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本文应用逆行荧光物标记法和荧光组织化学的结合技术研究了大白鼠中缝大核(NRM)区的单胺能神经末梢的来源。结果证明,支配NRM的神经末梢来源于去甲肾上腺素(NA)能、5-羟色胺(5-HT)能和非单胺能三类神经元。NA能末梢主要起始于延脑网状外侧核(A1区)、下橄榄核背外侧区(A3区)、桥脑蓝斑核(A6区)的腹部、蓝斑下核(A7区)和中脑中缝背核(B7区)外侧区的NA能细胞。5-HT末梢主要发自于延脑中缝苍白核(B1区)、中缝暗核(B2区)、桥脑中缝核(B5-B6区)和中脑中缝核(B8-B9区)的少量5-HT细胞。非单胺能末梢主要来源于下橄榄核和脑干各个水平的网状结构,如延脑巨细胞网状核、桥脑网状尾核和中脑背被盖区腹外侧的神经细胞。对这些末梢可能的功能进行了讨论。 相似文献
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本文探讨了在针刺对内脏传入信号的抑制效应中,下行性抑制是否参与的问题。在麻痹的清醒猫的皮层眶回记录由刺激内脏神经引起的诱发电位,并用计算机叠加,这种诱发电位可被电针所抑制,切割脊髓下行抑制通路(位于背外侧索)后,后肢或前肢电针抑制眶回诱发电位的效应均大为减弱,由于前肢传入纤维在切割水平(第3—4胸段)以上进入脊髓,针刺信号至脊髓以上结构的神经通路可确保完整。损毁桥-延脑内侧网状结构中主要包含中缝大核的区域,电针抑制效应同样减弱,以上结果表示由针刺所激发的脊髓以上中枢(很可能是中缝大核)的下行冲动,在脊髓水平抑制了内脏传入信号的向上传递。 相似文献
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By the use of the fluorescent retrograde tracer, Fast Blue (FB), in combination with monoamine fluorescence histochemistry, the origin of monoaminergic input to the region of the nucleus raphe magnus (NRM) was investigated in the rat. After mieroinjection of FB into the NRM, a great number of FB-laboled NA-containing cells were found in the region of the nucleus reticularis lateralis (corresponding to A1 NA areas), the reticular formation just dorsolateral to the nucleus olivaris inferior (corresponding to the A3 NA area), the ventral part of the locus coeruleus (A6 NA area), and the lateral parts of the nucleus raphe dorsalis (B7 area). In the other NA cell groups of the brain stem, FB-labeled cells could not be observed. Serotoninergic input originating from nucleus raphe obscurus (B2), nucleus raphe pallidus (B1) and nucleus raphe pontis (BS-B6) to the NRM was also observed. A large number of cells containing serotonin (5-HT) in the B2 and B6 areas were labeled by FB, while only a few FB-labeled 5-HT 相似文献
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