Synthesis and Antiviral Evaluation of (1,4-Disubstituted-1,2,3-Triazol)-(E)-2-Methyl-but-2-Enyl Nucleoside Phosphonate Prodrugs

A series of hitherto unknown (1,4-disubstituted-1,2,3-triazol)-(E)-2-methyl-but-2-enyl nucleosides phosphonate prodrugs bearing 4-substituted-1,2,3-triazoles were prepared in a straight approach through an olefin acyclic cross metathesis as the key synthetic step. All novel compounds were evaluated for their antiviral activities against HBV, HIV and SARS-CoV-2. Among these molecules, only compound 15j, a hexadecyloxypropyl (HDP)/(isopropyloxycarbonyl-oxymethyl)-ester (POC) prodrug, showed activity against HBV in Huh7 cell cultures with 62% inhibition at 10 μM, without significant cytotoxicity (IC₅₀ = 66.4 μM in HepG2 cells, IC₅₀ = 43.1 μM in HepG2 cells) at 10 μM.     

超强激光等离子体相互作用中的自生磁场与能量运输

采用数值方法研究了超强激光与等离子体相互作用中产生的电磁不稳定性及其产生机制。用Spitzer-Harm理论分析了电子热传导中能量的运输情况,观察到由激光的非等方加热引起的电子纵向加热现象。结果表明,不稳定性激发的强电磁场使电子束在非常短的距离内沉积能量,同时对在激光有质动力推开电子时形成的电子热流产生抑制作用。同时发现,随着自生磁场的增长,电子被磁场波捕捉,热运输受抑制。     

激光等离子体相互作用中Weibel不稳定性

利用粒子模拟法对超强激光与等离子体相互作用中产生的Weibel不稳定性及其产生机制进行了详细的研究。给出不稳定性的线性色散关系和饱和磁场与各向异性参数之间的函数关系,发现Weibel不稳定性的存在使超强激光在等离子体中激发的自生磁场饱和,饱和自生磁场的存在使粒子速度分布在激光传播方向上表现出各向异性。讨论了Weibel不稳定性的线性和非线性饱和过程,对更好地理解快点火物理中自生磁场的产生、快电子输运等过程有重要意义。