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[reaction: see text]. A novel synthetic methodology for 2,5-disubstituted tetrahydrofurans having an allenyl group at the 3-position via Prins-type cyclization was developed. The reaction led to excellent selectivity and moderate to high yields. 相似文献
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[reaction: see text] Intramolecular Prins-type reactions of compounds having both functionalities of homoallyl alcohol and acetal moiety are described. The intramolecular Prins cyclizations were performed using indium trichloride in chloroform or 25% aqueous THF. Both 9-oxabicyclo[3.3.1]nonane and 3,9-dioxabicyclo[3.3.1]nonane compounds were successfully obtained in moderate yields. 相似文献
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Cho YS Karupaiyan K Kang HJ Pae AN Cha JH Koh HY Chang MH 《Chemical communications (Cambridge, England)》2003,(18):2346-2347
Synthesis of novel substituted tetrahydropyrans with adjacent exo-methylene groups at the C3 and C4 positions via Prins-type cyclization has been described. 相似文献
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The effects of combined pressure and temperature on the mechanical behavior of polypropylene have been studied. Tests were conducted in tension and compression superimposed on various hydrostatic pressures up to 7 kbar at temperatures of 20, 50, and 75°C. The experimental data have been analyzed in view of molecular and continuum approaches. It has been observed that the Young's modulus and the yield strength in both tension and compression increased significantly with increasing pressure at all temperatures studied. However, the rate of increase of the Young's modulus undergoes abrupt change about the glass-transition pressure (Pg). The Pg is linearly dependent on the test temperature and the pressure coefficient of the Tg is estimated, from Pg versus temperature relations, to be about 18°C/kbar for the polypropylene samples of this study. Pressure dependence of the yield stress is described by a generalized Eyring theory incorporating pressure effects and two flow mechanisms, the α- and the β-relaxation processes. The theory predicts a bilinear dependence of the yield stress of polypropylene on hydrostatic pressure as observed in the tests. The paper also described a method of healing stress whitening in polypropylene by a combination of shear stress and hydrostatic pressure. 相似文献
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Kim HJ Doddareddy MR Choo H Cho YS No KT Park WK Pae AN 《Journal of chemical information and modeling》2008,48(1):197-206
Serotonin 5-HT6 receptor antagonists are thought to play an important role in the treatment of psychiatry, Alzheimer's disease, and probably obesity. To find novel and potent 5-HT6 antagonists and to provide a new idea for drug design, we used a ligand-based pharmacophore to perform the virtual screening of a commercially available database. A three-dimensional common feature pharmacophore model was developed by using the HipHop program provided in Catalyst software and was used as a query for screening the database. A recursive partitioning (RP) model which can separate active and inactive compounds was used as a filtering system. Finally a sequential virtual screening procedure (SQSP) was conducted, wherein both the common feature pharmacophore and the RP model were used in succession to improve the results. Some of the hits were selected based on druglikeness, ADME properties, structural diversity, and synthetic accessibility for real biological evaluation. The best hit compound showed a significant IC50 value of 9.6 nM and can be used as a lead for further drug development. 相似文献
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Exocyclic products having cis-2,5 and cis-2,6 substitution were synthesized from terminally substituted alkynyl alcohols with various aldehydes via Prins-type cyclization in good yields. It is of interest that synthesized 5- and 6-exocyclic vinyl cations generated as a result of Prins-type cyclization could be trapped as a vinyl triflate in CH2Cl2 to give 3-furanylidenes and 3-pyranylidenes. Those 3-furanylidenes and 3-pyranylidenes underwent hydrolysis to give the corresponding 3-acyl-substituted products having all-cis-configured isomers, such as 2,3,5-trisubstituted tetrahydrofurans and 2,3,6-trisubstituted tetrahydropyrans. 相似文献
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Youlee Pae Frank W. Harris 《Journal of polymer science. Part A, Polymer chemistry》2000,38(23):4247-4257
Nylon‐6‐b‐polyimide‐b‐nylon‐6 copolymers were prepared by first synthesizing a series of imide oligomers end‐capped with phenyl 4‐aminobenzoate. The oligomers were then used to activate the anionic polymerization of molten ϵ‐caprolactam. In the block copolymer syntheses, the phenyl ester groups reacted quickly with caprolactam anions at 120 °C to generate N‐acyllactam moieties, which activated the anionic polymerization. In essence, nylon‐6 chains grew from the oligomer chain ends. All of the block copolymers had higher moduli and tensile strengths than those of nylon‐6. However, their elongations at break were much lower. The thermal stability, chemical resistance, moisture resistance, and impact strength were dramatically increased by the incorporation of only 5 wt % polyimide in the block copolymers. © 2000 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 38: 4247–4257, 2000 相似文献
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