Gas chromatographic determination of ifosfamide in microvolumes of urine and plasma.

In oncology, particularly in pediatric malignancies, high doses (5-10 g/m2) of the oxazaphosphorine ifosfamide play an important role in the treatment of sarcomas. Pharmacokinetic data of ifosfamide and its metabolites in these cases are scanty. Considering the special demands of the determination of ifosfamide in plasma of young children, a very sensitive capillary gas chromatographic method, requiring only 50 microliters of plasma, has been developed. This bioanalysis of ifosfamide shows good linearity and accuracy in the concentration range 10 ng to 100 micrograms per ml of plasma and 25 ng to 1 mg per ml of urine. The absolute limits of detection in plasma and urine are 2 ng/ml and 5 ng/ml, respectively. The stability of various solutions of ifosfamide and trofosfamide was tested and proved to be satisfactory, except for ifosfamide in plasma and urine kept in the refrigerator. The validity of the method for pharmacokinetic purposes is shown in the case of one patient.     

A uniform estimate for fourier transforms of measures on polynomial curves in ℝ n

We prove a uniform estimate for the decrease of the fourier transforms of smooth measures on polynomial curves in ⁿ . Our estimate improves the estimate recently obtained byW. Stadje.     

On asymmetry of some convex bodies

We determine Minkowski's measure of asymmetry for convex hulls of a point and some sets for which the asymmetry is known. Some properties of the asymmetry measure are found which may indicate some interesting properties of convex bodies. Received March 1, 2001, and in revised form June 29, 2001. Online publication December 17, 2001.     

On a theorem of Karlin

Starting from an old result of S. Karlin, we demonstrate the usefulness of couplings within the theory of random systems with complete connections. We also give a short exposé of some limit results for the state sequences associated to random systems with complete connections.     

On Markov chains induced by partitioned transition probability matrices

Let S be a denumerable state space and let P be a transition probability matrix on S. If a denumerable set M of nonnegative matrices is such that the sum of the matrices is equal to P, then we call M a partition of P.     

Gas chromatographic determination of 2- and 3-dechloroethylifosfamide in plasma and urine.

The metabolic oxidation of one of the chloroethyl groups of the antitumour drug ifosfamide leads to the formation of the inactive metabolites 2- and 3-dechloroethylifosfamide together with the neurotoxic metabolite chloroacetaldehyde. A very sensitive capillary gas chromatographic method, requiring only 50 microliters of plasma or urine, has been developed to measure the amounts of the drug and the two inactive metabolites in a single run. Calibration curves were linear (r > 0.999) in the concentration ranges from 50 ng/ml to 100 micrograms/ml in plasma and from 100 ng/ml to 1 mg/ml in urine.