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Hadisi Maliheh Vosoughi Naser Yousefnia Hassan Bahrami-Samani Ali Zolghadri Samaneh Vosoughi Sara Alirezapour Behrouz 《Journal of Radioanalytical and Nuclear Chemistry》2022,331(2):841-849
Journal of Radioanalytical and Nuclear Chemistry - In this study, optimized preparation, quality control, cell assessments and biostribution of 188Re-HYNIC-PSMA in normal rats and tumor bearing... 相似文献
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Tanoori Betsabeh Zolghadri Jahromi Mansoor Mansoori Eghbal G. 《Journal of computer-aided molecular design》2021,35(8):883-900
Journal of Computer-Aided Molecular Design - In the field of drug–target interactions prediction, the majority of approaches formulated the problem as a simple binary classification task.... 相似文献
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Arsam Golabi-dezfoli Hassan Yousefnia Mohammad Hosntalab Samaneh Zolghadri 《Journal of Radioanalytical and Nuclear Chemistry》2017,312(2):329-335
Nowadays, peptide receptor radionuclide therapy is used to treat a specific type of cancer called neuroendocrine tumors. In this research, the optimized conditions for 166Ho-DOTATOC production are presented. The radiolabeled compound was prepared with the specific activity of 11.1 TBq/mmol and radiochemical purity of more than 99% (using ITLC and HPLC). Stability tests of the complex were investigated in room temperature and in human serum at 37 °C. Biodistribution studies in Syrian rats showed considerable accumulation in pancreas as the somatostatin receptor-positive tissue. 166Ho-DOTATOC can be considered as a novel agent for treatment of somatostatin receptor-positive tumors. 相似文献
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In the present work, dispersive liquid-liquid microextraction based on solidification of floating organic drop was developed as a simple and rapid technique for separation of silver ions from aqueous samples. In this technique, 700 μL 0.02% of 5-(4'-dimethylamino benzyliden)-rhodanine (chelating agent) was added into the 10 mL analyte sample in a test tube and 30.0 μL 1-undecanol (extraction solvent) was injected shortly thereafter. The test tubes were sonicated, centrifuged and then some effective parameters on extraction and complex formation, such as type and volume of extraction and disperser solvent, pH, the amount of chelating agent and extraction time were optimized. The effect of the interfering ions on the analytes recovery was also investigated. The calibration graph was linear in the range of 0.10-10.0 ng mL(-1) with detection limit of 0.056 ng mL(-1) (n=8). The relative standard deviation (RSD) was ±4.3% (n=8, C=5.0 ng mL(-1)) and the enrichment factor was 250.0. The proposed method was applied for extraction and determination of silver in different water samples. 相似文献
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A novel synthesis of 1,2,4-oxadiazoles is described from a one-pot, three-component reaction between nitriles, hydroxylamine, and aldehydes under microwave irradiation and solvent-free conditions in excellent yields. 相似文献
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Fatemeh Habashi Abdolmohammad Mehranpour Enayatollah Bahman Jahromi 《Journal of heterocyclic chemistry》2020,57(6):2428-2432
The preparation of several bis(1,4-diazepinium) salts from the reaction of three 1,2-diamines with a bis(vinamidinium) salt is described. Bis(γ-substituted pentamethine cyanine(dyes are also prepared from the reaction of vinamidinium salt with 1,2-dimethylquinolinium perchlorate and 1,2,3,3-tetramethyl-3H-indolium perchlorate. Data from elemental analyzes, IR, 1H-NMR, 13C-NMR, and mass spectra (MS) confirm the molecular structure of the obtained products. 相似文献
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Zohreh Mehri Lighvan Hossein Ali Khonakdar Abolfazl Heydari Mina Rafiee Maryam Dehdashti Jahromi Ali Derakhshani Amir Abbas Momtazi-Borojeni 《应用有机金属化学》2020,34(10):e5839
The organometallic palladium complex with nitrogen-containing heterocycles is a potent antitumor agent. Coordination of phosphorus ligands to organometallic complexes increases their hydrophilicity, promotes ligand−DNA interactions and damage level to cancer cells, and blocks division in target cells. In this study, a phosphaadamantane palladium complex ([Pd{(C,N)- (C12H8NH2)} (PTA) Cl], PTA = 1,3,5-Triaza-7-phosphaadamantane) ( 2 ) was synthesized via the reaction of biologically active PTA with binuclear palladacycles [Pd2{(C,N)-(C12H8NH2)}2(μ-Cl)2] ( 1 ). In vitro studies of the complex with DNA (calf-thymus) explored by UV–Vis, emission titration, circular dichroism and helix melting methods showed that the complex interacts with DNA via an intercalative mechanism. Furthermore, competitive binding studies using warfarin, digoxin and ibuprofen site markers containing definite binding sites revealed the binding of the complex to site I on bovine serum albumin. The in vitro release mechanism of the palladium complex exhibited a biphasic pattern characterized by an initial burst release followed by a slower sustained release. Ultimately, in vitro evaluation of cytotoxicity and cell death showed that the complexes were able to decrease the viability of human cancer cell lines (MCF-7 and Jurkat) in a dose-dependent manner, but lower decreases were observed in the viability of normal fibroblast cells ASF-4 at the dosages evaluated. Finally, the order of in vitro anticancer activities was found to be consistent with the DNA-binding affinities. 相似文献