimum of the chain being the unique Nash equilibrium of the corresponding strategic game. Furthermore, all installations agree upon the use of these mechanisms because they result in lower costs per installation. The practical implementation of these mechanisms is discussed.     

Non-parametric identification of non-linear oscillating systems

The problem of system identification from a time series of measurements is solved by using non-parametric additive models. Having only few structural information about the system, a non-parametric approach may be more appropriate than a parametric one for which detailed prior knowledge is needed. Based on non-parametric regression, the functions in the additive models are estimated by a penalized least-squares approach using backfitting. The optimal smoothing parameters are determined via generalized cross-validation, making this approach completely adaptive to the data. The procedure is applied to identify the non-linear restoring force of vibrationally excited helical wire rope isolators.     

Stochastic global optimization methods part II: Multi level methods

In Part II of our paper, two stochastic methods for global optimization are described that, with probability 1, find all relevant local minima of the objective function with the smallest possible number of local searches. The computational performance of these methods is examined both analytically and empirically.     

Stereoselective total synthesis of aminoiminohexitols via carbamate annulation

New methodology for the preparation of a variety of aminoiminohextitols is described. Key in the synthesis is the application of a diastereoselective Strecker reaction and the extension of our carbamate annulation methodology to protected and functionalized alkenylamines. Insight into the effects that the substitution patterns of the alkenylamines have on the diastereoselectivity of the iodocyclization and carbamate annulation is discussed. An evaluation of the glycosidase inhibitory activity of the aminoiminohexitols and derivatives is also presented, with the previously undisclosed D-talo isomer showing good selective inhibition of β-D-glucosidase.     

Die PrÄmienanpassungsautomatik in der Krankenversicherung

Blätter der DGVFM - Die PrÄmienanpassungsautomatik in der deutschen privaten Krankenversicherung wurde aus einer Notlage heraus entwickelt. Diese Notlage war durch den immensen Anstieg...