Synthesis of alkaloid-like compounds via the bridging Ritter reaction

Abstract  

Alkaloid-like compounds containing a benzo[c]azepine core structure were successfully prepared in three steps from 5H-dibenzo[a,d]cyclohepten-5-ol via the bridging Ritter reaction. Biological studies of these compounds revealed that some of them are AChE inhibitors and antimalarial agents.     

A Rare Alder-ene Cycloisomerization of 1,6-Allenynes

Thermally induced cycloisomerization reactions of 1,6-allenynes gives α-methylene-γ-lactams via intramolecular Alder-ene reactions. The mechanism is supported by computational and deuterium labelling studies. This thermal, non-radical method enables the discovery of a hitherto unknown route that proceeds via a divergent mechanism distinct from the previous [2+2] cycloisomerization manifold.     

Comparison of different Vetiver grass pretreatment techniques and their impact on immobilized butanol production by Clostridium beijerinckii TISTR 1461

Cellulose - Immobilization of microbe cells has been considered as a potential alternative for enhancing biobutanol productivity through acetone-butanol-ethanol (ABE) fermentation. Vetiver grass...