WAVELENGTH DEPENDENCE OF SINGLET OXYGEN MECHANISM IN ACRIDINE ORANGE-SENSITIZED PHOTODYNAMIC ACTION IN YEAST CELLS: EXPERIMENTS WITH 470 NM

Abstract— The singlet oxygen mechanism was evaluated in terms of acridine orange-sensitized induction of gene conversion in Saccharomyces at 470 nm and by using a concentration dependent protective action of added N;. The singlet oxygen mechanism accounted for 96% of the total photodynamic efTect. This value is to be contrasted with 76% previously observed for 510 nm illumination.     

The drug release profile from calcium-induced alginate gel beads coated with an alginate hydrolysate

Calcium-induced alginate gel bead (Alg-Ca) coated with an alginate hydrolysate (Alg), e.g. the guluronic acid block (GB) was prepared and the model drug, hydrocortisone release profiles were investigated under simulated gastrointestinal conditions. Their molecular weights were one sixth or one tenth that of Alg and the diffraction patterns of the hydrolysates resembled that of Alg. The drug release rate from Alg-Ca coated with GB apparently lowered than that of Alg-Ca (coating-free) in the gastric juice (pH1.2). And the coating did not resist the disintegration of Alg-Ca in the intestinal juice (pH 6.8) and the gel erosion accelerated the drug release. On the other hand, for the coated Alg-Ca containing chitosan, the drug release showed zero-order kinetics without rapid erosion of Alg-Ca. The drug release rate from Alg-Ca was able to be controlled by the coating and modifying the composition of the gel matrix.     

Polyvinyl alcohol-acid redox active gel electrolytes for electrical double-layer capacitor devices

Journal of Solid State Electrochemistry - Since the mechanism of charge storage in electrical double-layer capacitors (EDLCs) relies on diffusion of ions into the pores of the electrodes, in...