Backward particle production in neutrino neon interactions

Backward proton and pion production is studied in ν and \(\bar v\) charged current interactions in neon. The results are compared with other experiments and theory. The complete backward proton data is compatible with protons produced by reinteractions in the nucleus. However in events with only one proton, muon variables appear correlated to those for the backward proton, as expected by the two-nucleon correlation model.     

Coherent single pion production by antineutrino charged current interactions and test of PCAC

The cross section for coherent production of a single π^? meson in charged current antineutrino interactions on neon nuclei has been measured in BEBC to be (175±25) 10^?40 cm²/neon nucleus, averaged over the energy spectrum of the antineutrino wide band beam at the CERN SPS; this corresponds to (0.9±0.1) % of the total charged current \(\bar v_\mu \) cross section. The distributions of kinematical variables are in agreement with theoretical predictions based on the PCAC hypothesis and the meson dominance model; in particular, theQ ² dependence is well described by a propagator containing a massm=(1.35±0.18) GeV. The absolute value of the cross section is also in agreement with the model. This analysis thus provides a test of the PCAC hypothesis in the antineutrino energy range 5–150 GeV.     

Phase-field modeling of void evolution and swelling in materials under irradiation

Void swelling is an important phenomenon observed in both nuclear fuels and cladding materials in operating nuclear reactors. In this work we develop a phase-field model to simulate void evolution and void volume change in irradiated materials. Important material processes, including the generation of defects such as vacancies and self-interstitials, their diffusion and annihilation, and void nucleation and evolution, have been taken into account in this model. The thermodynamic and kinetic properties, such...     

First Synthesis of Thienopyrazole Thioglycosides

Reported is the first method to prepare a new class of thienopyrazole thioglycosides via a one‐pot reaction of the sodium thienopyrazolthiolate salts with 2,3,4,6‐tetra‐O‐acetyl‐α‐D‐gluco‐and galactopyranosyl bromides. The sodium thienopyrazolthiolate salts are prepared using pyrazoldithioic acids and their corresponding mono ‐ and dithiolate salts.     

Discovery of New Coumarin-Based Lead with Potential Anticancer,CDK4 Inhibition and Selective Radiotheranostic Effect: Synthesis, 2D & 3D QSAR,Molecular Dynamics,In Vitro Cytotoxicity,Radioiodination, and Biodistribution Studies

Novel 6-bromo-coumarin-ethylidene-hydrazonyl-thiazolyl and 6-bromo-coumarin-thiazolyl-based derivatives were synthesized. A quantitative structure activity relationship (QSAR) model with high predictive power r² = 0.92, and RMSE = 0.44 predicted five compounds; 2b, 3b, 5a, 9a and 9i to have potential anticancer activities. Compound 2b achieved the best ΔG of –15.34 kcal/mol with an affinity of 40.05 pki. In a molecular dynamic study 2b showed an equilibrium at 0.8 Å after 3.5 ns, while flavopiridol did so at 0.5 Å after the same time (3.5 ns). 2b showed an IC₅₀ of 0.0136 µM, 0.015 µM, and 0.054 µM against MCF-7, A-549, and CHO-K1 cell lines, respectively. The CDK4 enzyme assay revealed the significant CDK4 inhibitory activity of compound 2b with IC₅₀ of 0.036 µM. The selectivity of the newly discovered lead compound 2b toward localization in tumor cells was confirmed by a radioiodination biological assay that was done via electrophilic substitution reaction utilizing the oxidative effect of chloramine-t. ¹³¹I-2b showed good in vitro stability up to 4 h. In solid tumor bearing mice, the values of tumor uptake reached a height of 5.97 ± 0.82%ID/g at 60 min p.i. ¹³¹I-2b can be considered as a selective radiotheranostic agent for solid tumors with promising anticancer activity.     

Synthesis, characterization and evaluation of99mTc-L, L-ethylenecysteine dimer to assess regional cerebral blood flow

L,L-ethylenecysteine dimer (L,L-ECD) compound was synthesized with an overall yield 31.2% and a melting point 197–198°C. A systematic study has been carried out on the labelling of L,L-ECD with technetium-99m by ligand exchange via^99mTc-EDTA. The percent labelling yield of L,L-ECD was found ≥95% when 0.75 2.0 mg and 100 μg of L,L-ECD, disodium-EDTA and tin (II) were used, respectively, at pH 5.5. The produced^99mTc-L,L-ECD complex is stable, neutral and lipid soluble. The^99mTc-L,L-ECD complex penetrate the blood-brain barrier following intravenous injection in the tail vein of mice with an initial brain uptake equal to 0.9% at 2 minutes and a slow washout equal to 0.65% after 25 minutes. High uptake in the gastrointestinal tract (GIT) was observed. It reaches up to 38.9% at 2 minutes and increased as time pass reaching 48.3% at 60 minutes. These results indicate that this ligand is suitable for brain imaging and has a tendency to be excreted via liver and GIT due to its lipophilicity.     

A search for the exotic Ξ<Superscript>−−</Superscript> (1860) in the hyperon beam experiment WA89(1860) in the hyperon beam experiment WA89

We report on a high statistics search for the Ξ^??(1860) resonance in Σ^?-nucleus collisions at 340 GeV/c. No evidence for this resonance is found in our data sample which contains 676000 Ξ^? candidates above bakground. For the decay channel Ξ^??(1860)→Ξ^? π ^? and the kinematic range 0.15<xF<0.9 we find a 3σ upper limit for the production cross section of 3.1 and 3.5 μb per nucleon, for reactions with carbon and copper, respectively.     

Double prompt photon production at high transverse momentum byπ − on protons at 280 GeV/c

A search for pairs of highp _T prompt photons produced in hydrogen by a 280 GeV/c incidentπ ^- beam has been carried out using a fine-grained electromagnetic calorimeter and the Omega spectrometer at the CERN SPS. Clear evidence for the existence of such events is found with a six standard deviation signal forp _T >3.0 GeV/c. The cross-sections are consistent with beyond leading order QCD calculations. A discussion on the determination of α _s is also presented.