Synthesis of Substituted Aminopyrimidines as Novel Promising Tyrosine Kinase Inhibitors

Russian Journal of Organic Chemistry - A procedure has been proposed for the synthesis of a series of substituted N-(1,3-thiazol-2-yl)-pyrimidin-2-amines and N-(pyrimidin-2-yl)thioureas by...     

Polymeric derivatives of dipterocarpol, a dammarane triterpenoid

Polymeric derivatives of dammarane triterpenoids with both labile and strong (covalent) polymer-triterpenoid bonds were prepared from N-vinylpyrrolidone copolymers.     

First radical cation salts of 2,5-bis(1,3-dithian-2-ylidene)-1,3,4,6-tetrathiapentalene (BDA-TTP) with copper(II) metal complex anions: β-(BDA-TTP)4Cu2Cl6 and (BDA-TTP)2CuCl4

New radical cation salts based on 2,5-bis(1,3-dithian-2-ylidene)-1,3,4,6-tetrathiapentalene (BDA-TTP) with copper(II) metal complex anions, β-(BDA-TTP)₄Cu₂Cl₆ and (BDA-TTP)₂CuCl₄, were synthesized and structurally characterized. Single crystals were prepared by electrochemical oxidation of BDA-TTP under galvanostatic conditions. X-ray diffraction study demonstrated that the salts have a layered structure, in which the conducting BDA-TTP layers alternate with the [Cu₂Cl₆]²⁻ or [CuCl₄]²⁻ anions. Both salts show the semiconductor-type temperature dependence of the conductivity. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 48–54, January, 2007.     

Linked crystallites in the conducting topmost layer of polymer bilayer films controlled by temperature: from micro- to nanocrystallites.

Temperature has great impact on the structure and size of the linked crystallites of the conducting topmost layer formed at the surface of a polycarbonate film via the reaction BEDT-TTF+IBr [BEDT-TTF=bis(ethylenedithio)tetrathiafulvalene]. We show that fine temperature control permits formation of a semiconducting topmost layer of alpha'-(BEDT-TTF)(2)(I(x)Br(1-x))(3) crystallites with either micro- or nanometre size, a result that opens a route to miniaturized conducting plastic materials.     

Photodynamic activity of chlorin e6 and chlorin e6 ethylenediamide in vitro and in vivo.

Several parameters of chlorin e6 and its derivative chlorin e6 ethylenediamide have been investigated as these compound are potential sensitizers for photodynamic therapy. A study carried out to compare the cellular uptake of the pigments indicates that chlorin e6 ethylenediamide possesses an enhanced affinity for tumour cells and cellular membranes. Comparison of the uptake in induced sarcoma shows that chlorin e6 ethylenediamide is a much better tumour localizer than chlorin e6. The efficiency of phototherapy with chlorin e6 ethylenediamide is higher than that with chlorin e6. These data show the influence of the substitution of the carboxyl groups in chlorin e6 by ester and amide groups on the photosensitizing properties of the pigments.     

Photochemical chlorination of 2-trichloromethyl-1,3-dioxolane

The photochemical chlorination of 2-trichloromethyl-1,3-dioxolane proceeds only at the carbon atoms in the 4 and 5 positions. The structures of the resulting 2-trichloromethyl-4-chloro-and 2-trichloromethyl-4,5-dichloro-1,3-dioxolanes were proved by means of the IR spectra and chemical transformations.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1611–1613, December, 1973.     

3‐Methylamido‐3′,4′‐ethyl­enedithiotetra­thia­fulvalene­(+) potassium tetra­isothio­cyanato­mercury(II)

In the title compound, (C₁₀H₉NOS₆)K[Hg(SCN)₄] or (EDT–TTF–CONHMe)K[Hg(SCN)₄)], fully oxidized organic (EDT–TTF–CONHMe)^+· radical cations form quasi‐one‐dimensional stacks running along the monoclinic 2₁ axis and alternating along the crystallographic [101] direction with inorganic anion stacks made from mixed K⁺–[Hg(SCN)₄]²⁻ ribbons. For each anion, three essentially collinear SCN ligands inter­act with the K⁺ ions via short N⋯K contacts, while the terminal N atom of the fourth SCN group is engaged in a number of hydrogen‐bond contacts with the –CH, –NH and –CH₂ hydrogen‐bond donors of the amide function. Radical cations are dimerized along the stacks and the crystal conductivity is activated.     

A method for measuring the shape of a surface of an ellipsoid of rotation on a Talysurf CCI 2000 interference microscope

A method for measuring the shape of the surface of an ellipsoid of rotation on a Talysurf CCI 2000 white-light scanning interference microscope is presented. The measurement results are compared to alternative measurements. It is shown that the measurement results are quite consistent.