Synthese De (1,2a)Benzimidazolo-1,3,5,2-triazaphosphorine-2-oxides

The reaction of hexamethylphosphotriamide or methylphosphonic bis(dimethylamide) compounds with amidines derived from N-Benzimidazoyl imidates 1 leads to (1,2a)benzimidazolo-1,3,5,2-tiazaphosphorine-2-oxides 4 in good yields. If the condensation is realized at room temperature, N-phosphonic amidines 3 can be isolated as intermediates. The isolated compounds 2 , 3 , and 4 are identified by spectroscopic methods: IR, 1 H, 13 C, 31 P, NMR, and M.S.     

Action of Organometallic Compounds on N-Cyanomethylimidate: New Synthetic Methode of Oxazole

The reaction of N-cyanomethylimidates with allylzinc bromide species has been examined. This reaction leads to the synthesis of oxazoles with good yields.     

Reaction of N-2-(1-Carbethoxy) - and N-2-(1-acyl)-benzimidazoimidates with Grignard Reagents. Synthesis of 1,3,5-Oxadiazino-(1,2-a)benzimidazoles

Reaction of ethyl chloroformate and acyl chlorides with iminoesters derived from 2- aminobenzimidazole, followed by Grignard reagent condensation leads to a variety of oxadiazinobenzimidazoles in good yield.     

REACTION DES O,O-DIETHYL OXO-1 ALKANEPHOSPHONATES AVEC LES DERIVES DE L'HYDRAZINE: UNE VOIE DE SYNTHESE DES HYDRAZONES α-PHOSPHONATEES ET DES HYDRAZIDES

Abstract

Under the normal conditions, the reaction of hydrazine and methylhydrazine with OO-diethyl 1 oxoalkane phosphonates 1 proceeds by cleavage of the phosphorus-carbon bond and leads to the formation of diethylphosphite 2 and N-acylhydrazide 3 . A procedure has been developed for the synthesis of new primary hydrazone of OO-diethyl 1-oxoalkane phosphonates 4 . A mechanism is proposed. The structure of those compounds 4 was confirmed by NMR and IR spectroscopy.     

Synthesis of -5,6 Dihydro-1,4,2 Dioxazines from Hydroximates

Successive action of α-bromoesters and organometallics on hydroximates constitute a good way to obtain - 5,6 dihydro-1,4,2 dioxazines.     

Surface plasmon resonance immunosensor for bacteria detection

This work describes an approach for the development of two bacteria biosensors based on surface plasmon resonance (SPR) technique. The first biosensor was based on functionalized gold substrate and the second one on immobilized gold nanoparticles. For the first biosensor, the gold substrate was functionalized with acid-thiol using the self-assembled monolayer technique, while the second one was functionalized with gold nanoparticles immobilized on modified gold substrate. A polyclonal anti-Escherichia coli antibody was immobilized for specific (E. coli) and non-specific (Lactobacillus) bacteria detection. Detection limit with a good reproducibility of 10⁴ and 10³ cfu mL⁻¹ of E. coli bacteria has been obtained for the first biosensor and for the second one respectively. A refractive index variation below 5 × 10⁻³ due to bacteria adsorption is able to be detected. The refractive index of the multilayer structure and of the E. coli bacteria layer was estimated with a modeling software.     

On the divisor function of sets with even partition functions

Summary For P∈ F₂[z] with P(0)=1 and deg(P)≧ 1, let A =A(P) be the unique subset of N (cf. [9]) such that Σ_n≧0 p(A,n)zⁿ ≡ P(z) mod 2, where p(A,n) is the number of partitions of n with parts in A. To determine the elements of the set A, it is important to consider the sequence σ(A,n) = Σ _{d|n, d∈A} d, namely, the periodicity of the sequences (σ(A,2^kn) mod 2^k+1)_n≧1 for all k ≧ 0 which was proved in [3]. In this paper, the values of such sequences will be given in terms of orbits. Moreover, a formula to σ(A,2^kn) mod 2^k+1 will be established, from which it will be shown that the weight σ(A₁,2^kz_i) mod 2^k+1 on the orbit <InlineEquation ID=IE"1"><EquationSource Format="TEX"><![CDATA[<InlineEquation ID=IE"2"><EquationSource Format="TEX"><![CDATA[$]]></EquationSource></InlineEquation>]]></EquationSource></InlineEquation>z_i$ is moved on some other orbit z_j when A₁ is replaced by A₂ with A₁= A(P₁) and A₂= A(P₂) P₁ and P₂ being irreducible in F₂[z] of the same odd order.     

Poly(N,N-dimethylacrylamide)-grafted polyacrylamide: a self-coating copolymer for sieving separation of native proteins by CE

The potential of a series of newly synthesized poly(N,N-dimethylacrylamide) (PDMA) grafted polyacrylamide (PAM) copolymers (P(AM-PDMA)) as a replaceable separation medium for protein analysis was studied. A comparative study with and without copolymers was performed; the separation efficiency, analysis reproducibility and protein recovery proved that the P(AM-PDMA) copolymers were efficient in suppressing the adsorption of basic proteins onto the silica capillary wall. Furthermore, the size-dependent retardation of native proteins in a representative P(AM-PDMA) copolymer was demonstrated by Ferguson analysis. The results showed that the P(AM-PDMA) copolymers combine the good coating property of PDMA and the sieving property of PAM and could be applied as a sieving matrix for the analysis of native proteins.