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Conventional chemotherapy remains an integral part of lung cancer therapy, regardless of its toxicity and drug resistance. Consequently, the discovery of an alternative to conventional chemotherapy is critical. Artemisia santolinifolia ethanol extract (AS) was assessed for its chemosensitizer ability when combined with the conventional anticancer drug, docetaxel (DTX), against non-small cell lung cancer (NSCLC). SRB assay was used to determine cell viability for A549 and H23 cell lines. The potential for this combination was examined by the combination index (CI). Further cell death, analyses with Annexin V/7AAD double staining, and corresponding protein expressions were analyzed. Surprisingly, AS synergistically enhanced the cytotoxic effect of DTX by inducing apoptosis in H23 cells through the caspase-dependent pathway, whereas selectively increased necrotic cell population in A549 cells, following the decline in GPX4 level and reactive oxygen species (ROS) activation with the highest rate in the combination treatment group. Furthermore, our results highlight the chemosensitization ability of AS when combined with DTX. It was closely associated with synergistic inhibition of oncogenesis signaling molecule STAT3 in both cell lines and concurrently downregulating prosurvival protein Survivin. Conclusively, AS could enhance DTX-induced cancer cells apoptosis by abrogating substantial prosurvival proteins’ expressions and triggering two distinct cell death pathways. Our data also highlight that AS might serve as an adjunctive therapeutic option along with a conventional chemotherapeutic agent in the management of NSCLC patients. 相似文献
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Cellulose - The toxicity level of conventional hydrogels is considerably high for most applications. To date, very few studies on hydrogels synthesized using only safe materials and simple,... 相似文献
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E. Nyamdavaa E. Uyanga G. Sevjidsuren P. Altantsog 《Journal of Surface Investigation: X-ray, Synchrotron and Neutron Techniques》2017,11(2):366-370
Cerium doped lanthanum cobaltite perovskites La1–x Ce x CoO3 with x = 0, 0.2, 0.4 were prepared by the sol-gel method (calcined for 5 h at 750°C) and characterized by X-ray diffraction, X-ray absorption, energy dispersive X-ray spectroscopy and Brunauer–Emmett–Teller surface area analysis. The results showed that the cerium doping promoted the structural transformation of LaCoO3 from rhombohedral into cubic structure. High specific surface area and small crystallite size were achieved at x = 0.2. The X-ray absorption results confirmed the formation of compound La1–x Ce x CoO3. 相似文献
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