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Yamien Effi Jean-Charles Lancelot Sylvain Rault Max Robba 《Journal of heterocyclic chemistry》1986,23(1):17-23
The reactivity of pyrrolo[1,2-a]thieno[2,3-e]pyrazine towards quaternisation, bromination, nitration, Friedel-Crafts, Vilsmeier-Haack and Reissert reactions was studied. Assignment of structures to the product is based upon ir, nmr and mass spectral studies. 相似文献
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Acceleration of Long‐Range Photoinduced Electron Transfer through DNA by Hydroxyquinolines as Artificial Base Pairs 下载免费PDF全文
Dr. Effi Bätzner Dr. Yu Liang Caroline Schweigert Dr. Andreas‐Neil Unterreiner Prof. Dr. Hans‐Achim Wagenknecht 《Chemphyschem》2015,16(8):1607-1612
The C‐nucleoside based on the hydroxyquinoline ligand (Hq) is complementary to itself and forms stable Hq–Hq pairs in double‐stranded DNA. These artificial Hq–Hq pairs may serve as artificial electron carriers for long‐range photoinduced electron transfer in DNA, as elucidated by a combination of gel electrophoretic analysis of irradiated samples and time‐resolved transient absorption spectroscopy. For this study, the Hq–Hq pair was combined with a DNA‐based donor–acceptor system consisting of 6‐N,N‐dimethylaminopyrene conjugated to 2′‐deoxyuridine as photoinducible electron donor, and methyl viologen attached to the 2′‐position of uridine as electron acceptor. The Hq radical anion was identified in the time‐resolved measurements and strand cleavage products support its role as an intermediate charge carrier. Hence, the Hq–Hq pair significantly enhances the electron hopping capability of DNA compared to natural DNA bases over long distances while keeping the self‐assembly properties as the most attractive feature of DNA as a supramolecular architecture. 相似文献
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Sylvain Rault Yamien Effi Michel Cugnon De Sevricourt Jean-Charles Lancelot Max Robba 《Journal of heterocyclic chemistry》1983,20(1):17-21
The synthesis of pyrrolo[1,2-α]thieno[3,2-e]pyrazine and pyrrolo[1,2-α]-thieno[2,3-e]pyrazine is described. These syntheses could be achieved by intramolecular cyclization of 2- (and 3-) (1-pyrrolyl)-3- (and -2)-thienyl-amines obtained by hydrolysis of carbamates or by cleavage of the corresponding ureas. An original way giving better results was also studied via a Curtius rearrangement by reaction between the azide and aldehyde groupings. The synthesis of 2- (and -3)-2-formyl-1-pyrrolyl)-2- (and -3)-thenoylazide is described. 相似文献
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The structure of the monoclinic modification of 1,6-trans-diaminocyclodecanedihydrochloride has been determined, and refined by full-matrix least-squares analysis of three-dimensional X-ray data. The cyclodecane skeleton is very similar to that found previously in the triclinic modification, but the substituents are attached to different types of carbon atoms. The two crystal modifications thus correspond to different conformational isomers. 相似文献
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Yamien Effi Sylvain Rault Jean-Charles Lancelot Max Robba 《Journal of heterocyclic chemistry》1987,24(2):431-435
5-Aminopyrrolo[1,2-a]thieno[2-3-3]pyrazine derivatives were obtained by intramolecular cyclisation of N3(1-pyrrolyl)-2-thienylurea derivaties. Synthesis of these latter compounds was achieved from 2-(1-pyrrolyl)-3-thenoylazide via a curtius rearrangement. The H nmr spectra are discussed. 相似文献
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Stürzl M Konrad A Sander G Wies E Neipel F Naschberger E Reipschläger S Gonin-Laurent N Horch RE Kneser U Hohenberger W Erfle H Thurau M 《Combinatorial chemistry & high throughput screening》2008,11(2):159-172
Reversely transfected cell microarrays (RTCM) have been introduced as a method for parallel high throughput analysis of gene functions in mammalian cells. Hundreds to thousands of different recombinant DNA or RNA molecules can be transfected into different cell clusters at the same time on a single glass slide with this method. This allows either the simultaneous overexpression or--by using the recently developed RNA interference (RNAi) techniques--knockdown of a huge number of target genes. A growing number of sophisticated detection systems have been established to determine quantitatively the effects of the transfected molecules on the cell phenotype. Several different cell types have been successfully used for this procedure. This review summarizes the presently available knowledge on this technique and provides a laboratory protocol. 相似文献
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Yamien Effi Jean-Charles Lancelot Sylvain Rault Max Robba 《Journal of heterocyclic chemistry》1983,20(4):913-918
The 4,5-dihydropyrrolo[1,2-e]pyrazin-5-one (1) exhibits lactam-lactim tautomerism. N-Electrophilic substitutions could be achieved via the intermediate of the substitutions could be achieved via the intermediate of the sodium salt la. The 5-chloropyrazine 11 obtained by chlorodehydroxylation of pyrazinone 1 allowed nucleophilic substitution. Thionation of the pyrazinone 1 afforded the thioxopyrazine 27 wich gave studied and the tautomerism of the hydrazinopyrazine 14 and its derivatives are discussed in terms of hydrazone and azine structures 相似文献
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