排序方式: 共有4条查询结果,搜索用时 15 毫秒
1
1.
Luba Ignatovich Olga Starkova Vitalijs Romanovs Ilze Sleiksha Irina Shestakova Jury Popelis Edmunds Lukevics 《Comptes Rendus Chimie》2013,16(6):621-627
The reaction of 1,2-phenylenediamine with a variety of silicon- or germanium-containing 2-furaldehydes or 2-thienylcarbaldehydes in DMFA gave the corresponding benzimidazole derivatives in moderate yields (36–49%) in the presence of sodium hydrogen sulfite. As a result, a new series of silyl, germyl substituted hetarylbenzimidazoles were synthesized and their in vitro cytotoxicity was studied. The quaternisation of N-substituted benzimidazoles by heating with various alkyl, allyl and propargyl chlorides and bromides leads to the formation of benzimidazolinium salts. Potential cytotoxic activity of synthesized new benzimidazoles and benzimidazolinium salts was tested in vitro on two monolayer tumour cell lines: MG-22A (mouse hepatoma), HT-1080 (human fibrosarcoma) and normal mouse fibroblasts (NIH 3T3) and compared with corresponding benzimidazoles. 相似文献
2.
Synthesis and Cytotoxic Activity of 1‐{3‐[1‐(5‐Organylsilylfuran‐2‐yl)silinan‐1‐yl]propyl}amines and Some Trimethylgermyl Analogues 下载免费PDF全文
Dr. Luba Ignatovich Dr. Vitalijs Romanovs Velta Muravenko Ilze Sleiksha Dr. Jury Popelis Dr. Irina Shestakova 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(40):12786-12788
New highly cytotoxic 1‐{3‐[1‐(5‐organylsilyl‐furan‐2‐yl)silinan‐1‐yl]propyl}amines and some trimethylgermyl analogues (IC50 1–7 μg mL?1) have been synthesized by a hydrosilylation reaction of aliphatic and heterocyclic N‐allylamines in the presence of Speier’s catalyst. The effects of the silacycle, the element‐organic substituent in position 5 of the furan ring, and the structure of the amine on the cytotoxicity of the new compounds have been studied. 相似文献
3.
L. Ignatovich V. Romanovs I. Shestakova I. Domrachova J. Popelis E. Lukevics 《Chemistry of Heterocyclic Compounds》2009,45(12):1441-1448
New highly cytotoxic 3-aminopropyl derivatives of 2-dimethylsilyl-5-trialkylgermylfuran (IC50 1−3 μg⋅ml−1) have been prepared by hydrosilylation of heterocyclic N-allylamines with the corresponding hydrosilane in the presence of
Speier’s catalyst. The influence of the amine structure and alkyl substituent at the germanium atom on the cytotoxicity has
been investigated. 相似文献
4.
1