排序方式: 共有18条查询结果,搜索用时 15 毫秒
1.
Jagadeesh B Prabhakar A Sarma GD Chandrasekhar S Chandrashekar G Reddy MS Jagannadh B 《Chemical communications (Cambridge, England)》2007,(4):371-373
Residue based control of specific helical folding is explored in hybrid peptide oligomers consisting of alternating L-Ala and cis-beta-furanoid sugar amino acid (FSAA) residues as building blocks; two series of these hybrid oligomers are designed, synthesized and extensively characterized by using NMR, CD, FT-IR and MD simulation studies; results show the co-existence of left-handed 11- and 14/15-helical conformations in these short oligomers of Boc-(alpha/beta) and Boc-(beta/alpha) series. 相似文献
2.
Murthy GS Johnston DB Rausch KD Tumbleson ME Singh V 《Applied biochemistry and biotechnology》2012,166(1):87-111
Ethanol from corn is produced using dry grind corn process in which simultaneous saccharification and fermentation (SSF) is
one of the most critical unit operations. In this work an optimal controller based on a previously validated SSF model was
developed by formulating the SSF process as a Bolza problem and using gradient descent methods. Validation experiments were
performed to evaluate the performance of optimal controller under different process disturbances that are likely to occur
in practice. Use of optimal control algorithm for the SSF process resulted in lower peak glucose concentration, similar ethanol
yields (13.38±0.36% v/v and 13.50±0.15% v/v for optimally controlled and baseline experiments, respectively). Optimal controller
improved final ethanol concentrations as compared to process without optimal controller under conditions of temperature (13.35±1.28
and 12.52±1.19% v/v for optimal and no optimal control, respectively) and pH disturbances (12.65±0.74 and 11.86±0.49% v/v
for optimal and no optimal control, respectively). Cost savings due to lower enzyme usage and reduced cooling requirement
were estimated to be up to $1 million for a 151 million L/yr (40 million gal/yr) dry grind plant. 相似文献
3.
Time consuming portions in the computation of transport properties of rigid and flexible molecules are the evaluation of subunit hydrodynamic interaction tensors Q and σ, and the procedure for satisfying subunit-subunit distance constraints. Vector algorithms to speed up these parts of the computation are given. Using these algorithms, a vector version of the Ermak-McCammon Brownian dynamics code has been developed on a Cyber-205. To demonstrate the order of speedups that can be achieved, the code was tested on a rigid “trimer” system comprising 24 spherical subunits with a fixed geometry. A speedup of about 14 times for the whole program, and of 45, 6, and 18 times for the computation of Q , σ, and for the procedure to enforce the constraints, respectively, were obtained. 相似文献
4.
In the past we have reported significant cognitive deficits in mice receiving 5‐fluorouracil in combination with low‐dose methotrexate. To explain such interactions, a pharmacokinetic study was designed. A sensitive bio‐analytical method was therefore developed and validated for 5‐fluorouracil and methotrexate in mouse plasma, brain and urine with liquid chromatography coupled to a single quadrupole mass spectrometer. Chromatographic separation was accomplished by Agilent® Zorbax® SB‐C18 column, with isocratic elution (5 mM ammonium acetate and methanol, 70:30, %v/v) at a flow rate of 300 μL/min. The limit of quantitation for both drugs was 15.6 ng/mL (plasma and brain) and 78.1 ng/mL (urine), with interday and intraday precision and accuracy ≤15% and a total run time of 6 min. This bio‐analytical method was used for the pharmacokinetic characterization of 5‐fluorouracil and methotrexate in mouse plasma, brain and urine over a period of 24 h. This method allowed characterization of the brain concentrations of 5‐fluorouracil over a period of 24 h. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
5.
Chandrasekhar S Rao CL Reddy MS Sharma GD Kiran MU Naresh P Chaitanya GK Bhanuprakash K Jagadeesh B 《The Journal of organic chemistry》2008,73(23):9443-9446
Short homo-oligomers of a new building block, cis-beta(2,3)-furanoid sugar aminoxy acid, are designed, characterized, and found to exhibit rigid ribbon-like secondary structures composed of 5/7 bifurcated intramolecular hydrogen bonds. 相似文献
6.
7.
M. M. Aggarwal S. K. Badyal V. S. Bhatia S. Chattopadhyay A. K. Dubey M. R. Dutta Majumdar M. S. Ganti A. Kumar T. K. Nayak S. Mahajan D. P. Mahapatra L. K. Mangotra B. Mohanty S. Pal S. C. Phatak B. V. K. Potukuchi R. Raniwala S. Raniwala N. KRao R. N. Singaraju Bikash Sinha M. D. Trivedi R. J. Veenhof Y. P. Viyogi 《Pramana》2003,60(5):1023-1027
A novel gas-based detector using large arrays of honeycomb cells has been developed and tested for use as a pre-shower photon
multiplicity detector (PMD) for STAR and ALICE experiments. The appropriate cell design was arrived at using GARFIELD simulations.
Prototype chambers with cell dimensions corresponding to STAR and ALICE were fabricated and tested at CERN PS and SPS. The
charged particle detection efficiency and the pre-shower characteristics have been studied using pion and electron beams. 相似文献
8.
Muonium spin rotation experiments have been performed in a system of benzene in liquid isopentane solutions in the temperature range between 136 K and 295 K. The observed chemical reaction rate constants show a concave curve in an Arrhenius plot. These results are interpreted in terms of to a significant quantum tunnelling effect for muonium reaction in solutions. The oscillating frequency and the width of barrier for such reactions were found to be 400 cm?1 and 2.1 Å respectively by curve-shape analysis. The reaction barrier (6.0 kJ/mol) is found to be less than the activation energy due to viscous flow of the solvent. 相似文献
9.
G. Anand Kumar H. S. Sahoo S. K. Satpathy G. Swarnabala 《Accreditation and quality assurance》2003,8(1):21-24
In an effort to assess the method validation done using ICP-AES in our laboratory for potable water, an Environmental Laboratory
Approval Program organized by New York State Department of Health, Wadsworth Center providing the reference material has been
undertaken for 14 trace elements and seven other chemical constituents. The certified means for the reference material and
the results obtained in our laboratory are compared. The comparisons helped us assess the quality of our work. All the data
from the inductively coupled plasma atomic emission spectrometer (ICP-AES) fall into the ranges specified. These data are
intended to depict the quality of chemical analysis being conducted in our laboratory and to increase the level of confidence
of our clientele in accepting our test reports. It should be further noted that while the technique may not be new, the model
is new and the simultaneous detection of elements required validation for those of our clientele who are only familiar with
sequential AAS and AES.
Received: 3 April 2002 Accepted: 4 September 2002 相似文献
10.
Sunkari Sailaja G. Swarnabala M. V. Rajasekharan 《Acta Crystallographica. Section C, Structural Chemistry》2001,57(10):1162-1165
Bis[(2-pyridylmethyl)ammonio]silver(I) trinitrate, [Ag(C6H9N2)2](NO3)3, (I), and bis{bis[(4-pyridylmethyl)ammonio]silver(I)} hexakis(perchlorate) dihydrate, [Ag(C6H9N2)2]2(ClO4)6·2H2O, (II), are rare examples of complexes with cationic ligands. In (I), the Ag+ cation has a T-shaped [2+1] coordination involving the pyridine N atoms and a nitrate O atom, while in (II) there are three independent two-coordinate Ag complex cations (two with the Ag atoms on independent inversion centres) and disordered ClO4− ions. The crystal structures reveal the role of hydrogen bonding in stabilizing these complexes. 相似文献